PMID- 26832344
OWN - NLM
STAT- MEDLINE
DCOM- 20170629
LR  - 20220317
IS  - 1559-0100 (Electronic)
IS  - 1355-008X (Linking)
VI  - 53
IP  - 2
DP  - 2016 Aug
TI  - Association of SLC30A8 gene polymorphism with type 2 diabetes, evidence from 46 
      studies: a meta-analysis.
PG  - 381-94
LID - 10.1007/s12020-016-0870-4 [doi]
AB  - The solute carrier family 30 member 8 (SLC30A8) gene may be involved in the 
      development of type 2 diabetes mellitus (T2DM) through disrupting beta-cell 
      function. The aim of this study was to assess the association between SLC30A8 
      rs13266634 polymorphism and susceptibility to T2DM. We searched all reports 
      regarding the association between SLC30A8 rs13266634 polymorphism and T2DM risk 
      through Pubmed, Embase, and the Cochrane Library for English language reports and 
      Chongqing VIP database, Wanfang data, CBMDisc, and CNKI for Chinese language 
      studies. Allelic and genotype comparisons between cases and controls were 
      evaluated, and odds ratios with 95 % confidence intervals were used to assess the 
      strength of their association. A random effects model was selected. Publication 
      bias was estimated using Begg's test. Forty-six studies were included in the 
      analysis with a total of 71,890 cases and 96,753 controls. This meta-analysis 
      suggests that SLC30A8 (rs13266634) polymorphism was associated with T2DM risk. 
      Although previous meta-analyses have shown that this association was only found 
      in Asian and European groups, and not in African populations, our analysis 
      revealed the deleterious effect of SLC30A8 rs13266634 on T2DM in an African 
      population when stratified by ethnicity under additive model even with a small 
      number of studies.
FAU - Fan, Mengdi
AU  - Fan M
AD  - Department of Pathology, The Second Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, Zhejiang, China.
FAU - Li, Weimin
AU  - Li W
AD  - Department of Ultrasonography, The Second Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, Zhejiang, China.
FAU - Wang, Lian
AU  - Wang L
AD  - Diabetes Center and Department of Endocrinology, The Second Affiliated Hospital 
      of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
FAU - Gu, Suping
AU  - Gu S
AD  - Diabetes Center and Department of Endocrinology, The Second Affiliated Hospital 
      of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
FAU - Dong, Sisi
AU  - Dong S
AD  - Diabetes Center and Department of Endocrinology, The Second Affiliated Hospital 
      of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
FAU - Chen, Mengdie
AU  - Chen M
AD  - Diabetes Center and Department of Endocrinology, The Second Affiliated Hospital 
      of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
FAU - Yin, Haimin
AU  - Yin H
AD  - Diabetes Center and Department of Endocrinology, The Second Affiliated Hospital 
      of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
FAU - Zheng, Jinjue
AU  - Zheng J
AD  - Department of Ultrasonography, The Second Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, Zhejiang, China.
FAU - Wu, Xiaoying
AU  - Wu X
AD  - Diabetes Center and Department of Endocrinology, The Second Affiliated Hospital 
      of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
FAU - Jin, Jian
AU  - Jin J
AD  - Diabetes Center and Department of Endocrinology, The Second Affiliated Hospital 
      of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
FAU - Jiang, Xuchao
AU  - Jiang X
AD  - Department of Pathophysiology, Obesity and Diabetes Center, Second Military 
      Medical University, Shanghai, 200433, China.
FAU - Cai, Jiao
AU  - Cai J
AD  - Department of Pathophysiology, Obesity and Diabetes Center, Second Military 
      Medical University, Shanghai, 200433, China.
FAU - Liu, Peining
AU  - Liu P
AD  - Department of Child Health, The Second Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, Zhejiang, China. liupeining366@sina.com.
FAU - Zheng, Chao
AU  - Zheng C
AD  - Diabetes Center and Department of Endocrinology, The Second Affiliated Hospital 
      of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China. 
      wallbb_1022@163.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20160201
PL  - United States
TA  - Endocrine
JT  - Endocrine
JID - 9434444
RN  - 0 (Cation Transport Proteins)
RN  - 0 (SLC30A8 protein, human)
RN  - 0 (Zinc Transporter 8)
SB  - IM
MH  - Cation Transport Proteins/*genetics
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - *Polymorphism, Single Nucleotide
MH  - Zinc Transporter 8
OTO - NOTNLM
OT  - Gene polymorphism
OT  - Meta-analysis
OT  - Susceptibility
OT  - Type 2 diabetes
EDAT- 2016/02/03 06:00
MHDA- 2017/07/01 06:00
CRDT- 2016/02/03 06:00
PHST- 2015/04/16 00:00 [received]
PHST- 2016/01/13 00:00 [accepted]
PHST- 2016/02/03 06:00 [entrez]
PHST- 2016/02/03 06:00 [pubmed]
PHST- 2017/07/01 06:00 [medline]
AID - 10.1007/s12020-016-0870-4 [pii]
AID - 10.1007/s12020-016-0870-4 [doi]
PST - ppublish
SO  - Endocrine. 2016 Aug;53(2):381-94. doi: 10.1007/s12020-016-0870-4. Epub 2016 Feb 
      1.