PMID- 26823832
OWN - NLM
STAT- MEDLINE
DCOM- 20161101
LR  - 20190109
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 8
IP  - 11
DP  - 2015
TI  - Down-regulation of microRNA-126 and microRNA-133b acts as novel predictor 
      biomarkers in progression and metastasis of non small cell lung cancer.
PG  - 14983-8
AB  - OBJECTIVE: MiRNAs play crucial roles in progression of cancer. However, the 
      underlying mechanisms of miRNAs in non small cell lung cancer are still poorly 
      understood. The aim of this study was to investigate the expression level of 
      microRNA-126 (miR-126) and microRNA-133b (miR-133b) and also their association 
      with clinicopathological features in patients with non small cell lung cancer 
      (NSCLC). METHODS: Total RNA was purified from NSCLC tissues and adjacent 
      non-tumor tissues and then quantitative real-time PCR (qRT-PCR) was used to 
      evaluate the expression rate of microRNAs. Furthermore, the association of 
      miR-126 and miR-133b level with clinicopathological features and prognosis were 
      evaluated. RESULTS: Our findings showed that expression of miR-126 was decreased 
      in NSCLC tissues compared with adjacent non-tumor tissues. On the other hand, a 
      lower expression of miR-133b was seen in NSCLC tissues when compared with 
      adjacent non-tumor tissues. In term of miR-126, our results showed that miR-126 
      was associated with tumor stage and lymph nodes metastasis (P<0.05). In term of 
      miR-133b, our finding indicated that decreased expression of miR-133b was 
      correlated with advanced tumor stage and lymph nodes metastasis (P<0.05). 
      Kaplan-Meier analysis and log-rank test indicated that patients with low 
      expression of miR-126 and miR-133b had a shorter overall survival (log-rank test; 
      P<0.05). Multivariate Cox proportional hazards model revealed that low expression 
      of miR-126 and miR-133b, advanced tumor stage and lymph nodes metastasis were 
      independent prognostic factors for overall survival of NSCLC patients. 
      CONCLUSIONS: These findings suggested that miR-126 and miR-133b might play a key 
      role in the progression and metastasis of NSCLC and would be applied as a novel 
      therapeutic agent.
FAU - Chen, Shu-Wen
AU  - Chen SW
AD  - Department of Respiratory Medicine, Luoyang Center Hospital Affiliated to 
      Zhengzhou University Luoyang 471009, China.
FAU - Wang, Tong-Bing
AU  - Wang TB
AD  - Department of Respiratory Medicine, Luoyang Center Hospital Affiliated to 
      Zhengzhou University Luoyang 471009, China.
FAU - Tian, Yu-Heng
AU  - Tian YH
AD  - Department of Respiratory Medicine, Luoyang Center Hospital Affiliated to 
      Zhengzhou University Luoyang 471009, China.
FAU - Zheng, You-Guang
AU  - Zheng YG
AD  - Department of Respiratory Medicine, Luoyang Center Hospital Affiliated to 
      Zhengzhou University Luoyang 471009, China.
LA  - eng
PT  - Journal Article
DEP - 20151101
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (MIRN126 microRNA, human)
RN  - 0 (MIRN133 microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/*analysis
MH  - Carcinoma, Non-Small-Cell Lung/genetics/mortality/*pathology
MH  - Disease Progression
MH  - Disease-Free Survival
MH  - Down-Regulation
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Lung Neoplasms/genetics/mortality/*pathology
MH  - Lymphatic Metastasis/genetics/pathology
MH  - Male
MH  - MicroRNAs
MH  - Middle Aged
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Real-Time Polymerase Chain Reaction
PMC - PMC4713618
OTO - NOTNLM
OT  - Non small cell lung cancer
OT  - microRNA-126
OT  - microRNA-133b
OT  - prognosis
EDAT- 2016/01/30 06:00
MHDA- 2016/11/02 06:00
PMCR- 2015/11/01
CRDT- 2016/01/30 06:00
PHST- 2015/09/28 00:00 [received]
PHST- 2015/10/28 00:00 [accepted]
PHST- 2016/01/30 06:00 [entrez]
PHST- 2016/01/30 06:00 [pubmed]
PHST- 2016/11/02 06:00 [medline]
PHST- 2015/11/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2015 Nov 1;8(11):14983-8. eCollection 2015.