PMID- 26826427
OWN - NLM
STAT- MEDLINE
DCOM- 20161024
LR  - 20161230
IS  - 1879-0739 (Electronic)
IS  - 0271-5317 (Linking)
VI  - 36
IP  - 2
DP  - 2016 Feb
TI  - Relationship between vitamin D status and vascular complications in patients with 
      type 2 diabetes mellitus.
PG  - 117-24
LID - S0271-5317(15)00288-2 [pii]
LID - 10.1016/j.nutres.2015.11.008 [doi]
AB  - We aimed to investigate the association between serum 25-hydroxyvitamin D 
      (25[OH]D) and microvascular complications in type 2 diabetes mellitus (T2DM) 
      patients. It was hypothesized that lower 25(OH)D would be associated with 
      increased microvascular complications in T2DM. A total of 257 T2DM patients (111 
      men, 146 women) who underwent diabetic microvascular complication (peripheral 
      neuropathy, nephropathy, retinopathy) studies were recruited. Patients were 
      categorized into 3 groups according to vitamin D status: vitamin D sufficient (n 
      = 41, 25[OH]D >/= 20 ng/mL), vitamin D insufficient (n = 132, 10 </= 25[OH]D < 20 
      ng/mL), and vitamin D deficient (n = 84, 25[OH]D < 10 ng/mL). In men, the 
      prevalence of diabetic peripheral neuropathy (DPN) was significantly higher in 
      patients with vitamin D deficiency than in those with insufficiency or 
      sufficiency (38%, 11.7%, and 10%, respectively; P = .005). In addition, the 
      prevalence of diabetic nephropathy (DN) was significantly higher in women with 
      vitamin D deficiency than in the other 2 groups (40%, 20.6%, and 0%; P = .007). 
      Compared with men in the vitamin D-sufficient group (reference), men in the 
      vitamin D-deficient group had an increased risk of DPN after adjusting for 
      confounding factors (odds ratio, 7.79; 95% confidence interval, 1.52-40.05). For 
      women, when the vitamin D-sufficient group was used as a reference, those in the 
      vitamin D-deficient group had an increased risk of DN after adjusting for 
      confounding factors (odds ratio, 4.27; 95% confidence interval, 1.58-11.56). This 
      present study found that a serum 25(OH)D level less than 10 ng/mL is 
      independently associated with increased DPN in male patients and increased DN in 
      female patients with T2DM.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Jung, Chan-Hee
AU  - Jung CH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Soonchunhyang University College of Medicine, Bucheon Hospital, 1174, Jung-dong, 
      Wonmi-gu, Bucheon-si, Gyeonggi-do 420-767, Republic of Korea.
FAU - Kim, Kyu-Jin
AU  - Kim KJ
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Soonchunhyang University College of Medicine, Bucheon Hospital, 1174, Jung-dong, 
      Wonmi-gu, Bucheon-si, Gyeonggi-do 420-767, Republic of Korea.
FAU - Kim, Bo-Yeon
AU  - Kim BY
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Soonchunhyang University College of Medicine, Bucheon Hospital, 1174, Jung-dong, 
      Wonmi-gu, Bucheon-si, Gyeonggi-do 420-767, Republic of Korea.
FAU - Kim, Chul-Hee
AU  - Kim CH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Soonchunhyang University College of Medicine, Bucheon Hospital, 1174, Jung-dong, 
      Wonmi-gu, Bucheon-si, Gyeonggi-do 420-767, Republic of Korea.
FAU - Kang, Sung Koo
AU  - Kang SK
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Soonchunhyang University College of Medicine, Bucheon Hospital, 1174, Jung-dong, 
      Wonmi-gu, Bucheon-si, Gyeonggi-do 420-767, Republic of Korea.
FAU - Mok, Ji-Oh
AU  - Mok JO
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Soonchunhyang University College of Medicine, Bucheon Hospital, 1174, Jung-dong, 
      Wonmi-gu, Bucheon-si, Gyeonggi-do 420-767, Republic of Korea. Electronic address: 
      hanna@schmc.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151117
PL  - United States
TA  - Nutr Res
JT  - Nutrition research (New York, N.Y.)
JID - 8303331
RN  - 21343-40-8 (25-Hydroxyvitamin D 2)
RN  - P6YZ13C99Q (Calcifediol)
SB  - IM
MH  - 25-Hydroxyvitamin D 2/blood
MH  - Aged
MH  - Calcifediol/blood
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/*complications
MH  - Diabetic Angiopathies/complications/epidemiology/*etiology
MH  - Diabetic Nephropathies/complications/epidemiology/etiology
MH  - Diabetic Retinopathy/complications/epidemiology/etiology
MH  - Female
MH  - Hospitals, University
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - *Nutritional Status
MH  - Outpatient Clinics, Hospital
MH  - Prevalence
MH  - Republic of Korea/epidemiology
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Sex Factors
MH  - Vitamin D Deficiency/complications/epidemiology/*physiopathology
OTO - NOTNLM
OT  - Microvascular complication
OT  - Nephropathy
OT  - Peripheral neuropathy
OT  - Type 2 diabetes mellitus
OT  - Vitamin D
EDAT- 2016/01/31 06:00
MHDA- 2016/10/25 06:00
CRDT- 2016/01/31 06:00
PHST- 2015/08/14 00:00 [received]
PHST- 2015/10/24 00:00 [revised]
PHST- 2015/11/11 00:00 [accepted]
PHST- 2016/01/31 06:00 [entrez]
PHST- 2016/01/31 06:00 [pubmed]
PHST- 2016/10/25 06:00 [medline]
AID - S0271-5317(15)00288-2 [pii]
AID - 10.1016/j.nutres.2015.11.008 [doi]
PST - ppublish
SO  - Nutr Res. 2016 Feb;36(2):117-24. doi: 10.1016/j.nutres.2015.11.008. Epub 2015 Nov 
      17.