PMID- 26838430
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 150
DP  - 2016 Apr 1
TI  - A microfluidic cigarette smoke collecting platform for simultaneous sample 
      extraction and multiplex analysis.
PG  - 455-62
LID - S0039-9140(15)30580-4 [pii]
LID - 10.1016/j.talanta.2015.12.052 [doi]
AB  - In this work, we report a novel microfluidic gas collecting platform aiming at 
      simultaneous sample extraction and multiplex mass spectrometry (MS) analysis. An 
      alveolar-mimicking elastic polydimethylsiloxane (PDMS) structures was designed to 
      move dynamically driven by external pressure. The movement was well tuned both by 
      its amplitude and rhythm following the natural process of human respiration. By 
      integrating the alveolar units into arrays and assembling them to gas channels, a 
      cyclic contraction/expansion system for gas inhale and exhale was successfully 
      constructed. Upon equipping this system with a droplet array on the alveolar 
      array surface, we were able to get information of inhaled smoke in a new 
      strategy. Here, with cigarette smoke as an example, analysis of accumulation for 
      target molecules during passive smoking is taken. Relationships between the 
      breathing times, distances away from smokers and inhaled content of nicotine are 
      clarified. Further, by applying different types of extraction solvent droplets on 
      different locations of the droplet array, simultaneous extraction of nicotine, 
      formaldehyde and caproic acid in sidestream smoke (SS) are realized. Since the 
      extract droplets are spatially separated, they can be directly analyzed by MS 
      which is fast and can rid us of all complex sample separation and purification 
      steps. Combining all these merits, this small, cheap and portable platform might 
      find wide application in inhaled air pollutant analysis both in and outdoors.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Hu, Shan-Wen
AU  - Hu SW
AD  - State Key Laboratory of Analytical Chemistry for Life Science and Collaborative 
      Innovation Center of Chemistry for Life Sciences, School of Chemistry and 
      Chemical Engineering, Nanjing University, Nanjing 210023, China.
FAU - Xu, Bi-Yi
AU  - Xu BY
AD  - State Key Laboratory of Analytical Chemistry for Life Science and Collaborative 
      Innovation Center of Chemistry for Life Sciences, School of Chemistry and 
      Chemical Engineering, Nanjing University, Nanjing 210023, China.
FAU - Qiao, Shu
AU  - Qiao S
AD  - State Key Laboratory of Analytical Chemistry for Life Science and Collaborative 
      Innovation Center of Chemistry for Life Sciences, School of Chemistry and 
      Chemical Engineering, Nanjing University, Nanjing 210023, China.
FAU - Zhao, Ge
AU  - Zhao G
AD  - Zhengzhou Tobacco Institute of CNTC, Zhengzhou 450001, China.
FAU - Xu, Jing-Juan
AU  - Xu JJ
AD  - State Key Laboratory of Analytical Chemistry for Life Science and Collaborative 
      Innovation Center of Chemistry for Life Sciences, School of Chemistry and 
      Chemical Engineering, Nanjing University, Nanjing 210023, China. Electronic 
      address: xujj@nju.edu.cn.
FAU - Chen, Hong-Yuan
AU  - Chen HY
AD  - State Key Laboratory of Analytical Chemistry for Life Science and Collaborative 
      Innovation Center of Chemistry for Life Sciences, School of Chemistry and 
      Chemical Engineering, Nanjing University, Nanjing 210023, China.
FAU - Xie, Fu-Wei
AU  - Xie FW
AD  - Zhengzhou Tobacco Institute of CNTC, Zhengzhou 450001, China. Electronic address: 
      xiefuwei@sina.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151225
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
RN  - 0 (Air Pollutants)
RN  - 0 (Dimethylpolysiloxanes)
RN  - 0 (Smoke)
RN  - 0 (Tobacco Smoke Pollution)
RN  - 63148-62-9 (baysilon)
RN  - 6M3C89ZY6R (Nicotine)
RN  - 7U1EE4V452 (Carbon Monoxide)
SB  - IM
MH  - Air Pollutants/*analysis/*isolation & purification
MH  - Biomimetics
MH  - Breath Tests
MH  - Carbon Monoxide/analysis/isolation & purification
MH  - Chemical Fractionation/*instrumentation
MH  - Dimethylpolysiloxanes/chemistry
MH  - Humans
MH  - *Lab-On-A-Chip Devices
MH  - Nicotine/analysis/isolation & purification
MH  - Smoke/*analysis
MH  - Tobacco Products/*analysis
MH  - Tobacco Smoke Pollution/analysis
OTO - NOTNLM
OT  - Cigarette smoke
OT  - Gas collecting
OT  - Microfluidic chip
OT  - Nicotine detection
EDAT- 2016/02/04 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/02/04 06:00
PHST- 2015/10/27 00:00 [received]
PHST- 2015/12/12 00:00 [revised]
PHST- 2015/12/19 00:00 [accepted]
PHST- 2016/02/04 06:00 [entrez]
PHST- 2016/02/04 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S0039-9140(15)30580-4 [pii]
AID - 10.1016/j.talanta.2015.12.052 [doi]
PST - ppublish
SO  - Talanta. 2016 Apr 1;150:455-62. doi: 10.1016/j.talanta.2015.12.052. Epub 2015 Dec 
      25.