PMID- 26834596
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160202
LR  - 20200930
IS  - 1662-5153 (Print)
IS  - 1662-5153 (Electronic)
IS  - 1662-5153 (Linking)
VI  - 9
DP  - 2015
TI  - Extinction and Retrieval + Extinction of Conditioned Fear Differentially Activate 
      Medial Prefrontal Cortex and Amygdala in Rats.
PG  - 369
LID - 10.3389/fnbeh.2015.00369 [doi]
LID - 369
AB  - Pairing a previously neutral conditioned stimulus (CS; e.g., a tone) to an 
      aversive unconditioned stimulus (US; e.g., a footshock) leads to associative 
      learning such that the tone alone comes to elicit a conditioned response (e.g., 
      freezing). We have previously shown that an extinction session that occurs within 
      the reconsolidation window (termed retrieval + extinction) attenuates fear 
      responding and prevents the return of fear in Pavlovian fear conditioning 
      (Monfils et al., 2009). To date, the mechanisms that explain the different 
      behavioral outcomes between standard extinction and retrieval + extinction remain 
      poorly understood. Here we sought to examine the differential temporal engagement 
      of specific neural systems by these two approaches using Arc catFISH (cellular 
      compartment analysis of temporal activity using fluorescence in situ 
      hybridization (FISH)). Our results demonstrate that extinction and retrieval + 
      extinction lead to differential patterns of expression, suggesting that they 
      engage different networks. These findings provide insight into the neural 
      mechanisms that allow extinction during reconsolidation to prevent the return of 
      fear in rodents.
FAU - Lee, Hongjoo J
AU  - Lee HJ
AD  - Department of Psychology, The University of Texas at Austin Austin, TX, USA.
FAU - Haberman, Rebecca P
AU  - Haberman RP
AD  - Department of Psychological and Brain Sciences, The Johns Hopkins University 
      Baltimore, MD, USA.
FAU - Roquet, Rheall F
AU  - Roquet RF
AD  - Department of Psychology, The University of Texas at Austin Austin, TX, USA.
FAU - Monfils, Marie-H
AU  - Monfils MH
AD  - Department of Psychology, The University of Texas at AustinAustin, TX, USA; 
      Center for Learning and Memory, The University of Texas at AustinAustin, TX, USA.
LA  - eng
GR  - R01 MH091147/MH/NIMH NIH HHS/United States
GR  - R21 MH086805/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20160122
PL  - Switzerland
TA  - Front Behav Neurosci
JT  - Frontiers in behavioral neuroscience
JID - 101477952
PMC - PMC4722140
OTO - NOTNLM
OT  - Arc catFISH
OT  - extinction
OT  - fear conditioning
OT  - reconsolidation
OT  - retrieval + extinction
EDAT- 2016/02/03 06:00
MHDA- 2016/02/03 06:01
PMCR- 2015/01/01
CRDT- 2016/02/03 06:00
PHST- 2015/10/12 00:00 [received]
PHST- 2015/12/21 00:00 [accepted]
PHST- 2016/02/03 06:00 [entrez]
PHST- 2016/02/03 06:00 [pubmed]
PHST- 2016/02/03 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fnbeh.2015.00369 [doi]
PST - epublish
SO  - Front Behav Neurosci. 2016 Jan 22;9:369. doi: 10.3389/fnbeh.2015.00369. 
      eCollection 2015.