PMID- 26830899
OWN - NLM
STAT- MEDLINE
DCOM- 20160929
LR  - 20181202
IS  - 1573-7225 (Electronic)
IS  - 0957-5243 (Linking)
VI  - 27
IP  - 3
DP  - 2016 Mar
TI  - Dietary total antioxidant capacity in relation to endometrial cancer risk: a 
      case-control study in Italy.
PG  - 425-31
LID - 10.1007/s10552-016-0719-4 [doi]
AB  - PURPOSE: To investigate the role of the overall antioxidant activity of diet, we 
      estimated the relation between three dietary indices of total antioxidant 
      capacity (TAC) and endometrial cancer risk METHODS: We analyzed data from an 
      Italian case-control study including 454 women with incident, histologically 
      confirmed endometrial cancer, and 908 frequency-matched controls admitted to the 
      same hospitals as cases for acute non-neoplastic conditions. A reproducible and 
      valid food frequency questionnaire was used to assess subjects' habitual diet. 
      TAC was measured using Italian food composition tables in terms of 
      Ferric-reducing antioxidant power (FRAP), Trolox equivalent antioxidant capacity 
      (TEAC), and total radical-trapping antioxidant parameter (TRAP). We computed odds 
      ratios (OR) and corresponding 95 % confidence intervals (CIs) using conditional 
      multiple logistic regression models, including terms for recognized endometrial 
      cancer risk factors and total energy intake. RESULTS: TAC was inversely related 
      to endometrial cancer risk with ORs for the highest versus the lowest quartile of 
      0.69 (95 % CI 0.47-1.00) for FRAP, 0.68 (95 % CI 0.46-0.99) for TEAC, and 0.68 
      (95 % CI 0.47-0.98) for TRAP. The relations appeared consistent in strata of 
      selected risk factors and decreased when considering TAC without the contribution 
      of coffee. CONCLUSIONS: Our findings suggest a favorable role of a diet high in 
      TAC on endometrial cancer risk, which can be partially driven by coffee 
      consumption.
FAU - Rossi, Marta
AU  - Rossi M
AD  - Department of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche "Mario 
      Negri", Via Giuseppe La Masa 19, 20156, Milan, Italy. mrossi@marionegri.it.
AD  - Department of Clinical Sciences and Community Health, Universita degli Studi di 
      Milano, Via G. Venezian 1, 20133, Milan, Italy. mrossi@marionegri.it.
FAU - Tavani, Alessandra
AU  - Tavani A
AD  - Department of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche "Mario 
      Negri", Via Giuseppe La Masa 19, 20156, Milan, Italy.
FAU - Ciociola, Valentina
AU  - Ciociola V
AD  - Department of Clinical Sciences and Community Health, Universita degli Studi di 
      Milano, Via G. Venezian 1, 20133, Milan, Italy.
FAU - Ferraroni, Monica
AU  - Ferraroni M
AD  - Department of Clinical Sciences and Community Health, Universita degli Studi di 
      Milano, Via G. Venezian 1, 20133, Milan, Italy.
FAU - Parpinel, Maria
AU  - Parpinel M
AD  - Unit of Hygiene and Epidemiology, Department of Biological and Medical Sciences, 
      Universita di Udine, p.le Kolbe, 4, 33100, Udine, Italy.
FAU - Serafini, Mauro
AU  - Serafini M
AD  - Functional Food and Metabolic Stress Prevention Laboratory, Research Center on 
      Agriculture, CRA-NUT, Via Ardeatina 546, 00178, Rome, Italy.
FAU - Bellocco, Rino
AU  - Bellocco R
AD  - Department of Statistics and Quantitative Methods, Universita di Milano-Bicocca, 
      Piazza dell'Ateneo Nuovo 1, 20126, Milan, Italy.
AD  - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 
      Solnavagen 1, 171 77, Solna, Sweden.
FAU - Zucchetto, Antonella
AU  - Zucchetto A
AD  - Department of Clinical Sciences and Community Health, Universita degli Studi di 
      Milano, Via G. Venezian 1, 20133, Milan, Italy.
AD  - Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico Aviano 
      IRCCS, Via F. Gallini 2, 33080, Aviano, Italy.
FAU - Montella, Maurizio
AU  - Montella M
AD  - Epidemiology Unit, National Cancer Institute, "G. Pascale" Foundation, Via M. 
      Semmola, 80131, Naples, Italy.
FAU - Serraino, Diego
AU  - Serraino D
AD  - Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico Aviano 
      IRCCS, Via F. Gallini 2, 33080, Aviano, Italy.
FAU - Lagiou, Pagona
AU  - Lagiou P
AD  - Department of Epidemiology, Harvard School of Public Health, 677 Huntington 
      Avenue, Boston, MA, 02115, USA.
AD  - Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, 
      University of Athens, 75 M Asias Street, Goudi, 115-27, Athens, Greece.
FAU - La Vecchia, Carlo
AU  - La Vecchia C
AD  - Department of Clinical Sciences and Community Health, Universita degli Studi di 
      Milano, Via G. Venezian 1, 20133, Milan, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160201
PL  - Netherlands
TA  - Cancer Causes Control
JT  - Cancer causes & control : CCC
JID - 9100846
RN  - 0 (Antioxidants)
RN  - 0 (Coffee)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antioxidants/*administration & dosage
MH  - Case-Control Studies
MH  - Coffee
MH  - *Diet
MH  - Endometrial Neoplasms/*epidemiology
MH  - *Energy Intake
MH  - Female
MH  - Humans
MH  - Italy
MH  - Logistic Models
MH  - Middle Aged
MH  - Risk Factors
MH  - Surveys and Questionnaires
MH  - Young Adult
OTO - NOTNLM
OT  - Diet
OT  - Endometrial cancer
OT  - Non-enzymatic antioxidant capacity
OT  - Total antioxidant capacity
EDAT- 2016/02/03 06:00
MHDA- 2016/09/30 06:00
CRDT- 2016/02/03 06:00
PHST- 2015/04/15 00:00 [received]
PHST- 2016/01/12 00:00 [accepted]
PHST- 2016/02/03 06:00 [entrez]
PHST- 2016/02/03 06:00 [pubmed]
PHST- 2016/09/30 06:00 [medline]
AID - 10.1007/s10552-016-0719-4 [pii]
AID - 10.1007/s10552-016-0719-4 [doi]
PST - ppublish
SO  - Cancer Causes Control. 2016 Mar;27(3):425-31. doi: 10.1007/s10552-016-0719-4. 
      Epub 2016 Feb 1.