PMID- 26841802
OWN - NLM
STAT- MEDLINE
DCOM- 20160819
LR  - 20210202
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Linking)
VI  - 127
IP  - 14
DP  - 2016 Apr 7
TI  - Should IGHV status and FISH testing be performed in all CLL patients at 
      diagnosis? A systematic review and meta-analysis.
PG  - 1752-60
LID - 10.1182/blood-2015-10-620864 [doi]
AB  - Since the first description of the natural history of chronic lymphocytic 
      leukemia (CLL) by David Galton in 1966, the considerable heterogeneity in the 
      disease course has been well recognized. The Rai and Binet staging systems 
      described  approximately 40 years ago have proven to be robust prognostic tools. Over the past 
      2 decades, several novel biological, genetic, and molecular markers have been 
      shown to be useful adjuncts to the Rai and Binet staging systems. In this 
      systematic review, we examined the role of immunoglobulin heavy-chain variable 
      region gene (IGHV) mutation status and genetic abnormalities determined by 
      interphase fluorescence in situ hybridization (FISH) in patients with newly 
      diagnosed CLL. The cumulative evidence presented in this systematic review is 
      sufficient to recommend that FISH and IGHV be performed as standard clinical 
      tests for all patients with newly diagnosed CLL in those countries with the 
      resources to do so. In addition to clinical stage, these parameters could 
      represent the minimal standard initial prognostic evaluation for patients with 
      CLL. This approach will allow the application of powerful, recently developed 
      prognostic indices (all of which are dependent on IGHV and FISH results) to all 
      patients with newly diagnosed CLL.
CI  - (c) 2016 by The American Society of Hematology.
FAU - Parikh, Sameer A
AU  - Parikh SA
AD  - Division of Hematology and.
FAU - Strati, Paolo
AU  - Strati P
AD  - Division of Hematology and.
FAU - Tsang, Mazie
AU  - Tsang M
AD  - Division of Hematology and.
FAU - West, Colin P
AU  - West CP
AD  - Division of General Internal Medicine, Department of Medicine, and Division of 
      Biomedical Statistics and Informatics, Department of Health Sciences Research, 
      Mayo Clinic, Rochester, MN.
FAU - Shanafelt, Tait D
AU  - Shanafelt TD
AD  - Division of Hematology and.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20160203
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Immunoglobulin Heavy Chains)
RN  - 0 (Immunoglobulin Variable Region)
SB  - IM
MH  - Female
MH  - Humans
MH  - Immunoglobulin Heavy Chains/*genetics
MH  - Immunoglobulin Variable Region/*genetics
MH  - *In Situ Hybridization, Fluorescence
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*diagnosis/*genetics
MH  - Male
MH  - Prognosis
EDAT- 2016/02/05 06:00
MHDA- 2016/08/20 06:00
CRDT- 2016/02/05 06:00
PHST- 2015/10/23 00:00 [received]
PHST- 2016/01/19 00:00 [accepted]
PHST- 2016/02/05 06:00 [entrez]
PHST- 2016/02/05 06:00 [pubmed]
PHST- 2016/08/20 06:00 [medline]
AID - S0006-4971(20)30276-7 [pii]
AID - 10.1182/blood-2015-10-620864 [doi]
PST - ppublish
SO  - Blood. 2016 Apr 7;127(14):1752-60. doi: 10.1182/blood-2015-10-620864. Epub 2016 
      Feb 3.