PMID- 26822260 OWN - NLM STAT- MEDLINE DCOM- 20161213 LR - 20181202 IS - 1872-8227 (Electronic) IS - 0168-8227 (Linking) VI - 115 DP - 2016 May TI - A high thyroid stimulating hormone level is associated with diabetic peripheral neuropathy in type 2 diabetes patients. PG - 122-9 LID - S0168-8227(16)00067-X [pii] LID - 10.1016/j.diabres.2016.01.018 [doi] AB - AIM: The association between thyroid stimulating hormone (TSH) and type 2 diabetes mellitus (T2DM) is well known. However, whether TSH is related to diabetic peripheral neuropathy (DPN) has not been studied. The aim of this study was to explore the relationship between TSH and DPN in Chinese patients with T2DM. METHODS: In this cross-sectional study, 605 patients with T2DM were enrolled. Subclinical hypothyroidism (SCH) was defined as an elevated TSH level (>4.0mIU/L) and a normal free thyroxine level. DPN was evaluated by neurological symptoms, neurological signs, and electromyogram. RESULTS: Serum TSH levels were significantly higher in DPN and signs of DPN compared with non-DPN T2DM patients (both P<0.01).The prevalence of DPN and signs of DPN in SCH subjects was higher than that in euthyroid subjects (both P<0.01). Spearman's correlation analysis showed that the serum TSH level was positively associated with DPN (r=0.172, P<0.01). A significant independent association between TSH and DPN was found by multiple logistic regression analysis after adjusting for potential confounding variables [odds ratio (OR)=1.365, P<0.01]. The patients were sequentially assigned to quartiles according to TSH level. Compared with quartile 1, patients in quartile 2 (P<0.01), quartile 3 (P=0.01), and quartile 4 (P<0.01) had a higher risk of DPN. Receiver-operating characteristic curve analysis revealed that the optimal cutoff point of TSH to indicate DPN was 3.045mIU/L in men and 2.94mIU/L in women. CONCLUSION: TSH level is independently associated with DPN in Chinese population with T2DM. A high serum TSH level may be a potential risk factor for DPN. CI - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved. FAU - Zhao, Weijing AU - Zhao W AD - Department of Endocrinology & Metabolism, Shanghai Key Laboratory of Diabetes, Shanghai Jiao-Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Medical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Diseases, Shanghai Institute for Diabetes, Shanghai, China. FAU - Zeng, Hui AU - Zeng H AD - Department of Endocrinology & Metabolism, Shanghai Key Laboratory of Diabetes, Shanghai Jiao-Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Medical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Diseases, Shanghai Institute for Diabetes, Shanghai, China. FAU - Zhang, Xiaoyan AU - Zhang X AD - Department of Endocrinology & Metabolism, Shanghai Key Laboratory of Diabetes, Shanghai Jiao-Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Medical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Diseases, Shanghai Institute for Diabetes, Shanghai, China. FAU - Liu, Fengjing AU - Liu F AD - Department of Endocrinology & Metabolism, Shanghai Key Laboratory of Diabetes, Shanghai Jiao-Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Medical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Diseases, Shanghai Institute for Diabetes, Shanghai, China. FAU - Pan, Jiemin AU - Pan J AD - Department of Endocrinology & Metabolism, Shanghai Key Laboratory of Diabetes, Shanghai Jiao-Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Medical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Diseases, Shanghai Institute for Diabetes, Shanghai, China. FAU - Zhao, Jungong AU - Zhao J AD - Department of Interventional Radiology, Shanghai Jiao-Tong University Affiliated Sixth People's Hospital, Shanghai, China. FAU - Zhao, Jun AU - Zhao J AD - Department of Vascular Surgery, Shanghai Jiao-Tong University Affiliated Sixth People's Hospital, Shanghai, China. FAU - Li, Lianxi AU - Li L AD - Department of Endocrinology & Metabolism, Shanghai Key Laboratory of Diabetes, Shanghai Jiao-Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Medical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Diseases, Shanghai Institute for Diabetes, Shanghai, China. FAU - Bao, Yuqian AU - Bao Y AD - Department of Endocrinology & Metabolism, Shanghai Key Laboratory of Diabetes, Shanghai Jiao-Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Medical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Diseases, Shanghai Institute for Diabetes, Shanghai, China. FAU - Liu, Fang AU - Liu F AD - Department of Endocrinology & Metabolism, Shanghai Key Laboratory of Diabetes, Shanghai Jiao-Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Medical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Diseases, Shanghai Institute for Diabetes, Shanghai, China. Electronic address: f-liu@sjtu.edu.cn. FAU - Jia, Weiping AU - Jia W AD - Department of Endocrinology & Metabolism, Shanghai Key Laboratory of Diabetes, Shanghai Jiao-Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Medical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Diseases, Shanghai Institute for Diabetes, Shanghai, China. Electronic address: wpjia@sjtu.edu.cn. LA - eng PT - Journal Article DEP - 20160119 PL - Ireland TA - Diabetes Res Clin Pract JT - Diabetes research and clinical practice JID - 8508335 RN - 0 (Biomarkers) RN - 9002-71-5 (Thyrotropin) RN - Q51BO43MG4 (Thyroxine) SB - IM MH - Aged MH - Biomarkers/blood MH - China/epidemiology MH - Cross-Sectional Studies MH - Diabetes Mellitus, Type 2/blood/*complications MH - Diabetic Neuropathies/*blood/epidemiology/etiology MH - Female MH - Humans MH - Hypothyroidism/*blood/complications MH - Male MH - Middle Aged MH - Odds Ratio MH - Prevalence MH - ROC Curve MH - Retrospective Studies MH - Risk Factors MH - Thyrotropin/*blood MH - Thyroxine/blood OTO - NOTNLM OT - Diabetic peripheral neuropathy OT - Subclinical hypothyroidism OT - Thyroid stimulating hormone OT - Type 2 diabetes mellitus EDAT- 2016/01/30 06:00 MHDA- 2016/12/15 06:00 CRDT- 2016/01/30 06:00 PHST- 2015/07/14 00:00 [received] PHST- 2015/10/13 00:00 [revised] PHST- 2016/01/07 00:00 [accepted] PHST- 2016/01/30 06:00 [entrez] PHST- 2016/01/30 06:00 [pubmed] PHST- 2016/12/15 06:00 [medline] AID - S0168-8227(16)00067-X [pii] AID - 10.1016/j.diabres.2016.01.018 [doi] PST - ppublish SO - Diabetes Res Clin Pract. 2016 May;115:122-9. doi: 10.1016/j.diabres.2016.01.018. Epub 2016 Jan 19.