PMID- 2683937
OWN - NLM
STAT- MEDLINE
DCOM- 19891205
LR  - 20131121
IS  - 0003-4886 (Print)
IS  - 0003-4886 (Linking)
VI  - 21
IP  - 9
DP  - 1989 Sep
TI  - Effect of varying drop size on the efficacy and safety of a topical beta blocker.
PG  - 351-7
AB  - We studied the effects on efficacy and safety of varying the drop size of a 
      topical solution of levobunolol 0.5%. In a double-masked, crossover acute study, 
      we administered a single drop of either 35 microL of vehicle, or 20, 35, or 50 
      microL of levobunolol one hour before the subjects began a ten-minute treadmill 
      challenge electrocardiogram. After exercise the mean heart rate was 111 beats per 
      minute (bpm) in the vehicle group and 102 to 103 bpm in the three levobunolol 
      groups, which were significantly different from the control group but not from 
      each other. In a randomized double-masked, parallel, chronic study, 117 patients 
      with elevated intraocular pressure (IOP) instilled one of the three drop sizes of 
      levobunolol twice daily for three months. Mean decreases in IOP ranged from 5.1 
      to 6.0 mmHg in the three groups, not significantly different from each other in 
      mean IOP, heart rate, or blood pressure. We conclude that drop size in the range 
      tested had no clinically significant effect on either efficacy or safety of a 
      beta blocker such as levobunolol.
FAU - Charap, A D
AU  - Charap AD
AD  - University of California, Irvine.
FAU - Shin, D H
AU  - Shin DH
FAU - Petursson, G
AU  - Petursson G
FAU - Cinotti, D
AU  - Cinotti D
FAU - Wortham, E 4th
AU  - Wortham E 4th
FAU - Brown, R H
AU  - Brown RH
FAU - Silverstone, D E
AU  - Silverstone DE
FAU - Atkins, J M
AU  - Atkins JM
FAU - Eto, C Y
AU  - Eto CY
FAU - Lue, J C
AU  - Lue JC
AU  - et al.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PL  - United States
TA  - Ann Ophthalmol
JT  - Annals of ophthalmology
JID - 0210137
RN  - 0 (Dosage Forms)
RN  - G6317AOI7K (Levobunolol)
SB  - IM
MH  - Administration, Topical
MH  - Adult
MH  - Blood Pressure/drug effects
MH  - Dosage Forms
MH  - Dose-Response Relationship, Drug
MH  - Double-Blind Method
MH  - Electrocardiography
MH  - Exercise Test
MH  - Follow-Up Studies
MH  - Glaucoma, Open-Angle/*drug therapy
MH  - Heart Rate/drug effects
MH  - Humans
MH  - Intraocular Pressure/*drug effects
MH  - Levobunolol/*administration & dosage/adverse effects/therapeutic use
MH  - Middle Aged
MH  - Multicenter Studies as Topic
MH  - Random Allocation
MH  - Time Factors
MH  - Visual Acuity/drug effects
EDAT- 1989/09/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1989/09/01 00:00
PHST- 1989/09/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1989/09/01 00:00 [entrez]
PST - ppublish
SO  - Ann Ophthalmol. 1989 Sep;21(9):351-7.