PMID- 26825855
OWN - NLM
STAT- MEDLINE
DCOM- 20180119
LR  - 20211204
IS  - 1360-0443 (Electronic)
IS  - 0965-2140 (Print)
IS  - 0965-2140 (Linking)
VI  - 111
IP  - 7
DP  - 2016 Jul
TI  - Assessing sample representativeness in randomized controlled trials: application 
      to the National Institute of Drug Abuse Clinical Trials Network.
PG  - 1226-34
LID - 10.1111/add.13327 [doi]
AB  - AIMS: To compare the characteristics of individuals participating in randomized 
      controlled trials (RCTs) of treatments of substance use disorder (SUD) with 
      individuals receiving treatment in usual care settings, and to provide a summary 
      quantitative measure of differences between characteristics of these two groups 
      of individuals using propensity score methods. Design Analyses using data from 
      RCT samples from the National Institute of Drug Abuse Clinical Trials Network 
      (CTN) and target populations of patients drawn from the Treatment Episodes Data 
      Set-Admissions (TEDS-A). Settings Multiple clinical trial sites and nation-wide 
      usual SUD treatment settings in the United States. PARTICIPANTS: A total of 3592 
      individuals from 10 CTN samples and 1 602 226 individuals selected from TEDS-A 
      between 2001 and 2009. Measurements The propensity scores for enrolling in the 
      RCTs were computed based on the following nine observable characteristics: sex, 
      race/ethnicity, age, education, employment status, marital status, admission to 
      treatment through criminal justice, intravenous drug use and the number of prior 
      treatments. Findings The proportion of those with >/= 12 years of education and the 
      proportion of those who had full-time jobs were significantly higher among RCT 
      samples than among target populations (in seven and nine trials, respectively, at 
      P < 0.001). The pooled difference in the mean propensity scores between the RCTs 
      and the target population was 1.54 standard deviations and was statistically 
      significant at P < 0.001. CONCLUSIONS: In the United States, individuals 
      recruited into randomized controlled trials of substance use disorder treatments 
      appear to be very different from individuals receiving treatment in usual care 
      settings. Notably, RCT participants tend to have more years of education and a 
      greater likelihood of full-time work compared with people receiving care in usual 
      care settings.
CI  - (c) 2016 Society for the Study of Addiction.
FAU - Susukida, Ryoko
AU  - Susukida R
AD  - Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 
      Baltimore, MD, USA.
FAU - Crum, Rosa M
AU  - Crum RM
AD  - Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 
      Baltimore, MD, USA.
AD  - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 
      Baltimore, MD, USA.
AD  - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School 
      of Medicine, Baltimore, MD, USA.
FAU - Stuart, Elizabeth A
AU  - Stuart EA
AD  - Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 
      Baltimore, MD, USA.
FAU - Ebnesajjad, Cyrus
AU  - Ebnesajjad C
AD  - Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 
      Baltimore, MD, USA.
FAU - Mojtabai, Ramin
AU  - Mojtabai R
AD  - Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 
      Baltimore, MD, USA.
AD  - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School 
      of Medicine, Baltimore, MD, USA.
LA  - eng
GR  - R01 DA036520/DA/NIDA NIH HHS/United States
GR  - UL1 TR001079/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20160401
PL  - England
TA  - Addiction
JT  - Addiction (Abingdon, England)
JID - 9304118
SB  - IM
CIN - Addiction. 2016 Jul;111(7):1141-2. PMID: 27079280
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Child
MH  - Criminal Law
MH  - *Educational Status
MH  - *Employment
MH  - *Ethnicity
MH  - Female
MH  - Humans
MH  - Male
MH  - *Marital Status
MH  - Middle Aged
MH  - National Institutes of Health (U.S.)
MH  - *Randomized Controlled Trials as Topic
MH  - Sex Distribution
MH  - Substance Abuse, Intravenous/epidemiology
MH  - Substance-Related Disorders/epidemiology/*therapy
MH  - United States/epidemiology
MH  - Young Adult
PMC - PMC4899104
MID - NIHMS756368
OTO - NOTNLM
OT  - Clinical trials
OT  - sample representativeness
OT  - substance use disorders
EDAT- 2016/01/31 06:00
MHDA- 2018/01/20 06:00
PMCR- 2017/07/01
CRDT- 2016/01/31 06:00
PHST- 2015/08/07 00:00 [received]
PHST- 2015/10/23 00:00 [revised]
PHST- 2016/01/28 00:00 [accepted]
PHST- 2016/01/31 06:00 [entrez]
PHST- 2016/01/31 06:00 [pubmed]
PHST- 2018/01/20 06:00 [medline]
PHST- 2017/07/01 00:00 [pmc-release]
AID - 10.1111/add.13327 [doi]
PST - ppublish
SO  - Addiction. 2016 Jul;111(7):1226-34. doi: 10.1111/add.13327. Epub 2016 Apr 1.