PMID- 26831016
OWN - NLM
STAT- MEDLINE
DCOM- 20160823
LR  - 20181202
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Linking)
VI  - 55
IP  - 3
DP  - 2016
TI  - Detection of Left Ventricular Regional Dysfunction and Myocardial Abnormalities 
      Using Complementary Cardiac Magnetic Resonance Imaging in Patients with Systemic 
      Sclerosis without Cardiac Symptoms: A Pilot Study.
PG  - 237-43
LID - 10.2169/internalmedicine.55.4441 [doi]
AB  - Objective We sought to detect the presence of left ventricular regional 
      dysfunction and myocardial abnormalities in systemic sclerosis (SSc) patients 
      without cardiac symptoms using a complementary cardiac magnetic resonance (CMR) 
      imaging approach. Methods Consecutive patients with SSc without cardiac symptoms 
      and healthy controls underwent CMR on a 1.5 T scanner. The peak systolic regional 
      function in the circumferential and radial strain (Ecc, % and Err, %) were 
      calculated using a feature tracking analysis on the mid-left ventricular slices 
      obtained with cine MRI. In addition, we investigated the myocardial 
      characteristics by contrast MRI. Pharmacological stress and rest perfusion scans 
      were performed to assess perfusion defect (PD) due to micro- or macrovascular 
      impairment, and late gadolinium enhancement (LGE) images were obtained for the 
      assessment of myocarditis and/or fibrosis. Results We compared 15 SSc patients 
      with 10 healthy controls. No statistically significant differences were observed 
      in the baseline characteristics between the patients and healthy controls. The 
      mean peak Err and Ecc of all segments was significantly lower in the patients 
      than the controls (p=0.011 and p=0.003, respectively). Four patients with LGE 
      (28.6%) and seven patients with PD (50.0%) were observed. PD was significantly 
      associated with digital ulcers (p=0.005). Utilizing a linear regression model, 
      the presence of myocardial LGE was significantly associated with the peak Ecc 
      (p=0.024). After adjusting for age, the association between myocardial LGE and 
      the peak Ecc was strengthened. Conclusion A subclinical myocardial involvement, 
      as detected by CMR, was prevalent in the SSc patients without cardiac symptoms. 
      Regional dysfunction might predict the myocardial abnormalities observed in SSc 
      patients without cardiac symptoms.
FAU - Kobayashi, Yasuyuki
AU  - Kobayashi Y
AD  - Department of Radiology, St. Marianna University School of Medicine, Japan.
FAU - Kobayashi, Hitomi
AU  - Kobayashi H
FAU - T Giles, Jon
AU  - T Giles J
FAU - Yokoe, Isamu
AU  - Yokoe I
FAU - Hirano, Masaharu
AU  - Hirano M
FAU - Nakajima, Yasuo
AU  - Nakajima Y
FAU - Takei, Masami
AU  - Takei M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20160201
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Contrast Media
MH  - Female
MH  - Fibrosis
MH  - Gadolinium DTPA
MH  - Humans
MH  - *Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Pilot Projects
MH  - Scleroderma, Systemic/*diagnosis/physiopathology
MH  - Systole
MH  - Ventricular Dysfunction, Left/*diagnosis/physiopathology
EDAT- 2016/02/03 06:00
MHDA- 2016/08/24 06:00
CRDT- 2016/02/03 06:00
PHST- 2016/02/03 06:00 [entrez]
PHST- 2016/02/03 06:00 [pubmed]
PHST- 2016/08/24 06:00 [medline]
AID - 10.2169/internalmedicine.55.4441 [doi]
PST - ppublish
SO  - Intern Med. 2016;55(3):237-43. doi: 10.2169/internalmedicine.55.4441. Epub 2016 
      Feb 1.