PMID- 26837367
OWN - NLM
STAT- MEDLINE
DCOM- 20160426
LR  - 20181202
IS  - 0254-6450 (Print)
IS  - 0254-6450 (Linking)
VI  - 36
IP  - 10
DP  - 2015 Oct
TI  - [Association between type 2 diabetes in Uygur and polymorphisms of SLC30A8 and 
      its interaction with smoking].
PG  - 1167-71
AB  - OBJECTIVE: To explore the relationship between the polymorphism of solute carrier 
      family 30, member 8 (SLC30A8) gene and type 2 diabetes mellitus (T2DM) in Uyhgur 
      in Xinjiang and further analyze the interaction between SLC30A8 gene polymorphism 
      loci and smoking. METHODS: A case control study, including 1 000 patients with 
      T2DM and 1 010 non-diabetic controls, was conducted in Xinjiang. All the subjects 
      were Uygur and the age difference between the two groups was within 3 years. 
      Physical examination and blood biochemical detection were performed to obtain 
      personal clinical parameters. Genomic DNA was extracted from peripheral blood 
      leukocytes. The single nucleotide polymorphism (SNP) of SLC30A8 of all the 
      subjects was tested by using MALDI-TOF. Statistical analyses were performed with 
      SPSS 16.0. Bootstrap method was used to calculate 95% confidence intervals of 
      RERI, AP and S. RESULTS: After adjusting BMI, SBP, TC, HDL-C and LDL-C, 
      rs13266634 of SLC30A8 gene genotype frequency and allele frequency distribution 
      had statistical differences (P<0.05). Rs13266634 of risk allele were C, OR was 
      1.194 (95% CI: 1.044-1.366). In addition, the data from genotype distribution 
      analysis under different models showed that significant association between 
      rs13266634 and T2DM in dominant model, OR was 1.640 (95% CI 1.072-2.510). The 
      product of rs13266634 with the active smoking or passive smoking had no 
      statistical significance (P>0.05) , indicating there were no multiplication 
      interaction among them. Additive interactions index of RERI, AP and S and its 95% 
      confidence interval of rs13266634 and active smoking, rs13266634 and passive 
      smoking were 0.301 (-1.314-0.712), 0.204 (-0.854-0.446), 0.612 (0.186-2.013) and 
      0.125 (-0.805-1.055), 0.052 (-0.353-0.456), 1.096 (0.500-2.403) respectively, 
      indicating there were no significant additive interaction among them. CONCLUSION: 
      Rs13666334 of SLC30A8 gene is associated with the susceptibility of T2DM in 
      Uygur, and its protective genotype might be TT. Passive smoking might increase 
      the risk of T2DM in Uygur.
FAU - Su, Yinxia
AU  - Su Y
AD  - Key Laboratory of Metabolic Diease, the First Affiliated Hospital.
FAU - Wang, Zhiqiang
AU  - Wang Z
AD  - Department of Public Health, Xinjiang Medical University, Urumqi 830011, China.
FAU - Yao, Hua
AU  - Yao H
AD  - Key Laboratory of Metabolic Diease, the First Affiliated Hospital; Email: 
      yaohua01@sina.com.
FAU - Wang, Tingting
AU  - Wang T
AD  - Department of Public Health, Xinjiang Medical University, Urumqi 830011, China.
FAU - Ma, Qi
AU  - Ma Q
AD  - Key Laboratory of Metabolic Diease, the First Affiliated Hospital.
FAU - Zhu, Jun
AU  - Zhu J
AD  - Key Laboratory of Metabolic Diease, the First Affiliated Hospital.
FAU - Wang, Shuxia
AU  - Wang S
AD  - Key Laboratory of Metabolic Diease, the First Affiliated Hospital.
FAU - Ma, Yan
AU  - Ma Y
AD  - Shayibake District Centers for Disease Control and Prevention, Urumqi.
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Liu Xing Bing Xue Za Zhi
JT  - Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
JID - 8208604
RN  - 0 (Cation Transport Proteins)
RN  - 0 (SLC30A8 protein, human)
RN  - 0 (Zinc Transporter 8)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - Cation Transport Proteins/*genetics
MH  - China/epidemiology
MH  - Diabetes Mellitus, Type 2/*epidemiology/*genetics
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Smoking/*epidemiology
MH  - Zinc Transporter 8
EDAT- 2016/02/04 06:00
MHDA- 2016/04/27 06:00
CRDT- 2016/02/04 06:00
PHST- 2016/02/04 06:00 [entrez]
PHST- 2016/02/04 06:00 [pubmed]
PHST- 2016/04/27 06:00 [medline]
PST - ppublish
SO  - Zhonghua Liu Xing Bing Xue Za Zhi. 2015 Oct;36(10):1167-71.