PMID- 26823397 OWN - NLM STAT- MEDLINE DCOM- 20170504 LR - 20180203 IS - 1468-2079 (Electronic) IS - 0007-1161 (Linking) VI - 100 IP - 10 DP - 2016 Oct TI - Relationship of retinal vascular calibre and diabetic retinopathy in Chinese patients with type 2 diabetes mellitus: the Desheng Diabetic Eye Study. PG - 1359-65 LID - 10.1136/bjophthalmol-2014-306078 [doi] AB - AIMS: To describe the relationship of retinal arteriolar and venular calibre with diabetic retinopathy (DR) and related risk factors, including glucose levels and other biomarkers in a Chinese population with type 2 diabetes mellitus (T2DM). METHODS: A cross-sectional study. Patients with T2DM were recruited from a local community in urban Beijing. Seven fields 30 degrees colour fundus photographs were taken and examined for the presence and severity of DR using a standardised grading system. Retinal vascular calibres were measured and expressed as average central retinal arteriolar and venular equivalent using a computer-based program. RESULTS: A total of 1340 patients with T2DM were included for analysis. Of these, 472 (35.22%) had DR. Wider retinal venular calibre, but not arteriolar calibre, was associated with increasing glucose and glycosylated haemoglobin A1c levels (p<0.006) and dyslipidaemia (p for trend <0.05). After adjusting for possible covariates, the higher quartile of retinal venular calibre was associated with higher prevalence of any DR (OR 2, 95% CI 1.36 to 2.95). Venular calibre increased from 224.33 mum in those without retinopathy to 231.21 mum in those with mild, 241.01 mum in those with moderate and 235.65 mum in those with severe retinopathy (p for trend <0.001). Arteriolar calibre was not associated with DR. CONCLUSIONS: In the current study, wider venular calibre, but not arteriolar calibre, was shown to be associated with development and increased severity of DR independently from other risk factors in a Chinese diabetic population. CI - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ FAU - Yang, Xiufen AU - Yang X AD - Department of Ophthalmology, The Friendship Hospital, Capital Medical University, Beijing, China Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. FAU - Deng, Yu AU - Deng Y AD - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. FAU - Gu, Hong AU - Gu H AD - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. FAU - Ren, Xuetao AU - Ren X AD - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China Sekwa Research Institute, Beijing, China. FAU - Lim, Apiradee AU - Lim A AD - Department of Mathematics and Computer Science, Faculty of Science and Technology, Prince of Songkla University, Muang Pattani, Thailand. FAU - Snellingen, Torkel AU - Snellingen T AD - Sekwa Research Institute, Beijing, China. FAU - Liu, Xipu AU - Liu X AD - Sekwa Research Institute, Beijing, China. FAU - Wang, Ningli AU - Wang N AD - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. FAU - Won Pak, Jeong AU - Won Pak J AD - Department of Ophthalmology and Visual Sciences, Fundus Photograph Reading Center, University of Wisconsin, Madison, Wisconsin, USA. FAU - Liu, Ningpu AU - Liu N AD - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. FAU - Danis, Ronald P AU - Danis RP AD - Department of Ophthalmology and Visual Sciences, Fundus Photograph Reading Center, University of Wisconsin, Madison, Wisconsin, USA. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20160128 PL - England TA - Br J Ophthalmol JT - The British journal of ophthalmology JID - 0421041 SB - IM MH - China/epidemiology MH - Cross-Sectional Studies MH - Diabetes Mellitus, Type 2/*complications/diagnosis/epidemiology MH - Diabetic Retinopathy/*diagnosis/epidemiology/etiology MH - Female MH - Humans MH - Incidence MH - Male MH - Middle Aged MH - Photography MH - Retinal Artery/*diagnostic imaging MH - Retinal Vein/*diagnostic imaging MH - Severity of Illness Index MH - Surveys and Questionnaires OTO - NOTNLM OT - Diagnostic tests/Investigation OT - Epidemiology OT - Imaging OT - Physiology OT - Retina EDAT- 2016/01/30 06:00 MHDA- 2017/05/05 06:00 CRDT- 2016/01/30 06:00 PHST- 2015/08/19 00:00 [received] PHST- 2015/12/24 00:00 [accepted] PHST- 2016/01/30 06:00 [entrez] PHST- 2016/01/30 06:00 [pubmed] PHST- 2017/05/05 06:00 [medline] AID - bjophthalmol-2014-306078 [pii] AID - 10.1136/bjophthalmol-2014-306078 [doi] PST - ppublish SO - Br J Ophthalmol. 2016 Oct;100(10):1359-65. doi: 10.1136/bjophthalmol-2014-306078. Epub 2016 Jan 28.