PMID- 26827719
OWN - NLM
STAT- MEDLINE
DCOM- 20160804
LR  - 20160318
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 616
DP  - 2016 Mar 11
TI  - The ventral tegmental area modulates intracortical microstimulation (ICMS)-evoked 
      M1 activity in a time-dependent manner.
PG  - 38-42
LID - S0304-3940(16)30046-5 [pii]
LID - 10.1016/j.neulet.2016.01.047 [doi]
AB  - Intracortical microstimulation (ICMS)-evoked neural activity combined with 
      ventral tegmental area (VTA) stimulation was studied in rat primary motor cortex 
      (M1). We used voltage-sensitive dye (VSD) imaging to analyze the spatiotemporal 
      dynamics of M1 activity following VTA-M1 paired stimulation. VTA stimulation was 
      preceded by M1 ICMS at inter-stimulus intervals (ISIs) of 15-350ms. VSD imaging 
      showed an excitatory-inhibitory sequence of neural activity after composing VTA 
      stimulus- and ICMS-induced M1 neural activity. To evaluate the net ICMS M1 
      response, the optical response to unpaired VTA stimulation was subtracted from 
      the VTA-M1 paired response. This revealed that the net ICMS-evoked M1 neural 
      activity was inhibited when the ISI was 30-50ms, but highly facilitated when the 
      ISI was 100-350ms. These results suggest that VTA modulates M1 excitability in 
      the order of tens to hundreds of milliseconds and might directly affect the motor 
      command generation process in the M1.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Kunori, Nobuo
AU  - Kunori N
AD  - Human Informatics Research Institute, National Institute of Advanced Industrial 
      Science and Technology, 1-1-1 Umezono, Tsukuba 305-8568, Japan; Graduate School 
      of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 
      305-8577, Japan; RIKEN Brain Science Institute, 2-1 Hirosawa, Wako 351-0198, 
      Japan.
FAU - Kajiwara, Riichi
AU  - Kajiwara R
AD  - Department of Electronics and Bioinformatics, Meiji University, Tama, Kawasaki 
      214-8571, Japan.
FAU - Takashima, Ichiro
AU  - Takashima I
AD  - Human Informatics Research Institute, National Institute of Advanced Industrial 
      Science and Technology, 1-1-1 Umezono, Tsukuba 305-8568, Japan; Graduate School 
      of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 
      305-8577, Japan. Electronic address: i.takashima@aist.go.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160128
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
SB  - IM
MH  - Animals
MH  - Brain/*physiology
MH  - Electric Stimulation
MH  - Male
MH  - Motor Cortex/*physiology
MH  - Rats, Wistar
MH  - Tegmentum Mesencephali/*physiology
MH  - Time Factors
MH  - Voltage-Sensitive Dye Imaging
OTO - NOTNLM
OT  - Intracortical microstimulation
OT  - Primary motor cortex
OT  - Ventral tegmental area
OT  - Voltage-sensitive dye imaging
EDAT- 2016/02/02 06:00
MHDA- 2016/08/05 06:00
CRDT- 2016/02/02 06:00
PHST- 2015/12/18 00:00 [received]
PHST- 2016/01/17 00:00 [revised]
PHST- 2016/01/25 00:00 [accepted]
PHST- 2016/02/02 06:00 [entrez]
PHST- 2016/02/02 06:00 [pubmed]
PHST- 2016/08/05 06:00 [medline]
AID - S0304-3940(16)30046-5 [pii]
AID - 10.1016/j.neulet.2016.01.047 [doi]
PST - ppublish
SO  - Neurosci Lett. 2016 Mar 11;616:38-42. doi: 10.1016/j.neulet.2016.01.047. Epub 
      2016 Jan 28.