PMID- 26829335
OWN - NLM
STAT- MEDLINE
DCOM- 20180206
LR  - 20191210
IS  - 1872-6283 (Electronic)
IS  - 0379-0738 (Linking)
VI  - 265
DP  - 2016 Aug
TI  - A study to model the post-mortem stability of 4-MMC, MDMA and BZP in putrefying 
      remains.
PG  - 54-60
LID - S0379-0738(16)00014-1 [pii]
LID - 10.1016/j.forsciint.2016.01.006 [doi]
AB  - There is currently limited data available on the stabilities of the three 
      stimulants 4-methylmethcathinone (4-MMC), 3,4-methylenedioxymethamphetamine 
      (MDMA) and N-benzylpiperazine (BZP) in a putrefying matrix. A Gas Chromatography 
      Mass Spectrometry (GC-MS) method to determine the concentration of the three 
      drugs in putrefying porcine liver over a three month period was developed and 
      validated. Both 4-MMC and BZP were found to be unstable, becoming undetectable 
      and having an average recovery of 52% respectively after one month at ambient 
      room temperature (20 degrees C). MDMA was found to be moderately stable, with an average 
      recovery of 74% after three months at room temperature. This study indicated that 
      the putrefaction process could have a significant impact on concentrations of 
      4-MMC and BZP in post-mortem cases involving putrefied remains.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Wenholz, Daniel S
AU  - Wenholz DS
AD  - Centre for Forensic Science, University of Technology Sydney (UTS), 15 Broadway, 
      Ultimo, NSW, 2007, Australia.
FAU - Luong, Susan
AU  - Luong S
AD  - Centre for Forensic Science, University of Technology Sydney (UTS), 15 Broadway, 
      Ultimo, NSW, 2007, Australia.
FAU - Philp, Morgan
AU  - Philp M
AD  - Centre for Forensic Science, University of Technology Sydney (UTS), 15 Broadway, 
      Ultimo, NSW, 2007, Australia.
FAU - Forbes, Shari L
AU  - Forbes SL
AD  - Centre for Forensic Science, University of Technology Sydney (UTS), 15 Broadway, 
      Ultimo, NSW, 2007, Australia.
FAU - Stuart, Barbara H
AU  - Stuart BH
AD  - Centre for Forensic Science, University of Technology Sydney (UTS), 15 Broadway, 
      Ultimo, NSW, 2007, Australia.
FAU - Drummer, Olaf H
AU  - Drummer OH
AD  - Department of Forensic Medicine, Monash University and Victorian Institute of 
      Forensic Medicine, 65 Kavanagh Street, Southbank, VIC, 3006, Australia.
FAU - Fu, Shanlin
AU  - Fu S
AD  - Centre for Forensic Science, University of Technology Sydney (UTS), 15 Broadway, 
      Ultimo, NSW, 2007, Australia. Electronic address: shanlin.fu@uts.edu.au.
LA  - eng
PT  - Journal Article
PT  - Validation Study
DEP - 20160116
PL  - Ireland
TA  - Forensic Sci Int
JT  - Forensic science international
JID - 7902034
RN  - 0 (Illicit Drugs)
RN  - 0 (N-benzylpiperazine)
RN  - 0 (Piperazines)
RN  - 44RAL3456C (Methamphetamine)
RN  - 8BA8T27317 (mephedrone)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Forensic Pathology
MH  - Illicit Drugs/*analysis
MH  - Methamphetamine/analogs & derivatives/analysis
MH  - Models, Animal
MH  - N-Methyl-3,4-methylenedioxyamphetamine/analysis
MH  - Piperazines/analysis
MH  - *Postmortem Changes
MH  - Reproducibility of Results
MH  - Substance Abuse Detection/methods
MH  - Swine
OTO - NOTNLM
OT  - 3,4-methylenedioxymethamphetamine
OT  - 4-methylmethcathinone
OT  - N-benzylpiperazine
OT  - Putrefactive degradation
EDAT- 2016/02/02 06:00
MHDA- 2018/02/07 06:00
CRDT- 2016/02/02 06:00
PHST- 2015/09/22 00:00 [received]
PHST- 2015/11/25 00:00 [revised]
PHST- 2016/01/08 00:00 [accepted]
PHST- 2016/02/02 06:00 [entrez]
PHST- 2016/02/02 06:00 [pubmed]
PHST- 2018/02/07 06:00 [medline]
AID - S0379-0738(16)00014-1 [pii]
AID - 10.1016/j.forsciint.2016.01.006 [doi]
PST - ppublish
SO  - Forensic Sci Int. 2016 Aug;265:54-60. doi: 10.1016/j.forsciint.2016.01.006. Epub 
      2016 Jan 16.