PMID- 26840064
OWN - NLM
STAT- MEDLINE
DCOM- 20160712
LR  - 20240327
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 11
IP  - 2
DP  - 2016
TI  - Effects of MDMA Injections on the Behavior of Socially-Housed Long-Tailed 
      Macaques (Macaca fascicularis).
PG  - e0147136
LID - 10.1371/journal.pone.0147136 [doi]
LID - e0147136
AB  - 3,4-methylenedioxy-N-methyl amphetamine (MDMA) is one of the few known molecules 
      to increase human and rodent prosocial behaviors. However, this effect has never 
      been assessed on the social behavior of non-human primates. In our study, we 
      subcutaneously injected three different doses of MDMA (1.0, 1.5 or 2.0mg/kg) to a 
      group of three, socially housed, young male long-tailed macaques. More than 200 
      hours of behavioral data were recorded, during 68 behavioral sessions, by an 
      automatic color-based video device that tracked the 3D positions of each animal 
      and of a toy. This data was then categorized into 5 exclusive behaviors (resting, 
      locomotion, foraging, social contact and object play). In addition, received and 
      given social grooming was manually scored. Results show several significant 
      dose-dependent behavioral effects. At 1.5mg/kg only, MDMA induces a significant 
      increase in social grooming behavior, thus confirming the prosocial effect of 
      MDMA in macaques. Additionally, at 1.5 and 2.0 mg/kg MDMA injection substantially 
      decreases foraging behavior, which is consistent with the known anorexigenic 
      effect of this compound. Furthermore, at 2.0 mg/kg MDMA injection induces an 
      increase in locomotor behavior, which is also in accordance with its known 
      stimulant property. Interestingly, MDMA injected at 1.0mg/kg increases the rate 
      of object play, which might be interpreted as a decrease of the inhibition to 
      manipulate a unique object in presence of others, or, as an increase of the 
      intrinsic motivation to manipulate this object. Together, our results support the 
      effectiveness of MDMA to study the complex neurobiology of primates' social 
      behaviors.
FAU - Ballesta, Sebastien
AU  - Ballesta S
AD  - Centre de Neuroscience Cognitive, Centre National de la Recherche Scientifique, 
      69675 Bron, France.
AD  - Departement de Biologie Humaine, Universite Lyon 1, 69622 Villeurbanne, France.
FAU - Reymond, Gilles
AU  - Reymond G
AD  - Centre de Neuroscience Cognitive, Centre National de la Recherche Scientifique, 
      69675 Bron, France.
AD  - Departement de Biologie Humaine, Universite Lyon 1, 69622 Villeurbanne, France.
FAU - Pozzobon, Matthieu
AU  - Pozzobon M
AD  - Centre de Neuroscience Cognitive, Centre National de la Recherche Scientifique, 
      69675 Bron, France.
AD  - Departement de Biologie Humaine, Universite Lyon 1, 69622 Villeurbanne, France.
FAU - Duhamel, Jean-Rene
AU  - Duhamel JR
AD  - Centre de Neuroscience Cognitive, Centre National de la Recherche Scientifique, 
      69675 Bron, France.
AD  - Departement de Biologie Humaine, Universite Lyon 1, 69622 Villeurbanne, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160203
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Injections
MH  - *Macaca fascicularis
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage
MH  - *Social Behavior
PMC - PMC4739726
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2016/02/04 06:00
MHDA- 2016/07/13 06:00
PMCR- 2016/02/03
CRDT- 2016/02/04 06:00
PHST- 2015/06/16 00:00 [received]
PHST- 2015/12/29 00:00 [accepted]
PHST- 2016/02/04 06:00 [entrez]
PHST- 2016/02/04 06:00 [pubmed]
PHST- 2016/07/13 06:00 [medline]
PHST- 2016/02/03 00:00 [pmc-release]
AID - PONE-D-15-19082 [pii]
AID - 10.1371/journal.pone.0147136 [doi]
PST - epublish
SO  - PLoS One. 2016 Feb 3;11(2):e0147136. doi: 10.1371/journal.pone.0147136. 
      eCollection 2016.