PMID- 26828359
OWN - NLM
STAT- MEDLINE
DCOM- 20161108
LR  - 20190212
IS  - 1421-9778 (Electronic)
IS  - 1015-8987 (Linking)
VI  - 38
IP  - 2
DP  - 2016
TI  - The Roles of MicroRNA-141 in Human Cancers: From Diagnosis to Treatment.
PG  - 427-48
LID - 10.1159/000438641 [doi]
AB  - Cancer remains one of the most threatening causes of human health impairment, and 
      the mechanisms underlying tumorigenesis have not been completely characterized. 
      MicroRNAs (miRNAs) are a group of endogenous, small (18 approximately 25 nucleotides) 
      non-coding RNAs which negatively regulate gene expressions by directly binding to 
      the 3'-untranslated regions (3'-UTRs) of the target messenger RNAs (mRNAs). 
      Increasing evidence has demonstrated abnormal miRNA profiles and confirmed their 
      involvement in tumor initiation and progression. As one important member of the 
      miR-200 family, microRNA (miR)-141 is aberrantly expressed in many human 
      malignant tumors, participating in various cellular processes including 
      epithelial-mesenchymal transition (EMT), proliferation, migration, invasion, and 
      drug resistance. In the present review, we briefly describe the mechanisms 
      underlying miR-141-mediated tumorigenesis and the possible future of miR-141 as a 
      potential diagnostic and prognostic parameter as well as therapeutic target in 
      clinical applications.
CI  - (c) 2016 The Author(s) Published by S. Karger AG, Basel.
FAU - Gao, Yanping
AU  - Gao Y
AD  - Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing 
      University, Nanjing, China.
FAU - Feng, Bing
AU  - Feng B
FAU - Han, Siqi
AU  - Han S
FAU - Zhang, Kai
AU  - Zhang K
FAU - Chen, Jing
AU  - Chen J
FAU - Li, Chen
AU  - Li C
FAU - Wang, Rui
AU  - Wang R
FAU - Chen, Longbang
AU  - Chen L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20160201
PL  - Germany
TA  - Cell Physiol Biochem
JT  - Cellular physiology and biochemistry : international journal of experimental 
      cellular physiology, biochemistry, and pharmacology
JID - 9113221
RN  - 0 (MIRN141 microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Animals
MH  - Carcinogenesis/genetics/pathology
MH  - Epithelial-Mesenchymal Transition
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - MicroRNAs/analysis/*genetics/metabolism
MH  - Neoplasm Metastasis/diagnosis/genetics/pathology
MH  - Neoplasms/diagnosis/*genetics/*pathology
MH  - Signal Transduction
EDAT- 2016/02/02 06:00
MHDA- 2016/11/09 06:00
CRDT- 2016/02/02 06:00
PHST- 2015/11/30 00:00 [accepted]
PHST- 2016/02/02 06:00 [entrez]
PHST- 2016/02/02 06:00 [pubmed]
PHST- 2016/11/09 06:00 [medline]
AID - 000438641 [pii]
AID - 10.1159/000438641 [doi]
PST - ppublish
SO  - Cell Physiol Biochem. 2016;38(2):427-48. doi: 10.1159/000438641. Epub 2016 Feb 1.