PMID- 26840067
OWN - NLM
STAT- MEDLINE
DCOM- 20161223
LR  - 20221207
IS  - 1557-8593 (Electronic)
IS  - 1520-9156 (Linking)
VI  - 18
IP  - 4
DP  - 2016 Apr
TI  - Clinical Application of the Food Insulin Index for Mealtime Insulin Dosing in 
      Adults with Type 1 Diabetes: A Randomized Controlled Trial.
PG  - 218-25
LID - 10.1089/dia.2015.0254 [doi]
AB  - BACKGROUND: The Food Insulin Index (FII) is a novel algorithm for ranking foods 
      based on their insulin demand relative to an isoenergetic reference food. We 
      compared the effect of carbohydrate counting (CC) versus the FII algorithm for 
      estimating insulin dosage on glycemic control in type 1 diabetes. MATERIALS AND 
      METHODS: In a randomized, controlled trial, adults (n = 26) using insulin pump 
      therapy were assigned to using either traditional CC or the novel Food Insulin 
      Demand (FID) counting for 12 weeks. Subjects participated in group education and 
      individual sessions. At baseline and on completion of the trial, glycated 
      hemoglobin A1c (HbA1c), day-long glycemia (6-day continuous glucose monitoring), 
      fasting lipids, and C-reactive protein were determined. RESULTS: Changes in HbA1c 
      from baseline to 12 weeks were small and not significant in both groups (mean +/- 
      SEM; FII vs. CC, -0.1 +/- 0.1% vs. -0.3 +/- 0.2%; P = 0.855). The incremental area 
      under the curve following breakfast declined significantly among the FID counters 
      with no change in the CC group (FID vs. CC, -93 +/- 41 mmol/L/min [P = 0.043] vs. 
      4 +/- 50 mmol/L/min [P = 0.938]; between groups, P = 0.143). The mean amplitude of 
      the glycemic excursion (MAGE) was significantly reduced among the FID counters 
      (FID vs. CC, -6.1 +/- 1.0 vs. -1.3 +/- 1.0 mmol/L; P = 0.003), and only the FID 
      counters experienced a trend (-44% vs. +11%; P = 0.057) to reduced hypoglycemia. 
      CONCLUSIONS: In a 12-week pilot study, MAGE and postprandial glycemia following 
      breakfast were significantly improved with FII counting versus CC, despite no 
      significant differences in HbA1c.
FAU - Bell, Kirstine J
AU  - Bell KJ
AD  - 1 Charles Perkins Centre, The University of Sydney , Sydney, New South Wales, 
      Australia .
AD  - 2 School of Molecular Bioscience, The University of Sydney , Sydney, New South 
      Wales, Australia .
FAU - Gray, Robyn
AU  - Gray R
AD  - 3 Sydney Insulin Pump Clinic , Sydney, New South Wales, Australia .
FAU - Munns, Diane
AU  - Munns D
AD  - 3 Sydney Insulin Pump Clinic , Sydney, New South Wales, Australia .
FAU - Petocz, Peter
AU  - Petocz P
AD  - 4 Department of Statistics, Macquarie University , Sydney, New South Wales, 
      Australia .
FAU - Steil, Garry
AU  - Steil G
AD  - 5 Harvard Medical School , Boston, Massachusetts.
AD  - 6 Children's Hospital , Boston, Massachusetts.
FAU - Howard, Gabrielle
AU  - Howard G
AD  - 3 Sydney Insulin Pump Clinic , Sydney, New South Wales, Australia .
FAU - Colagiuri, Stephen
AU  - Colagiuri S
AD  - 1 Charles Perkins Centre, The University of Sydney , Sydney, New South Wales, 
      Australia .
AD  - 2 School of Molecular Bioscience, The University of Sydney , Sydney, New South 
      Wales, Australia .
FAU - Brand-Miller, Jennie C
AU  - Brand-Miller JC
AD  - 1 Charles Perkins Centre, The University of Sydney , Sydney, New South Wales, 
      Australia .
AD  - 2 School of Molecular Bioscience, The University of Sydney , Sydney, New South 
      Wales, Australia .
LA  - eng
SI  - ANZCTR/ACTRN12613001367730
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20160203
PL  - United States
TA  - Diabetes Technol Ther
JT  - Diabetes technology & therapeutics
JID - 100889084
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
CIN - Diabetes Technol Ther. 2016 Apr;18(4):213-5. PMID: 27046297
MH  - Adult
MH  - Aged
MH  - Algorithms
MH  - Combined Modality Therapy/adverse effects
MH  - Diabetes Mellitus, Type 1/*diet therapy/drug therapy
MH  - Diet, Diabetic/*methods
MH  - Feasibility Studies
MH  - Female
MH  - Food/*classification
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Hyperglycemia/*prevention & control
MH  - Hypoglycemia/chemically induced/*prevention & control
MH  - Hypoglycemic Agents/*administration & dosage/adverse effects/therapeutic use
MH  - Insulin/*administration & dosage/adverse effects/therapeutic use
MH  - Insulin Infusion Systems
MH  - Male
MH  - Meals
MH  - Middle Aged
MH  - Patient Education as Topic
MH  - Pilot Projects
MH  - Young Adult
EDAT- 2016/02/04 06:00
MHDA- 2016/12/24 06:00
CRDT- 2016/02/04 06:00
PHST- 2016/02/04 06:00 [entrez]
PHST- 2016/02/04 06:00 [pubmed]
PHST- 2016/12/24 06:00 [medline]
AID - 10.1089/dia.2015.0254 [doi]
PST - ppublish
SO  - Diabetes Technol Ther. 2016 Apr;18(4):218-25. doi: 10.1089/dia.2015.0254. Epub 
      2016 Feb 3.