PMID- 26842212
OWN - NLM
STAT- MEDLINE
DCOM- 20161013
LR  - 20161230
IS  - 1998-4774 (Electronic)
IS  - 0019-509X (Linking)
VI  - 51
IP  - 4
DP  - 2014 Oct-Dec
TI  - Effect of aged garlic extract on immune responses to experimental fibrosarcoma 
      tumor in BALB/c mice.
PG  - 609-13
LID - 10.4103/0019-509X.175359 [doi]
AB  - BACKGROUND: Aged garlic extract (AGE) has many biological activities including 
      radical scavenging, antioxidative and immunomodulative effects. AIM: In this 
      research work, the antitumor and immunomodulatory effects of AGE against 
      fibrosarcoma implanted tumor were studied. MATERIALS AND METHODS: WEHI-164 
      fibrosarcoma cells were implanted subcutaneously on day 0 into the right flank of 
      40 BALB/c mice at age of 8 weeks. Mice were randomly categorized in two separate 
      groups: First received AGE (100 mg/kg, IP), second group as the control group 
      received phosphate buffered saline. Treatments were carried out 3 times/week. 
      Tumor growth was measured and morbidity was recorded. Subpopulations of CD4+/CD8+ 
      T cells were determined using flow cytometry. WEHI-164 cell specific cytotoxicity 
      of splenocytes and in vitro production of interferon gamma (IFN-gamma) and 
      interleukin-4 cytokines were measured. RESULTS: The mice received AGE had 
      significantly longer survival time compared with the control mice. The inhibitory 
      effect on tumor growth was seen in AGE treated mice. The CD4+/CD8+ ratio and in 
      vitro IFN-gamma production of splenocytes were significantly increased in AGE group. 
      WEHI-164 specific cytotoxicity of splenocytes from AGE mice was also 
      significantly increased at 25:1 E: T ratio. CONCLUSION: Administration of AGE 
      resulted in improved immune responses against experimentally implanted 
      fibrosarcoma tumors in BALB/c mice. AGE showed significant effects on inhibition 
      of tumor growth and longevity of survival times.
FAU - Tabari, M Abouhosseini
AU  - Tabari MA
AD  - Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, 
      Amol, Iran.
FAU - Ebrahimpour, S
AU  - Ebrahimpour S
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Cancer
JT  - Indian journal of cancer
JID - 0112040
RN  - 0 (Antioxidants)
RN  - 0 (Plant Extracts)
RN  - 207137-56-2 (Interleukin-4)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Antioxidants/*therapeutic use
MH  - CD4 Lymphocyte Count
MH  - CD8-Positive T-Lymphocytes
MH  - Cell Line, Tumor
MH  - Cytotoxicity Tests, Immunologic
MH  - Female
MH  - Fibrosarcoma/blood/*drug therapy
MH  - *Garlic
MH  - Immunomodulation/*drug effects
MH  - Interferon-gamma/metabolism
MH  - Interleukin-4/metabolism
MH  - Mice, Inbred BALB C
MH  - *Phytotherapy
MH  - Plant Extracts/*therapeutic use
EDAT- 2014/10/01 00:00
MHDA- 2016/10/14 06:00
CRDT- 2016/02/05 06:00
PHST- 2016/02/05 06:00 [entrez]
PHST- 2014/10/01 00:00 [pubmed]
PHST- 2016/10/14 06:00 [medline]
AID - IndianJournalofCancer_2014_51_4_609_175359 [pii]
AID - 10.4103/0019-509X.175359 [doi]
PST - ppublish
SO  - Indian J Cancer. 2014 Oct-Dec;51(4):609-13. doi: 10.4103/0019-509X.175359.