PMID- 26832786
OWN - NLM
STAT- MEDLINE
DCOM- 20161005
LR  - 20201209
IS  - 1464-3405 (Electronic)
IS  - 0960-894X (Linking)
VI  - 26
IP  - 5
DP  - 2016 Mar 1
TI  - Synthesis and SAR of 4-methyl-5-pentylbenzene-1,3-diol (MPBD), produced by 
      Dictyostelium discoideum.
PG  - 1428-33
LID - S0960-894X(16)30067-1 [pii]
LID - 10.1016/j.bmcl.2016.01.067 [doi]
AB  - 4-Methyl-5-pentylbenzene-1,3-diol (MPBD) is a secondary metabolite of SteelyA 
      polyketide synthase, which controls cell aggregation and spore maturation of 
      Dictyostelium discoideum. In this study, chemical synthesis of MPBD and its 
      derivatives was achieved. Structure-activity relationship (SAR) studies for 
      antimicrobial activities against Escherichia coli and Bacillus subtilis were also 
      conducted.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Murata, Chihiro
AU  - Murata C
AD  - Department of Materials and Life Sciences, Faculty of Science and Technology, 
      Sophia University, 7-1 Kioicho, Chiyoda-ku, Tokyo 102-8554, Japan.
FAU - Ogura, Tetsuhiro
AU  - Ogura T
AD  - Department of Materials and Life Sciences, Faculty of Science and Technology, 
      Sophia University, 7-1 Kioicho, Chiyoda-ku, Tokyo 102-8554, Japan.
FAU - Narita, Shuhei
AU  - Narita S
AD  - Department of Materials and Life Sciences, Faculty of Science and Technology, 
      Sophia University, 7-1 Kioicho, Chiyoda-ku, Tokyo 102-8554, Japan.
FAU - Kondo, Anna P
AU  - Kondo AP
AD  - Department of Materials and Life Sciences, Faculty of Science and Technology, 
      Sophia University, 7-1 Kioicho, Chiyoda-ku, Tokyo 102-8554, Japan.
FAU - Iwasaki, Natsumi
AU  - Iwasaki N
AD  - Department of Materials and Life Sciences, Faculty of Science and Technology, 
      Sophia University, 7-1 Kioicho, Chiyoda-ku, Tokyo 102-8554, Japan.
FAU - Saito, Tamao
AU  - Saito T
AD  - Department of Materials and Life Sciences, Faculty of Science and Technology, 
      Sophia University, 7-1 Kioicho, Chiyoda-ku, Tokyo 102-8554, Japan.
FAU - Usuki, Toyonobu
AU  - Usuki T
AD  - Department of Materials and Life Sciences, Faculty of Science and Technology, 
      Sophia University, 7-1 Kioicho, Chiyoda-ku, Tokyo 102-8554, Japan. Electronic 
      address: t-usuki@sophia.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160122
PL  - England
TA  - Bioorg Med Chem Lett
JT  - Bioorganic & medicinal chemistry letters
JID - 9107377
RN  - 0 (4-methyl-5-pentylbenzene-1,3-diol)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Resorcinols)
SB  - IM
MH  - Anti-Bacterial Agents/chemical synthesis/*chemistry/*pharmacology
MH  - Bacillus subtilis/*drug effects
MH  - Dictyostelium/*chemistry/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Escherichia coli/*drug effects
MH  - Microbial Sensitivity Tests
MH  - Molecular Structure
MH  - Resorcinols/*chemical synthesis/chemistry/*pharmacology
MH  - Structure-Activity Relationship
OTO - NOTNLM
OT  - 4-Methyl-5-pentylbenzene-1,3-diol
OT  - Antimicrobial activity
OT  - Dictyostelium discoideum
OT  - SAR study
EDAT- 2016/02/03 06:00
MHDA- 2016/10/07 06:00
CRDT- 2016/02/03 06:00
PHST- 2015/12/30 00:00 [received]
PHST- 2016/01/18 00:00 [revised]
PHST- 2016/01/22 00:00 [accepted]
PHST- 2016/02/03 06:00 [entrez]
PHST- 2016/02/03 06:00 [pubmed]
PHST- 2016/10/07 06:00 [medline]
AID - S0960-894X(16)30067-1 [pii]
AID - 10.1016/j.bmcl.2016.01.067 [doi]
PST - ppublish
SO  - Bioorg Med Chem Lett. 2016 Mar 1;26(5):1428-33. doi: 10.1016/j.bmcl.2016.01.067. 
      Epub 2016 Jan 22.