PMID- 26825347
OWN - NLM
STAT- MEDLINE
DCOM- 20161102
LR  - 20181113
IS  - 1473-558X (Electronic)
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 27
IP  - 4
DP  - 2016 Mar 2
TI  - Altered resting-state ascending/descending pathways associated with the posterior 
      thalamus in migraine without aura.
PG  - 257-63
LID - 10.1097/WNR.0000000000000529 [doi]
AB  - This study aimed to investigate the dysfunctional ascending/descending pain 
      pathways at the thalamic level in patients with migraine without aura (MWoA) 
      using the effective connectivity analysis of the resting-state functional MRI. 
      Twenty MWoA and 25 matched healthy controls participated in the resting-state 
      functional MRI scans. The directional interactions between the posterior thalamus 
      (PTH) and other brain regions were investigated using the Granger causality 
      analysis and choosing bilateral PTH as two individual seeds. Pearson's 
      correlation analysis was carried out between the abnormal effective connectivity 
      and the headache duration and pain intensity of MWoA. Compared with healthy 
      controls, MWoA showed decreased inflows to the bilateral PTH from the 
      ventromedial prefrontal cortex and the left precuneus/posterior cingulate cortex, 
      decreased outflow from the left PTH to the ipsilateral dorsomedial prefrontal 
      cortex, and increased inflow to the right PTH from the ipsilateral dorsolateral 
      prefrontal cortex. In addition, the abnormal inflows to the right PTH from the 
      ventromedial prefrontal cortex and the right dorsolateral prefrontal cortex 
      correlated positively with the headache duration and pain intensity, 
      respectively. The abnormal ascending/descending pain pathways between the 
      thalamus and these cortical regions indicate a disrupted pain modulation in 
      affective and sensory domains, which suggests a disequilibrium of pain inhibition 
      and facilitation in MWoA. These findings may help to shed light on the 
      pathophysiologic mechanisms of migraine.
FAU - Wang, Ting
AU  - Wang T
AD  - aDepartment of Medical Information Engineering, School of Electrical Engineering 
      and Information, Sichuan University bDepartment of Radiology, Huaxi MR Research 
      Center (HMRRC) cDepartment of Neurology, West China Hospital of Sichuan 
      University dDepartment of Psychology, School of Public Administration, Sichuan 
      University, Chengdu, People's Republic of China eNeuroimaging Center, University 
      of Maryland, College Park, Maryland.
FAU - Zhan, Wang
AU  - Zhan W
FAU - Chen, Qin
AU  - Chen Q
FAU - Chen, Ning
AU  - Chen N
FAU - Zhang, Junpeng
AU  - Zhang J
FAU - Liu, Qi
AU  - Liu Q
FAU - He, Li
AU  - He L
FAU - Zhang, Junran
AU  - Zhang J
FAU - Huang, Hua
AU  - Huang H
FAU - Gong, Qiyong
AU  - Gong Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
SB  - IM
MH  - Adult
MH  - Female
MH  - Gyrus Cinguli/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Migraine without Aura/*physiopathology
MH  - Neural Pathways/physiopathology
MH  - Parietal Lobe/physiopathology
MH  - Prefrontal Cortex/physiopathology
MH  - Rest
MH  - Severity of Illness Index
MH  - Signal Processing, Computer-Assisted
MH  - Thalamus/*physiopathology
MH  - Young Adult
PMC - PMC4750503
EDAT- 2016/01/31 06:00
MHDA- 2016/11/03 06:00
PMCR- 2016/02/11
CRDT- 2016/01/31 06:00
PHST- 2016/01/31 06:00 [entrez]
PHST- 2016/01/31 06:00 [pubmed]
PHST- 2016/11/03 06:00 [medline]
PHST- 2016/02/11 00:00 [pmc-release]
AID - 10.1097/WNR.0000000000000529 [doi]
PST - ppublish
SO  - Neuroreport. 2016 Mar 2;27(4):257-63. doi: 10.1097/WNR.0000000000000529.