PMID- 26822373
OWN - NLM
STAT- MEDLINE
DCOM- 20170206
LR  - 20200330
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 26
IP  - 10
DP  - 2016 Oct
TI  - Regional thermochemotherapy versus hepatic arterial infusion chemotherapy for 
      palliative treatment of advanced hilar cholangiocarcinoma: a retrospective 
      controlled study.
PG  - 3500-9
LID - 10.1007/s00330-016-4208-7 [doi]
AB  - OBJECTIVES: To retrospectively assess the efficacy of regional thermochemotherapy 
      (TCT) compared with hepatic arterial infusion chemotherapy (HAIC)-alone for 
      palliative treatment of advanced hilar cholangiocarcinoma (HC) and to determine 
      the prognostic factors associated with survival. METHODS: Forty-three consecutive 
      patients with advanced HC underwent regional TCT (TCT group) and HAIC (HAIC 
      group). We analyzed baseline characteristics, overall survival (OS), 
      progression-free survival (PFS), stent patency time (SPT), adverse events (AEs), 
      and prognostic factors for OS between the two groups. RESULTS: OS of patients 
      treated with regional TCT was significantly longer compared to that of patients 
      treated with HAIC (median OS: 20.3 vs. 13.2 months, P = 0.004), and SPT and PFS 
      were significantly increased in the TCT group compared with the HAIC group 
      (median SPT: 26.5 vs. 10.5 months, P < 0.001; median PFS: 16.5 vs. 10.2 months, 
      P = 0.001). TCT and metal stent insertion were two independent prognostic factors 
      associated with survival. The treatment-related AEs were tolerable and similar in 
      the two groups, except for hilar pain (34.6 %) and skin rashes (24.6 %) in the 
      TCT group. CONCLUSIONS: Our results show that regional TCT is safe and more 
      effective than HAIC-alone and may be a promising option for palliative treatment 
      of advanced HC. Metal stenting before TCT appears to improve patients' OS. KEY 
      POINTS: * Regional TCT is a novel combination for palliative treatment of 
      advanced HC * Our data showed significantly promising outcomes in the TCT group * 
      HC patients with metal stenting appeared to derive greater benefit from TCT.
FAU - Chen, Yaoting
AU  - Chen Y
AD  - Department of Interventional Radiology, Sun Yat-sen Memorial Hospital, Sun 
      Yat-sen University, No. 107, Yanjiang Road West, Yuexiu Region, Guangzhou, 
      Guangdong, 510120, People's Republic of China.
AD  - Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene 
      Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 
      Yanjiang Road West, Guangzhou, Guangdong, 510120, People's Republic of China.
FAU - Li, Huiqing
AU  - Li H
AD  - Health Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107 
      Yanjiang Road West, Guangzhou, Guangdong, 510120, People's Republic of China.
FAU - Jiang, Xiongying
AU  - Jiang X
AD  - Department of Interventional Radiology, Sun Yat-sen Memorial Hospital, Sun 
      Yat-sen University, No. 107, Yanjiang Road West, Yuexiu Region, Guangzhou, 
      Guangdong, 510120, People's Republic of China.
AD  - Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene 
      Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 
      Yanjiang Road West, Guangzhou, Guangdong, 510120, People's Republic of China.
FAU - Chen, Dong
AU  - Chen D
AD  - Department of Interventional Radiology, Sun Yat-sen Memorial Hospital, Sun 
      Yat-sen University, No. 107, Yanjiang Road West, Yuexiu Region, Guangzhou, 
      Guangdong, 510120, People's Republic of China.
AD  - Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene 
      Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 
      Yanjiang Road West, Guangzhou, Guangdong, 510120, People's Republic of China.
FAU - Ni, Jiayan
AU  - Ni J
AD  - Department of Interventional Radiology, Sun Yat-sen Memorial Hospital, Sun 
      Yat-sen University, No. 107, Yanjiang Road West, Yuexiu Region, Guangzhou, 
      Guangdong, 510120, People's Republic of China.
AD  - Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene 
      Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 
      Yanjiang Road West, Guangzhou, Guangdong, 510120, People's Republic of China.
FAU - Sun, Hongliang
AU  - Sun H
AD  - Department of Interventional Radiology, Sun Yat-sen Memorial Hospital, Sun 
      Yat-sen University, No. 107, Yanjiang Road West, Yuexiu Region, Guangzhou, 
      Guangdong, 510120, People's Republic of China.
AD  - Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene 
      Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 
      Yanjiang Road West, Guangzhou, Guangdong, 510120, People's Republic of China.
FAU - Luo, Jianghong
AU  - Luo J
AD  - Department of Interventional Radiology, Sun Yat-sen Memorial Hospital, Sun 
      Yat-sen University, No. 107, Yanjiang Road West, Yuexiu Region, Guangzhou, 
      Guangdong, 510120, People's Republic of China.
AD  - Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene 
      Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 
      Yanjiang Road West, Guangzhou, Guangdong, 510120, People's Republic of China.
FAU - Yao, Herui
AU  - Yao H
AD  - Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene 
      Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 
      Yanjiang Road West, Guangzhou, Guangdong, 510120, People's Republic of China. 
      yaoherui@163.com.
AD  - Department of Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 
      No. 107 Yanjiang Road West, Guangzhou, Guangdong, 510120, People's Republic of 
      China. yaoherui@163.com.
FAU - Xu, Linfeng
AU  - Xu L
AD  - Department of Interventional Radiology, Sun Yat-sen Memorial Hospital, Sun 
      Yat-sen University, No. 107, Yanjiang Road West, Yuexiu Region, Guangzhou, 
      Guangdong, 510120, People's Republic of China. xulinfeng_sysh@163.com.
AD  - Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene 
      Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 
      Yanjiang Road West, Guangzhou, Guangdong, 510120, People's Republic of China. 
      xulinfeng_sysh@163.com.
LA  - eng
PT  - Clinical Study
PT  - Comparative Study
PT  - Journal Article
DEP - 20160128
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
RN  - Q20Q21Q62J (Cisplatin)
RN  - U3P01618RT (Fluorouracil)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antineoplastic Combined Chemotherapy Protocols/*administration & dosage/adverse 
      effects/therapeutic use
MH  - Bile Duct Neoplasms/*therapy
MH  - Cisplatin/administration & dosage
MH  - Combined Modality Therapy
MH  - Disease-Free Survival
MH  - Female
MH  - Fluorouracil/administration & dosage
MH  - Humans
MH  - Hyperthermia, Induced/*methods
MH  - Infusions, Intra-Arterial
MH  - Klatskin Tumor/*therapy
MH  - Male
MH  - Middle Aged
MH  - Palliative Care/*methods
MH  - Prognosis
MH  - Retrospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Efficacy
OT  - Hilar cholangiocarcinoma
OT  - Prognostic factor
OT  - Thermochemotherapy
OT  - Treatment
EDAT- 2016/01/30 06:00
MHDA- 2017/02/07 06:00
CRDT- 2016/01/30 06:00
PHST- 2015/05/23 00:00 [received]
PHST- 2016/01/08 00:00 [accepted]
PHST- 2015/10/12 00:00 [revised]
PHST- 2016/01/30 06:00 [entrez]
PHST- 2016/01/30 06:00 [pubmed]
PHST- 2017/02/07 06:00 [medline]
AID - 10.1007/s00330-016-4208-7 [pii]
AID - 10.1007/s00330-016-4208-7 [doi]
PST - ppublish
SO  - Eur Radiol. 2016 Oct;26(10):3500-9. doi: 10.1007/s00330-016-4208-7. Epub 2016 Jan 
      28.