PMID- 26829307
OWN - NLM
STAT- MEDLINE
DCOM- 20161014
LR  - 20181202
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 148
DP  - 2016 Apr
TI  - Assessment of health risk from organochlorine xenobiotics in goat milk for 
      consumers in Poland.
PG  - 395-402
LID - S0045-6535(16)30025-X [pii]
LID - 10.1016/j.chemosphere.2016.01.025 [doi]
AB  - The occurrence of organochlorine xenobiotics in goat milk is a one of 
      bioindicators of environmental pollution, and, consequently, food contamination. 
      This study estimates contamination level of goat milk produced at two organic 
      farms in years 2009-2013. Analysis covered determination of 18 organochlorine 
      pesticides, including HCH isomers (alpha, beta, gamma, delta), DDT and its metabolites, 
      endosulfan and its derivatives, and methoxychlor. Pesticide content was 
      determined using GCMS method. The detected levels of organochlorine residues in 
      goat milk were low, in most cases below 8 ng g(-1) lipids. Among HCH isomers, gamma- 
      and beta-HCH occurred in the highest concentrations, up to 4.85 ng g(-1) lipids. 
      While among DDT metabolites p,p'-DDD dominated, up to 7.86 ng g(-1) lipids. The 
      detected residues were below the current maximum residue limits (MRLs) for the 
      pesticides. Considering the average milk consumption in Poland, the goat milk 
      from both farms was safe for consumers' health. The lifetime average daily dose 
      (LADD) for the sum of the compounds under study ranged within 1.73 x 10(-5)-1.06 
      x 10(-4) mg kg bw(-1) d(-1) and were well below the acceptable daily intake (ADI) 
      for particular compounds. This was also confirmed by the values of hazard 
      quotient (HQ), which were very low and ranged within 3.42 x 10(-3)-5.55 x 10(-2).
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Witczak, Agata
AU  - Witczak A
AD  - Toxicology Dep., West Pomeranian University of Technology, Szczecin, Poland. 
      Electronic address: Agata.Witczak@zut.edu.pl.
FAU - Pohorylo, Anna
AU  - Pohorylo A
AD  - Toxicology Dep., West Pomeranian University of Technology, Szczecin, Poland.
FAU - Mituniewicz-Malek, Anna
AU  - Mituniewicz-Malek A
AD  - Department of Dairy Technology and Food Storage, West Pomeranian University of 
      Technology, Szczecin, Poland.
LA  - eng
PT  - Journal Article
DEP - 20160130
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticide Residues)
RN  - 0 (Xenobiotics)
SB  - IM
MH  - Animals
MH  - Environmental Pollutants/*analysis
MH  - Food Contamination/*analysis
MH  - Goats
MH  - Hydrocarbons, Chlorinated/*analysis
MH  - Milk/*chemistry
MH  - Pesticide Residues/*analysis
MH  - Poland
MH  - Risk Assessment
MH  - Xenobiotics/*analysis
OTO - NOTNLM
OT  - Goat milk
OT  - Hazard quotient
OT  - Human health risk
OT  - Organochlorine pesticide
EDAT- 2016/02/02 06:00
MHDA- 2016/10/16 06:00
CRDT- 2016/02/02 06:00
PHST- 2015/08/29 00:00 [received]
PHST- 2015/12/10 00:00 [revised]
PHST- 2016/01/07 00:00 [accepted]
PHST- 2016/02/02 06:00 [entrez]
PHST- 2016/02/02 06:00 [pubmed]
PHST- 2016/10/16 06:00 [medline]
AID - S0045-6535(16)30025-X [pii]
AID - 10.1016/j.chemosphere.2016.01.025 [doi]
PST - ppublish
SO  - Chemosphere. 2016 Apr;148:395-402. doi: 10.1016/j.chemosphere.2016.01.025. Epub 
      2016 Jan 30.