PMID- 26831057 OWN - NLM STAT- MEDLINE DCOM- 20170424 LR - 20181113 IS - 1875-8312 (Electronic) IS - 1569-5794 (Linking) VI - 32 Suppl 1 DP - 2016 Jun TI - Detecting cardiac involvement with magnetic resonance in patients with active eosinophilic granulomatosis with polyangiitis. PG - 155-62 LID - 10.1007/s10554-016-0843-y [doi] AB - Cardiac involvement is the most important prognostic factor in eosinophilic granulomatosis with polyangiitis (EGPA, Churg-Strauss syndrome). The aims of this study were to describe findings of cardiac magnetic resonance (CMR) in patients with active EGPA and to find factors associated with cardiac involvement detected by CMR that could help identify patients who would benefit from the examination. Medical records and CMR images in 16 consecutive EGPA patients (8 women and 8 men, median age of 47 years ranging from 34 to 68 years) were reviewed. Clinical features and results of laboratory tests were compared according to the presence of myocardial late gadolinium enhancement (LGE) on CMR images. The patients were followed for the development of cardiac symptoms and signs (mean follow up duration, 40.5 +/- 12.8 months). Among the total of 16 patients, 8 (50 %) had myocardial LGE according to CMR, located in the subendocardial layer in 7 of them (87.5 %). The extent of LGE had a significant negative correlation with left ventricular ejection fraction (LVEF, rho = -0.723, p = 0.043). The presence of LGE was associated with larger end-systolic left ventricle internal dimension (34 vs. 28 mm, p = 0.027) and presence of diastolic dysfunction (75 vs. 0 %, p = 0.008) on echocardiography, elevated NT-proBNP (75 vs. 12.5 %, p = 0.012), and elevated CK-MB (62.5 vs. 0 %, p = 0.010) compared to the group without LGE. Only one patient (6.3 %) had cardiac symptoms before CMR and another patient (6.3 %) developed heart failure 4 years later during remission. The other 14 patients remained free from cardiac signs and symptoms during the follow-up period. In patients with active EGPA, CMR enables detection of cardiac involvement when cardiac symptoms are not present. Echocardiographic diastolic dysfunction and elevated NT-proBNP or CK-MB may help identify active EGPA patients who can benefit from CMR to detect cardiac involvement without cardiac symptoms. FAU - Yune, Sehyo AU - Yune S AD - Division of Allergy, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea. FAU - Choi, Dong-Chull AU - Choi DC AD - Division of Allergy, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea. dcchoi@skku.edu. FAU - Lee, Byung-Jae AU - Lee BJ AD - Division of Allergy, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea. FAU - Lee, Jin-Young AU - Lee JY AD - Center for Health Promotion, Samsung Medical Center, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea. FAU - Jeon, Eun-Seok AU - Jeon ES AD - Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea. FAU - Kim, Sung Mok AU - Kim SM AD - Department of Radiology, Cardiovascular Imaging Center, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea. FAU - Choe, Yeon Hyeon AU - Choe YH AD - Department of Radiology, Cardiovascular Imaging Center, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea. yhchoe@skku.edu. LA - eng PT - Journal Article DEP - 20160201 PL - United States TA - Int J Cardiovasc Imaging JT - The international journal of cardiovascular imaging JID - 100969716 RN - 0 (Biomarkers) RN - 0 (Contrast Media) RN - 0 (Organometallic Compounds) RN - 0 (Peptide Fragments) RN - 0 (pro-brain natriuretic peptide (1-76)) RN - 114471-18-0 (Natriuretic Peptide, Brain) RN - 1BJ477IO2L (gadobutrol) RN - EC 2.7.3.2 (Creatine Kinase, MB Form) SB - IM MH - Adult MH - Aged MH - Biomarkers/blood MH - Cardiomyopathies/*diagnostic imaging/etiology/pathology/physiopathology MH - Churg-Strauss Syndrome/*complications/diagnosis MH - Contrast Media/administration & dosage MH - Creatine Kinase, MB Form/blood MH - Disease Progression MH - Disease-Free Survival MH - Female MH - Granulomatosis with Polyangiitis/*complications/diagnosis MH - Humans MH - *Magnetic Resonance Imaging, Cine MH - Male MH - Middle Aged MH - Myocardium/metabolism/*pathology MH - Natriuretic Peptide, Brain/blood MH - Organometallic Compounds/administration & dosage MH - Peptide Fragments/blood MH - Predictive Value of Tests MH - Retrospective Studies MH - Stroke Volume MH - Time Factors MH - Ventricular Function, Left OTO - NOTNLM OT - Cardiac magnetic resonance OT - Churg-Strauss syndrome OT - Eosinophilic granulomatosis with polyangiitis OT - Vasculitis EDAT- 2016/02/03 06:00 MHDA- 2017/04/25 06:00 CRDT- 2016/02/03 06:00 PHST- 2015/09/24 00:00 [received] PHST- 2016/01/19 00:00 [accepted] PHST- 2016/02/03 06:00 [entrez] PHST- 2016/02/03 06:00 [pubmed] PHST- 2017/04/25 06:00 [medline] AID - 10.1007/s10554-016-0843-y [pii] AID - 10.1007/s10554-016-0843-y [doi] PST - ppublish SO - Int J Cardiovasc Imaging. 2016 Jun;32 Suppl 1:155-62. doi: 10.1007/s10554-016-0843-y. Epub 2016 Feb 1.