PMID- 26840308
OWN - NLM
STAT- MEDLINE
DCOM- 20161020
LR  - 20210816
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 17
IP  - 2
DP  - 2016 Feb 1
TI  - Prioritization of Susceptibility Genes for Ectopic Pregnancy by Gene Network 
      Analysis.
LID - 10.3390/ijms17020191 [doi]
LID - 191
AB  - Ectopic pregnancy is a very dangerous complication of pregnancy, affecting 1%-2% 
      of all reported pregnancies. Due to ethical constraints on human biopsies and the 
      lack of suitable animal models, there has been little success in identifying 
      functionally important genes in the pathogenesis of ectopic pregnancy. In the 
      present study, we developed a random walk-based computational method named 
      TM-rank to prioritize ectopic pregnancy-related genes based on text mining data 
      and gene network information. Using a defined threshold value, we identified five 
      top-ranked genes: VEGFA (vascular endothelial growth factor A), IL8 (interleukin 
      8), IL6 (interleukin 6), ESR1 (estrogen receptor 1) and EGFR (epidermal growth 
      factor receptor). These genes are promising candidate genes that can serve as 
      useful diagnostic biomarkers and therapeutic targets. Our approach represents a 
      novel strategy for prioritizing disease susceptibility genes.
FAU - Liu, Ji-Long
AU  - Liu JL
AD  - College of Veterinary Medicine, South China Agricultural University, Guangzhou 
      510642, China. jilongliu@scau.edu.cn.
FAU - Zhao, Miao
AU  - Zhao M
AD  - College of Veterinary Medicine, South China Agricultural University, Guangzhou 
      510642, China. zm1586186423@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160201
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (ESR1 protein, human)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Algorithms
MH  - ErbB Receptors/genetics
MH  - Estrogen Receptor alpha/metabolism
MH  - Female
MH  - *Gene Regulatory Networks
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Interleukin-6/genetics
MH  - Interleukin-8/genetics
MH  - Pregnancy
MH  - Pregnancy, Ectopic/*genetics
MH  - Vascular Endothelial Growth Factor A/genetics
PMC - PMC4783925
OTO - NOTNLM
OT  - ectopic pregnancy
OT  - gene prioritization
OT  - pathogenesis
OT  - text mining
EDAT- 2016/02/04 06:00
MHDA- 2016/10/21 06:00
PMCR- 2016/02/01
CRDT- 2016/02/04 06:00
PHST- 2015/12/14 00:00 [received]
PHST- 2016/01/14 00:00 [revised]
PHST- 2016/01/27 00:00 [accepted]
PHST- 2016/02/04 06:00 [entrez]
PHST- 2016/02/04 06:00 [pubmed]
PHST- 2016/10/21 06:00 [medline]
PHST- 2016/02/01 00:00 [pmc-release]
AID - ijms17020191 [pii]
AID - ijms-17-00191 [pii]
AID - 10.3390/ijms17020191 [doi]
PST - epublish
SO  - Int J Mol Sci. 2016 Feb 1;17(2):191. doi: 10.3390/ijms17020191.