PMID- 26824709
OWN - NLM
STAT- MEDLINE
DCOM- 20161031
LR  - 20180816
IS  - 1421-9697 (Electronic)
IS  - 0250-6807 (Linking)
VI  - 68
IP  - 2
DP  - 2016
TI  - Bioactive Components in Human Milk Along the First Month of Life: Effects of 
      Iodine Supplementation during Pregnancy.
PG  - 130-6
LID - 10.1159/000443800 [doi]
AB  - BACKGROUND/AIMS: Human milk is considered the most suitable food for infants. The 
      potential benefits of breastfeeding can be explained by the presence of different 
      growth and neurotrophic factors in human milk. This study was designed to detect 
      some biomarkers in human milk, which could be involved in the infant 
      neurodevelopment and in the regulation of the maturation of neonatal intestine 
      (brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic 
      factor (GDNF), glial fibrillary acidic protein (GFAP), fibroblast growth factor 
      21 (FGF21), lysophosphatidic acid (LPA) and autotaxin (ATX)), and compare them on 
      the basis of the consumption of iodine supplements or multivitamins. METHODS: A 
      prospective study included 37 healthy breastfeeding mothers, divided into 3 
      different groups: (1) 10 mothers who did not take supplements, (2) 17 mothers who 
      took potassium iodine (KI) 200 microg/day and (3) 10 mothers who took a multivitamin 
      supplement. RESULTS: The concentrations of BDNF, GDNF, GFAP, FGF21, LPA and ATX 
      in human milk were not significantly different in women who took a multivitamin 
      or KI supplement compared with those who did not take any supplement. 
      CONCLUSIONS: The presence of neurotrophic factors in human milk is neither 
      modified by the consumption of supplements nor by their type.
CI  - (c) 2016 S. Karger AG, Basel.
FAU - Velasco, Ines
AU  - Velasco I
AD  - Pediatrics, Obstetrics and Gynecology Unit, Riotinto Hospital, Andalusian Health 
      Service, Huelva, Spain.
FAU - Santos, Cristina
AU  - Santos C
FAU - Limon, Juan
AU  - Limon J
FAU - Pascual, Elena
AU  - Pascual E
FAU - Zarza, Lucia
AU  - Zarza L
FAU - Marina, Elena
AU  - Marina E
FAU - Gutierrez-Repiso, Carolina
AU  - Gutierrez-Repiso C
FAU - Garcia-Fuentes, Eduardo
AU  - Garcia-Fuentes E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160130
PL  - Switzerland
TA  - Ann Nutr Metab
JT  - Annals of nutrition & metabolism
JID - 8105511
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (GDNF protein, human)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Lysophospholipids)
RN  - 0 (fibroblast growth factor 21)
RN  - 1C4QK22F9J (Potassium Iodide)
RN  - 62031-54-3 (Fibroblast Growth Factors)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 9679TC07X4 (Iodine)
RN  - PG6M3969SG (lysophosphatidic acid)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/analysis
MH  - Breast Feeding
MH  - Dietary Supplements
MH  - Female
MH  - Fibroblast Growth Factors/analysis
MH  - Glial Cell Line-Derived Neurotrophic Factor/analysis
MH  - Glial Fibrillary Acidic Protein/analysis
MH  - Humans
MH  - Infant, Newborn
MH  - Iodine/analysis/*therapeutic use
MH  - Lysophospholipids/analysis
MH  - Male
MH  - Milk, Human/*chemistry
MH  - Potassium Iodide
MH  - Pregnancy/*metabolism
MH  - Prospective Studies
EDAT- 2016/01/30 06:00
MHDA- 2016/11/01 06:00
CRDT- 2016/01/30 06:00
PHST- 2015/09/28 00:00 [received]
PHST- 2016/01/06 00:00 [accepted]
PHST- 2016/01/30 06:00 [entrez]
PHST- 2016/01/30 06:00 [pubmed]
PHST- 2016/11/01 06:00 [medline]
AID - 000443800 [pii]
AID - 10.1159/000443800 [doi]
PST - ppublish
SO  - Ann Nutr Metab. 2016;68(2):130-6. doi: 10.1159/000443800. Epub 2016 Jan 30.