PMID- 26837480
OWN - NLM
STAT- MEDLINE
DCOM- 20160808
LR  - 20161126
IS  - 1532-2165 (Electronic)
IS  - 1078-5884 (Linking)
VI  - 51
IP  - 4
DP  - 2016 Apr
TI  - Clinical Outcomes of Patients with Severe Hepatic Hereditary Hemorrhagic 
      Telangiectasia After Banding of the Hepatic Artery and Banding/Ligation of 
      Branches of the Hepatic Artery.
PG  - 594-601
LID - S1078-5884(15)00894-1 [pii]
LID - 10.1016/j.ejvs.2015.12.020 [doi]
AB  - OBJECTIVE/BACKGROUND: To evaluate the effectiveness of double banding/ligation of 
      hepatic arteries in treating patients with hepatic hereditary hemorrhagic 
      telangiectasia (HHHT). METHODS: From January 2004 to December 2013, 35 patients 
      were diagnosed with HHHT, among whom 11 woman and two men with a mean +/- SD age of 
      44 +/- 9 years were treated by double hepatic artery banding/ligation for cardiac 
      insufficiency and/or portal hypertension. The outcomes were evaluated 
      prospectively by measuring clinical manifestations, imaging features, liver and 
      cardiac function, pulmonary arterial systolic pressure, and post-operative 
      complications. Quality of life was evaluated with the Short Form Health Survey 
      questionnaire. RESULTS: For each patient, the common hepatic artery and one 
      branch of the left and/or right hepatic artery were banded, and other 
      significantly dilated hepatic artery branches were ligated. No patient died after 
      surgery. Clinical symptoms were improved in all patients, although ischemic 
      cholangitis was observed in two patients and treated conservatively. Cardiac 
      function, classified per the New York Heart Association (NYHA) cardiac functional 
      grading, improved (NYHA III-IV vs. NYHA I-II); pulmonary arterial systolic 
      pressure significantly decreased in all patients (48 +/- 8 mmHg vs. 24 +/- 4 mmHg; P 
      < .001) and remained in the normal range (26 +/- 3 mmHg) at the end of follow up. 
      The levels of gamma-glutamyl transpeptidase and alkaline phosphatase decreased in 11 
      patients (144 +/- 94 U/L vs. 71 +/- 34 U/L; P = .003) and 10 patients (207 +/- 71 U/L 
      vs. 105 +/- 32 U/L; P = .001), respectively. Patients were followed up for 50 +/- 28 
      months (range 6-113 months); one death resulted from causes unrelated to surgery 
      and all dimensions of quality of life improved in all surviving patients. 
      CONCLUSIONS: This study helps to establish double hepatic artery banding/ligation 
      as an effective therapy for selected patients with HHHT.
CI  - Copyright (c) 2015 European Society for Vascular Surgery. Published by Elsevier 
      Ltd. All rights reserved.
FAU - Liu, Z-C
AU  - Liu ZC
AD  - Department of Hepatobiliary Surgery, Qilu Hospital of Shandong University, Jinan 
      250012, Shandong Province, China.
FAU - Lu, X-F
AU  - Lu XF
AD  - Department of Hepatobiliary Surgery, Qilu Hospital of Shandong University, Jinan 
      250012, Shandong Province, China; Department of General Surgery, Jinan Central 
      Hospital, Jinan 250013, Shandong Province, China.
FAU - Yang, H
AU  - Yang H
AD  - Department of Hepatobiliary Surgery, Qilu Hospital of Shandong University, Jinan 
      250012, Shandong Province, China.
FAU - Liu, H-D
AU  - Liu HD
AD  - Department of Hepatobiliary Surgery, Qilu Hospital of Shandong University, Jinan 
      250012, Shandong Province, China.
FAU - Song, X
AU  - Song X
AD  - Department of General Surgery, Shandong Provincial Hospital, Jinan 250021, 
      Shandong Province, China.
FAU - Ning, S-L
AU  - Ning SL
AD  - Department of Hepatobiliary Surgery, Qilu Hospital of Shandong University, Jinan 
      250012, Shandong Province, China.
FAU - Xu, Y-F
AU  - Xu YF
AD  - Department of Hepatobiliary Surgery, Qilu Hospital of Shandong University, Jinan 
      250012, Shandong Province, China.
FAU - Chen, Y-X
AU  - Chen YX
AD  - Department of Hepatobiliary Surgery, Qilu Hospital of Shandong University, Jinan 
      250012, Shandong Province, China. Electronic address: surgeonchenyuxin@163.com.
LA  - eng
PT  - Journal Article
DEP - 20160201
PL  - England
TA  - Eur J Vasc Endovasc Surg
JT  - European journal of vascular and endovascular surgery : the official journal of 
      the European Society for Vascular Surgery
JID - 9512728
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Heart Diseases/diagnosis/etiology/surgery
MH  - Hepatic Artery/abnormalities/diagnostic imaging/physiopathology/*surgery
MH  - Humans
MH  - Hypertension, Portal/diagnosis/etiology/surgery
MH  - Ligation
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/etiology
MH  - Quality of Life
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Telangiectasia, Hereditary 
      Hemorrhagic/complications/diagnosis/physiopathology/*surgery
MH  - Time Factors
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
MH  - *Vascular Surgical Procedures/adverse effects
OTO - NOTNLM
OT  - AVM
OT  - Arteriovenous malformations
OT  - Cardiac insufficiency
OT  - Hepatic artery
OT  - Liver
OT  - Portal hypertension
EDAT- 2016/02/04 06:00
MHDA- 2016/08/09 06:00
CRDT- 2016/02/04 06:00
PHST- 2015/04/22 00:00 [received]
PHST- 2015/12/12 00:00 [accepted]
PHST- 2016/02/04 06:00 [entrez]
PHST- 2016/02/04 06:00 [pubmed]
PHST- 2016/08/09 06:00 [medline]
AID - S1078-5884(15)00894-1 [pii]
AID - 10.1016/j.ejvs.2015.12.020 [doi]
PST - ppublish
SO  - Eur J Vasc Endovasc Surg. 2016 Apr;51(4):594-601. doi: 
      10.1016/j.ejvs.2015.12.020. Epub 2016 Feb 1.