PMID- 26823203
OWN - NLM
STAT- MEDLINE
DCOM- 20170116
LR  - 20220409
IS  - 1755-3768 (Electronic)
IS  - 1755-375X (Linking)
VI  - 94
IP  - 6
DP  - 2016 Sep
TI  - Indocyanine green angiographic findings in initial-onset acute 
      Vogt-Koyanagi-Harada disease.
PG  - 573-8
LID - 10.1111/aos.12974 [doi]
AB  - PURPOSE: To study the features of Indocyanine green angiography (ICGA) in 
      patients with initial-onset acute Vogt-Koyanagi-Harada (VKH) disease. METHODS: 
      Retrospective cohort study of ICGA performed with the use of Heidelberg scanning 
      laser ophthalmoscope on a consecutive series of patients with initial-onset acute 
      VKH disease. The following signs were analysed: choroidal perfusion 
      inhomogeneity, early hyperfluorescent stromal vessels, hypofluorescent dark dots 
      (HDDs), fuzzy or lost pattern of large stromal choroidal vessels, disc 
      hyperfluorescence, and, diffuse late choroidal hyperfluorescence. In addition, we 
      looked for any new ICGA findings. RESULTS: Thirty-six patients (72 eyes) from a 
      single academic institution were studied. The following findings were identified: 
      HDDs in all eyes (100%), fuzzy or lost pattern of large stromal vessels in all 
      eyes (100%), early hyperfluorescent stromal vessels were seen in 60 eyes (83%), 
      diffuse late choroidal hyperfluorescence was present in 51 eyes (71%), choroidal 
      perfusion inhomogeneity was seen in 44 eyes (61%), disc hyperfluorescence was 
      seen in 25 cases (69%), and choroidal folds were present in only six eyes. New 
      ICGA findings detected in this study were hypofluorescent patches corresponding 
      to areas of exudative retinal detachment in 60 eyes (83%) and 'starry sky' 
      pattern of late widespread punctate choroidal hyperfluorescence in 37 eyes (51%). 
      CONCLUSIONS: The most prevalent ICGA findings were HDDs, fuzzy stromal vessels 
      and early hyperfluorescent stromal vessels in patients with initial-onset acute 
      VKH disease. Novel ICGA findings in this group of patients included 
      hypofluorescent patches corresponding to areas of exudative retinal detachment, 
      and late widespread punctate choroidal hyperfluorescence taking on a 'starry sky' 
      pattern.
CI  - (c) 2016 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & 
      Sons Ltd.
FAU - Abouammoh, Marwan A
AU  - Abouammoh MA
AD  - Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, 
      Saudi Arabia.
FAU - Gupta, Vishali
AU  - Gupta V
AD  - Department of Ophthalmology, Advanced Eye Center, Postgraduate Institute of 
      Medical Education and Research, Chandigarh, India.
FAU - Hemachandran, Suhail
AU  - Hemachandran S
AD  - Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, 
      Saudi Arabia.
FAU - Herbort, Carl P
AU  - Herbort CP
AD  - Inflammatory and Retinal Eye Diseases, Centre for Ophthalmic Specialized Care, 
      Lausanne, Switzerland.
AD  - Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland.
FAU - Abu El-Asrar, Ahmed M
AU  - Abu El-Asrar AM
AD  - Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, 
      Saudi Arabia.
AD  - Dr. Nasser Al-Rashid Research Chair in Ophthalmology, King Saud University, 
      Riyadh, Saudi Arabia.
LA  - eng
PT  - Journal Article
DEP - 20160129
PL  - England
TA  - Acta Ophthalmol
JT  - Acta ophthalmologica
JID - 101468102
RN  - 0 (Coloring Agents)
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Choroid/blood supply
MH  - Choroid Diseases/*diagnosis
MH  - Coloring Agents/administration & dosage
MH  - Female
MH  - *Fluorescein Angiography
MH  - Humans
MH  - Hyperemia/*diagnosis
MH  - Indocyanine Green/*administration & dosage
MH  - Male
MH  - Middle Aged
MH  - Ophthalmoscopy
MH  - Optic Nerve Diseases/*diagnosis
MH  - Retinal Detachment/*diagnosis
MH  - Retrospective Studies
MH  - Uveomeningoencephalitic Syndrome/*diagnosis
MH  - Visual Acuity/physiology
OTO - NOTNLM
OT  - Vogt-Koyanagi-Harada disease
OT  - imaging
OT  - indocyanine green angiography
OT  - uveitis
EDAT- 2016/01/30 06:00
MHDA- 2017/01/17 06:00
CRDT- 2016/01/30 06:00
PHST- 2015/11/03 00:00 [received]
PHST- 2015/11/29 00:00 [accepted]
PHST- 2016/01/30 06:00 [entrez]
PHST- 2016/01/30 06:00 [pubmed]
PHST- 2017/01/17 06:00 [medline]
AID - 10.1111/aos.12974 [doi]
PST - ppublish
SO  - Acta Ophthalmol. 2016 Sep;94(6):573-8. doi: 10.1111/aos.12974. Epub 2016 Jan 29.