PMID- 26828623
OWN - NLM
STAT- MEDLINE
DCOM- 20160811
LR  - 20160404
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 147
DP  - 2016 May
TI  - Occurrence and prenatal exposure to persistent organic pollutants using meconium 
      in Korea: Feasibility of meconium as a non-invasive human matrix.
PG  - 8-15
LID - S0013-9351(16)30032-9 [pii]
LID - 10.1016/j.envres.2016.01.033 [doi]
AB  - Prenatal exposure to persistent organic pollutants (POPs) is of great concern due 
      to the vulnerability of fetus. Nineteen Polychlorinated biphenyls (PCBs), 18 
      organochlorine pesticides (OCPs) including DDTs, HCHs, chlordanes, and 
      hexachlorobenzene, and 22 polybrominated diphenyl ethers (PBDEs) were measured in 
      meconium samples from 72 newborn infants using high resolution gas 
      chromatography/mass spectrometry. The median concentrations (on wet weight basis) 
      of PCBs, OCPs, and PBDEs were 26.8pg/g, 66.7pg/g, and 2.32pg/g, respectively. 
      Highly significant correlations were observed among the compounds of PCBs and 
      OCPs, suggesting their similar sources and kinetic behaviors. BDE 47 had 
      significant correlations with PCBs and OCPs, whereas BDE 209 was not correlated 
      with any of the contaminants due to different exposure sources. The 
      concentrations of p,p'-DDE, beta-HCH, and trans-nonaCHL between paired maternal 
      blood-meconium and cord blood-meconium showed significant correlations, while 
      PCBs and PBDEs were not significantly correlated in the paired samples. Maternal 
      age and gestational age were demographic parameters affecting POP levels in 
      meconium. Multiple regression analysis showed that the levels of several OCPs in 
      cord and maternal serum were contributing factors governing the levels of these 
      contaminants in meconium. Our results indicate that meconium can be utilized as a 
      human matrix for prenatal exposure to several OCPs.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Jeong, Yunsun
AU  - Jeong Y
AD  - Department of Marine Sciences and Convergent Technology, Hanyang University, 
      Ansan, Republic of Korea.
FAU - Lee, Sunggyu
AU  - Lee S
AD  - Department of Marine Sciences and Convergent Technology, Hanyang University, 
      Ansan, Republic of Korea.
FAU - Kim, Sunmi
AU  - Kim S
AD  - School of Public Health, Seoul National University, Seoul, Republic of Korea.
FAU - Choi, Sung-Deuk
AU  - Choi SD
AD  - School of Urban and Environmental Engineering, Ulsan National Institute of 
      Science and Technology, Ulsan, Republic of Korea.
FAU - Park, Jeongim
AU  - Park J
AD  - College of Natural Sciences, Soonchunhyang University, Asan, Republic of Korea.
FAU - Kim, Hai-Joong
AU  - Kim HJ
AD  - College of Medicine, Korea University, Seoul, Republic of Korea.
FAU - Lee, Jeong Jae
AU  - Lee JJ
AD  - College of Medicine, Soonchunhyang University, Seoul, Republic of Korea.
FAU - Choi, Gyuyeon
AU  - Choi G
AD  - College of Medicine, Soonchunhyang University, Seoul, Republic of Korea.
FAU - Choi, Sooran
AU  - Choi S
AD  - College of Medicine, Inha University, Incheon, Republic of korea.
FAU - Kim, Sungjoo
AU  - Kim S
AD  - College of Medicine, Hallym University, Seoul, Republic of Korea.
FAU - Kim, Su Young
AU  - Kim SY
AD  - College of Medicine, Jeju National University, Jeju, Republic of Korea.
FAU - Kim, Young Don
AU  - Kim YD
AD  - College of Medicine, Jeju National University, Jeju, Republic of Korea.
FAU - Cho, Geumjoon
AU  - Cho G
AD  - College of Medicine, Korea University, Seoul, Republic of Korea.
FAU - Suh, Eunsook
AU  - Suh E
AD  - College of Medicine, Soonchunhyang University, Seoul, Republic of Korea.
FAU - Kim, Sung Koo
AU  - Kim SK
AD  - College of Medicine, Inha University, Incheon, Republic of korea.
FAU - Eun, So-Hee
AU  - Eun SH
AD  - College of Medicine, Korea University, Seoul, Republic of Korea.
FAU - Eom, Soyong
AU  - Eom S
AD  - College of Medicine, Yonsei University, Seoul, Republic of Korea.
FAU - Kim, Seunghyo
AU  - Kim S
AD  - College of Medicine, Hallym University, Seoul, Republic of Korea.
FAU - Kim, Gun-Ha
AU  - Kim GH
AD  - College of Medicine, Korea University, Seoul, Republic of Korea.
FAU - Kim, Sungkyoon
AU  - Kim S
AD  - School of Public Health, Seoul National University, Seoul, Republic of Korea.
FAU - Choi, Kyungho
AU  - Choi K
AD  - School of Public Health, Seoul National University, Seoul, Republic of Korea.
FAU - Moon, Hyo-Bang
AU  - Moon HB
AD  - Department of Marine Sciences and Convergent Technology, Hanyang University, 
      Ansan, Republic of Korea. Electronic address: hbmoon@hanyang.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160130
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
SB  - IM
MH  - Adult
MH  - Environmental Monitoring/*methods
MH  - Environmental Pollutants/*analysis
MH  - Female
MH  - Fetus/*chemistry
MH  - Halogenated Diphenyl Ethers/analysis
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - *Maternal Exposure
MH  - Meconium/*chemistry
MH  - Regression Analysis
MH  - Republic of Korea
OTO - NOTNLM
OT  - Cord
OT  - Fetus
OT  - Maternal
OT  - Meconium
OT  - PBDE
EDAT- 2016/02/02 06:00
MHDA- 2016/08/12 06:00
CRDT- 2016/02/02 06:00
PHST- 2015/11/02 00:00 [received]
PHST- 2016/01/19 00:00 [revised]
PHST- 2016/01/22 00:00 [accepted]
PHST- 2016/02/02 06:00 [entrez]
PHST- 2016/02/02 06:00 [pubmed]
PHST- 2016/08/12 06:00 [medline]
AID - S0013-9351(16)30032-9 [pii]
AID - 10.1016/j.envres.2016.01.033 [doi]
PST - ppublish
SO  - Environ Res. 2016 May;147:8-15. doi: 10.1016/j.envres.2016.01.033. Epub 2016 Jan 
      30.