PMID- 26837515
OWN - NLM
STAT- MEDLINE
DCOM- 20161229
LR  - 20170113
IS  - 1864-6433 (Electronic)
IS  - 0914-7187 (Linking)
VI  - 30
IP  - 4
DP  - 2016 May
TI  - Prognostic value of (18)F-fluorodeoxyglucose positron emission tomography in 
      patients with gastric neuroendocrine carcinoma and mixed adenoneuroendocrine 
      carcinoma.
PG  - 279-86
LID - 10.1007/s12149-016-1059-x [doi]
AB  - OBJECTIVE: Gastric neuroendocrine carcinomas (NEC) and mixed adenoneuroendocrine 
      carcinoma (MANEC) are very rare, aggressive tumors of the stomach. We aimed to 
      examine predictive role of pretreatment (18)F-FDG PET/CT-assessed metabolic 
      parameter of primary tumors and metastases in patients with gastric NEC and 
      MANEC. METHODS: We conducted a review of the 27 patients with histopathologically 
      confirmed NECs (n = 10) and MANEC (n = 17) of the stomach at our institution 
      between January 2005 and December 2012. All patients underwent (18)F-FDG-PET 
      examination at diagnosis. Metabolic parameters [SUVmax, SUVmean, metabolic tumor 
      volume (MTV) and total lesion glycolysis (TLG)] of the primary tumor and 
      metastases on baseline PET/CT were analyzed. RESULTS: The median follow-up 
      duration was 39.4 months (95 % CI 20.0-58.1 months) and the median overall 
      survival (OS) was 25.7 months (95 % CI 14.1-37.2 months). All gastric lesions 
      were well visualized (average SUVmax = 12.0, range 3.0-41.8). When subjects were 
      divided into two groups by ROC cut-off value of 210.9 and 612, patients with high 
      TLG in primary lesion and metastases showed poorer prognosis compared to low TLG 
      patients (P = 0.09, P = 0.002, respectively). In the sub-analysis of patients 
      with metastasis (n = 12), patients with high TLG in whole body tumor showed 
      significantly shorter OS compared to those with low TLG (31.7 +/- 11.4 vs. 
      7.2 +/- 2.1 months, P = 0.006). CONCLUSION: (18)F-FDG PET/CT is useful in 
      evaluating prognosis of advanced gastric cancer with neuroendocrine carcinoma 
      components. Baseline MTV of primary gastric cancer with metastatic disease, and 
      MTV, TLG of metastases may be prognostic markers in patients with gastric NEC and 
      MANEC.
FAU - Lim, Sun Min
AU  - Lim SM
AD  - Division of Medical Oncology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, 03722, Republic of Korea.
AD  - Division of Medical Oncology, Department of Internal Medicine, CHA Bundang 
      Medical Center, CHA University, 59 Yatap-ro, Seongnam, Gyeonggido, 13496, 
      Republic of Korea.
FAU - Kim, Hyunki
AU  - Kim H
AD  - Department of Pathology, Yonsei University College of Medicine, Seoul, Republic 
      of Korea.
FAU - Kang, Beodeul
AU  - Kang B
AD  - Division of Hematology and Medical Oncology, Department of Internal Medicine, 
      Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
FAU - Kim, Hyo Song
AU  - Kim HS
AD  - Division of Medical Oncology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, 03722, Republic of Korea.
FAU - Rha, Sun Young
AU  - Rha SY
AD  - Division of Medical Oncology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, 03722, Republic of Korea.
FAU - Noh, Sung Hoon
AU  - Noh SH
AD  - Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of 
      Korea.
FAU - Hyung, Woo Jin
AU  - Hyung WJ
AD  - Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of 
      Korea.
FAU - Cheong, Jae-Ho
AU  - Cheong JH
AD  - Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of 
      Korea.
FAU - Kim, Hyoung-Il
AU  - Kim HI
AD  - Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of 
      Korea.
FAU - Chung, Hyun Cheol
AU  - Chung HC
AD  - Division of Medical Oncology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, 03722, Republic of Korea.
FAU - Yun, Mijin
AU  - Yun M
AD  - Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul, 
      03722, Republic of Korea.
FAU - Cho, Arthur
AU  - Cho A
AD  - Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul, 
      03722, Republic of Korea. artycho@yuhs.ac.
FAU - Jung, Minkyu
AU  - Jung M
AD  - Division of Medical Oncology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, 03722, Republic of Korea. minkjung@yuhs.ac.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160202
PL  - Japan
TA  - Ann Nucl Med
JT  - Annals of nuclear medicine
JID - 8913398
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Adenocarcinoma/*diagnostic imaging/metabolism/pathology
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Neuroendocrine/*diagnostic imaging/metabolism/pathology
MH  - Female
MH  - *Fluorodeoxyglucose F18
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - *Positron Emission Tomography Computed Tomography
MH  - Prognosis
MH  - Retrospective Studies
MH  - Stomach Neoplasms/*diagnostic imaging/metabolism/pathology
MH  - Survival Analysis
OTO - NOTNLM
OT  - 18F-FDG PET/CT
OT  - Gastric
OT  - Mixed adenoneuroendocine carcinoma
OT  - Neuroendocrine carcinoma
OT  - Survival
EDAT- 2016/02/04 06:00
MHDA- 2016/12/31 06:00
CRDT- 2016/02/04 06:00
PHST- 2015/10/27 00:00 [received]
PHST- 2016/01/17 00:00 [accepted]
PHST- 2016/02/04 06:00 [entrez]
PHST- 2016/02/04 06:00 [pubmed]
PHST- 2016/12/31 06:00 [medline]
AID - 10.1007/s12149-016-1059-x [pii]
AID - 10.1007/s12149-016-1059-x [doi]
PST - ppublish
SO  - Ann Nucl Med. 2016 May;30(4):279-86. doi: 10.1007/s12149-016-1059-x. Epub 2016 
      Feb 2.