PMID- 26835260
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160202
LR  - 20200930
IS  - 2224-4344 (Print)
IS  - 2224-4344 (Electronic)
IS  - 2224-4336 (Linking)
VI  - 1
IP  - 1
DP  - 2012 Jul
TI  - A pilot trial on the treatment of gastroesophageal reflux-related cough in 
      infants.
PG  - 23-34
LID - 10.3978/j.issn.2224-4336.2012.03.03 [doi]
AB  - BACKGROUND: Diagnosing asthma in infancy is largely made on the basis of the 
      symptoms of cough and wheeze. A similar presentation can be seen in 
      neurologically normal infants with excessive gastroesophageal reflux (GER). There 
      are no randomized placebo controlled studies in infants using proton pump 
      inhibitors (PPI) alone or in addition to prokinetic agents. OBJECTIVES: The 
      primary objective was to confirm the presence of excessive GER in a population of 
      infants that also had respiratory symptoms suggestive of asthma. Second, in a 
      randomized placebo-controlled fashion, we determined whether treatment of GER 
      with bethanacol and omeprazole could improve these respiratory symptoms. METHODS: 
      Infants (n=22) with a history of chronic cough and wheeze were enrolled, if they 
      had evidence of GER by history and an abnormal pH probe or gastric emptying scan. 
      Infants were randomly allocated to four treatment groups: placebo/placebo (PP), 
      omeprazole plus bethanacol (OB), omeprazole/placebo (OP), bethanacol/placebo 
      (BP). Evaluations by clinic questionnaire and exam, home diary, and pH probe data 
      were done before, after study-medication and after open label of OB. RESULTS: 
      Nineteen children were studied. PP did not affect GER or respiratory symptoms, 
      and did not decrease GER measured by pH probe. In contrast, OB decreased GER as 
      measured by pH probe indices and parental assessment. In association, OB 
      significantly decreased daytime coughing and improved respiratory scores. No 
      adverse effects were reported. CONCLUSIONS: In infants with a clinical 
      presentation suggestive of chronic GER-related cough, the use of omeprazole and 
      bethanacol appears to be viable therapeutic option.
FAU - Adamko, Darryl J
AU  - Adamko DJ
AD  - 1 Department of Pediatrics, Divisions of Pulmonary, University of Saskatchewan, 
      Canada ; 2 Department of Pediatrics, Divisions of Pulmonary, University of 
      Alberta, Canada ; 3 Department of Pediatrics, Divisions of Gastroenterology, 
      Canada.
FAU - Majaesic, Carina M
AU  - Majaesic CM
AD  - 1 Department of Pediatrics, Divisions of Pulmonary, University of Saskatchewan, 
      Canada ; 2 Department of Pediatrics, Divisions of Pulmonary, University of 
      Alberta, Canada ; 3 Department of Pediatrics, Divisions of Gastroenterology, 
      Canada.
FAU - Skappak, Christopher
AU  - Skappak C
AD  - 1 Department of Pediatrics, Divisions of Pulmonary, University of Saskatchewan, 
      Canada ; 2 Department of Pediatrics, Divisions of Pulmonary, University of 
      Alberta, Canada ; 3 Department of Pediatrics, Divisions of Gastroenterology, 
      Canada.
FAU - Jones, Adrian B
AU  - Jones AB
AD  - 1 Department of Pediatrics, Divisions of Pulmonary, University of Saskatchewan, 
      Canada ; 2 Department of Pediatrics, Divisions of Pulmonary, University of 
      Alberta, Canada ; 3 Department of Pediatrics, Divisions of Gastroenterology, 
      Canada.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Transl Pediatr
JT  - Translational pediatrics
JID - 101649179
PMC - PMC4728850
OTO - NOTNLM
OT  - Cough
OT  - esophagus
OT  - gastroesophageal reflux
OT  - pediatric asthma
COIS- Conflicts of Interest: DJ Adamko was an AHFMR Clinical Investigator. The other 
      authors have no conflicts of interest to declare.
EDAT- 2012/07/01 00:00
MHDA- 2012/07/01 00:01
PMCR- 2012/07/01
CRDT- 2016/02/03 06:00
PHST- 2016/02/03 06:00 [entrez]
PHST- 2012/07/01 00:00 [pubmed]
PHST- 2012/07/01 00:01 [medline]
PHST- 2012/07/01 00:00 [pmc-release]
AID - tp-01-01-023 [pii]
AID - 10.3978/j.issn.2224-4336.2012.03.03 [doi]
PST - ppublish
SO  - Transl Pediatr. 2012 Jul;1(1):23-34. doi: 10.3978/j.issn.2224-4336.2012.03.03.