PMID- 2682567
OWN - NLM
STAT- MEDLINE
DCOM- 19891130
LR  - 20080620
IS  - 0032-3756 (Print)
IS  - 0032-3756 (Linking)
VI  - 44
IP  - 7-8
DP  - 1989 Feb 13-20
TI  - [Human leukocyte antigen (HLA) complex and anti-thyroidal antibodies in Graves' 
      disease].
PG  - 179-81
AB  - The study aimed at: 1) assessing occurrence of HLA-A, HLA-B and HLA-C antigens in 
      patients with Graves' disease in comparison with control group of healthy 
      individuals; 2) determining relationship between circulating serum antimicrosomal 
      and antithyroglobulin antibodies and selected HLA complex antigens. Human 
      leukocyte antigens A, B, and C were detected with serological technique using 
      cytotoxicity test. Thyroidal antimicrosomal and antithyroglobulin antibodies were 
      titrated with radioimmunological solid phase technique while anti-membrane 
      antibodies with immunoenzyme technique. The study involved 50 patients with 
      Graves' disease and 50 healthy individuals. HLA-B8, HLA-B15, HLA-B35, and HLA-Cw3 
      antibodies were detected more frequently in patients with Graves' disease than in 
      the healthy individuals. Antimicrosomal and antithyroglobulin antibodies were 
      detected in the same group in 76% and 58% of patients, respectively whereas 
      anti-membrane antibodies in 92% of patients. Comparison of the occurrence of 
      thyroidal antimicrosomal and antithyroglobulin antibodies with the presence of 
      HLA-B8, HLA-B35, HLA-B15, and HLA-Cw3 antigens did not show statistically 
      significant correlation between these two parameters.
FAU - Lacka, K
AU  - Lacka K
FAU - Kordel, M
AU  - Kordel M
FAU - Gembicki, M
AU  - Gembicki M
LA  - pol
PT  - English Abstract
PT  - Journal Article
TT  - Uklad HLA a przeciwciala przeciwtarczycowe w chorobie Gravesa-Basedowa.
PL  - Poland
TA  - Pol Tyg Lek
JT  - Polski tygodnik lekarski (Warsaw, Poland : 1960)
JID - 9705468
RN  - 0 (Autoantibodies)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (anti-thyroglobulin)
SB  - IM
MH  - Adult
MH  - Autoantibodies
MH  - Female
MH  - Graves Disease/*immunology
MH  - HLA Antigens/*analysis
MH  - HLA-A Antigens/analysis
MH  - HLA-B Antigens/analysis
MH  - HLA-C Antigens/analysis
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Male
MH  - Middle Aged
EDAT- 1989/02/13 00:00
MHDA- 1989/02/13 00:01
CRDT- 1989/02/13 00:00
PHST- 1989/02/13 00:00 [pubmed]
PHST- 1989/02/13 00:01 [medline]
PHST- 1989/02/13 00:00 [entrez]
PST - ppublish
SO  - Pol Tyg Lek. 1989 Feb 13-20;44(7-8):179-81.