PMID- 26833191
OWN - NLM
STAT- MEDLINE
DCOM- 20161011
LR  - 20181202
IS  - 1861-0293 (Electronic)
IS  - 1340-3443 (Linking)
VI  - 70
IP  - 2
DP  - 2016 Apr
TI  - Chemical constituents with anti-allergic activity from the root of Edulis 
      Superba, a horticultural cultivar of Paeonia lactiflora.
PG  - 234-40
LID - 10.1007/s11418-016-0966-4 [doi]
AB  - The methanolic extract and its subfractions from the dried root of Edulis 
      Superba, a horticultural cultivar of Paeonia lactiflora Pallas, showed potent 
      anti-allergic effect as inhibition of immunoglobulin E (IgE)-mediated 
      degranulation in rat basophil leukemia (RBL)-2H3 cells. Bioassay-guided 
      fractionation led to the isolation of 26 compounds, including a new norneolignan 
      glycoside, paeonibenzofuran (1), together with 25 known ones (2-26). The chemical 
      structure of the new compound was elucidated on the basis of spectroscopic and 
      chemical evidences. Among the isolated compounds, mudanpioside E (5) with 
      paeoniflorin-type skeleton and quercetin (16) showed potent inhibitory activity 
      against a degranulation marker, beta-hexosaminidase release with IC50 values of 
      40.34 and 25.05 muM, respectively. A primary structure-activity relationship of 
      these components was discussed.
FAU - Shi, Yan-Hong
AU  - Shi YH
AD  - Division of Pharmacognosy, Department of Medicinal Resources, Institute of 
      Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
FAU - Zhu, Shu
AU  - Zhu S
AD  - Division of Pharmacognosy, Department of Medicinal Resources, Institute of 
      Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan. 
      szhu@inm.u-toyama.ac.jp.
FAU - Tamura, Takayuki
AU  - Tamura T
AD  - Toyama Prefectural Medicinal Plants Center, Toyama, 930-0412, Japan.
FAU - Kadowaki, Makoto
AU  - Kadowaki M
AD  - Division of Gastrointestinal Pathophysiology, Department of Bioscience, Institute 
      of Natural Medicine, University of Toyama, Toyama, 930-0194, Japan.
FAU - Wang, Zhengtao
AU  - Wang Z
AD  - The MOE Key Laboratory of Standardization of Chinese Medicines, Institute of 
      Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 
      Shanghai, 201203, China.
FAU - Yoshimatsu, Kayo
AU  - Yoshimatsu K
AD  - Research Center for Medicinal Plant Resources, National Institutes of Biomedical 
      Innovation, Health and Nutrition, Ibaraki, 305-0843, Japan.
FAU - Komatsu, Katsuko
AU  - Komatsu K
AD  - Division of Pharmacognosy, Department of Medicinal Resources, Institute of 
      Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan. 
      katsukok@inm.u-toyama.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160130
PL  - Japan
TA  - J Nat Med
JT  - Journal of natural medicines
JID - 101518405
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Bridged-Ring Compounds)
RN  - 0 (Glucosides)
RN  - 0 (Glycosides)
RN  - 0 (Monoterpenes)
RN  - 0 (Plant Extracts)
RN  - 21AIQ4EV64 (peoniflorin)
RN  - 9IKM0I5T1E (Quercetin)
RN  - EC 3.2.1.52 (beta-N-Acetylhexosaminidases)
SB  - IM
MH  - Animals
MH  - Anti-Allergic Agents/isolation & purification/*pharmacology
MH  - Biomarkers/metabolism
MH  - Bridged-Ring Compounds/analysis
MH  - Cell Line, Tumor
MH  - Glucosides/isolation & purification/pharmacology
MH  - Glycosides/pharmacology
MH  - Mast Cells/*drug effects/metabolism
MH  - Monoterpenes/isolation & purification/pharmacology
MH  - Paeonia/*chemistry/classification
MH  - Phytotherapy
MH  - Plant Extracts/chemistry/*pharmacology
MH  - Plant Roots/chemistry
MH  - Quercetin/isolation & purification/pharmacology
MH  - Rats
MH  - Species Specificity
MH  - Structure-Activity Relationship
MH  - beta-N-Acetylhexosaminidases/metabolism
OTO - NOTNLM
OT  - Anti-allergic activity
OT  - Bioactive constituents
OT  - Horticultural cultivar
OT  - Paeonia lactiflora
EDAT- 2016/02/03 06:00
MHDA- 2016/10/12 06:00
CRDT- 2016/02/03 06:00
PHST- 2015/11/18 00:00 [received]
PHST- 2016/01/05 00:00 [accepted]
PHST- 2016/02/03 06:00 [entrez]
PHST- 2016/02/03 06:00 [pubmed]
PHST- 2016/10/12 06:00 [medline]
AID - 10.1007/s11418-016-0966-4 [pii]
AID - 10.1007/s11418-016-0966-4 [doi]
PST - ppublish
SO  - J Nat Med. 2016 Apr;70(2):234-40. doi: 10.1007/s11418-016-0966-4. Epub 2016 Jan 
      30.