PMID- 26831846
OWN - NLM
STAT- MEDLINE
DCOM- 20161104
LR  - 20161230
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Linking)
VI  - 37
IP  - 1
DP  - 2016 Jan-Feb
TI  - Birch allergy and oral allergy syndrome: The practical relevance of serum 
      immunoglobulin E to Bet v 1.
PG  - 43-9
LID - 10.2500/aap.2016.37.3914 [doi]
AB  - BACKGROUND: Birch allergy (BA) may frequently be associated with fruit-vegetables 
      oral allergy syndrome (OAS). Bet v 1 is the major birch allergen. Previously, it 
      was reported that serum-specific immunoglobulin E (IgE) level could differentiate 
      allergy from sensitization. Thus, this study aimed to investigate the practical 
      role of Bet v 1 IgE. METHODS: A total of 245 subjects (128 women, 117 men; mean 
      age, 41 years) with suspected allergic rhinitis and sensitization to Bet v 1 were 
      evaluated. Serum IgE to Bet v 1 was assessed by using immuno-enzymatic. BA and 
      OAS were diagnosed according to validated criteria. Symptom severity perception 
      was measured by the visual analog scale. RESULTS: A total of 158 patients (64.5%) 
      had BA. Patients with BA had higher serum Bet v 1 IgE levels than subjects who 
      were sensitized (p < 0.0001). A cutoff value of 8.94 kUA/L predicted BA (area 
      under the curve, 0.76; odds ratio, 6.18). Fifty-three patients with BA (33.5%) 
      had OAS. Patients positive for OAS had higher Bet v 1 levels (p < 0.0001) and 
      more-severe symptoms (p < 0.0001) than patients with BA and negative for OAS. A 
      cutoff value of 17.4 kUA/L predicted OAS (area under the curve, 0.59; odds ratio, 
      3.19). CONCLUSIONS: The present study demonstrated that serum IgE levels to Bet v 
      1 could be a useful marker for differentiating between different birch pollen 
      sensitization phenotypes.
FAU - Ciprandi, Giorgio
AU  - Ciprandi G
AD  - Allergy Department, Istituto di Ricovero e Cura a Carattere Scientifico-Azienda 
      Ospedaliera-Universitaria San Martino, Genoa, Italy.
FAU - Comite, Paola
AU  - Comite P
FAU - Ferrero, Francesca
AU  - Ferrero F
FAU - Bignardi, Donatella
AU  - Bignardi D
FAU - Minale, Paola
AU  - Minale P
FAU - Voltolini, Susanna
AU  - Voltolini S
FAU - Troise, Costantino
AU  - Troise C
FAU - Mussap, Michele
AU  - Mussap M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Allergens)
RN  - 0 (Antigens, Plant)
RN  - 126161-14-6 (Bet v 1 allergen, Betula)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Allergens/*immunology
MH  - Antigens, Plant/*immunology
MH  - Betula/*immunology
MH  - Cross Reactions/*immunology
MH  - Diagnosis, Differential
MH  - Female
MH  - Food Hypersensitivity/blood/*diagnosis/*immunology
MH  - Humans
MH  - Immunoglobulin E/blood/immunology
MH  - Male
MH  - Middle Aged
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Rhinitis, Allergic, Seasonal/blood/*diagnosis/*immunology
MH  - Young Adult
EDAT- 2016/02/03 06:00
MHDA- 2016/11/05 06:00
CRDT- 2016/02/03 06:00
PHST- 2016/02/03 06:00 [entrez]
PHST- 2016/02/03 06:00 [pubmed]
PHST- 2016/11/05 06:00 [medline]
AID - 10.2500/aap.2016.37.3914 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2016 Jan-Feb;37(1):43-9. doi: 10.2500/aap.2016.37.3914.