PMID- 26843199 OWN - NLM STAT- MEDLINE DCOM- 20180226 LR - 20240130 IS - 1532-6551 (Electronic) IS - 1071-3581 (Print) IS - 1071-3581 (Linking) VI - 24 IP - 2 DP - 2017 Apr TI - In vivo assessment of myocardial viability after acute myocardial infarction: A head-to-head comparison of the perfusable tissue index by PET and delayed contrast-enhanced CMR. PG - 657-667 LID - 10.1007/s12350-015-0329-7 [doi] AB - BACKGROUND: Early recognition of viable myocardium after acute myocardial infarction (AMI) is of clinical relevance, since affected segments have the potential of functional recovery. Delayed contrast-enhanced magnetic resonance imaging (DCE-CMR) has been validated extensively for the detection of viable myocardium. An alternative parameter for detecting viability is the perfusable tissue index (PTI), derived using [(15)O]H(2)O positron emission tomography (PET), which is inversely related to the extent of myocardial scar (non-perfusable tissue). The aim of the present study was to investigate the predictive value of PTI on recovery of LV function as compared to DCE-CMR in patients with AMI, after successful percutaneous coronary intervention (PCI). METHODS: Thirty-eight patients with ST elevation myocardial infarction (STEMI) successfully treated by PCI were prospectively recruited. Subjects were examined 1 week and 3 months (mean follow-up time: 97 +/- 10 days) after AMI using [(15)O]H(2)O PET and DCE-CMR to assess PTI, regional function and scar. Viability was defined as recovery of systolic wall thickening >/=3.0 mm at follow-up by use of CMR. A total of 588 segments were available for serial analysis. RESULTS: At baseline, 180 segments were dysfunctional and exhibited DCE. Seventy-three (41%) of these dysfunctional segments showed full recovery during follow-up (viable), whereas 107 (59%) segments remained dysfunctional (nonviable). Baseline PTI of viable segments was 0.94 +/- 0.09 and was significantly higher compared to nonviable segments (0.80 +/- 0.13, P < .001). The optimal cut-off value for PTI was >/=0.85 with a sensitivity of 85% and specificity of 72%, and an area under the curve (AUC) of 0.82. In comparison, a cut-off value of <32% for the extent of DCE resulted in a sensitivity of 72% and a specificity of 69%, and an AUC of 0.75 (AUC PTI vs DCE P = .14). CONCLUSION: Assessment of myocardial viability shortly after reperfused AMI is feasible using PET. PET-derived PTI yields a good predictive value for the recovery of LV function in PCI-treated STEMI patients, in excellent agreement with DCE-CMR. FAU - Timmer, Stefan A J AU - Timmer SAJ AD - Department of Cardiology, VU University Medical Center, De Boelelaan 1117, 5F013, 1081 HV, Amsterdam, The Netherlands. FAU - Teunissen, Paul F A AU - Teunissen PFA AD - Department of Cardiology, VU University Medical Center, De Boelelaan 1117, 5F013, 1081 HV, Amsterdam, The Netherlands. pf.teunissen@vumc.nl. FAU - Danad, Ibrahim AU - Danad I AD - Department of Cardiology, VU University Medical Center, De Boelelaan 1117, 5F013, 1081 HV, Amsterdam, The Netherlands. AD - Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands. FAU - Robbers, Lourens F H J AU - Robbers LFHJ AD - Department of Cardiology, VU University Medical Center, De Boelelaan 1117, 5F013, 1081 HV, Amsterdam, The Netherlands. FAU - Raijmakers, Pieter G H M AU - Raijmakers PGHM AD - Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands. FAU - Nijveldt, Robin AU - Nijveldt R AD - Department of Cardiology, VU University Medical Center, De Boelelaan 1117, 5F013, 1081 HV, Amsterdam, The Netherlands. FAU - van Rossum, Albert C AU - van Rossum AC AD - Department of Cardiology, VU University Medical Center, De Boelelaan 1117, 5F013, 1081 HV, Amsterdam, The Netherlands. FAU - Lammertsma, Adriaan A AU - Lammertsma AA AD - Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands. FAU - van Royen, Niels AU - van Royen N AD - Department of Cardiology, VU University Medical Center, De Boelelaan 1117, 5F013, 1081 HV, Amsterdam, The Netherlands. FAU - Knaapen, Paul AU - Knaapen P AD - Department of Cardiology, VU University Medical Center, De Boelelaan 1117, 5F013, 1081 HV, Amsterdam, The Netherlands. LA - eng PT - Evaluation Study PT - Journal Article PT - Validation Study DEP - 20160202 PL - United States TA - J Nucl Cardiol JT - Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology JID - 9423534 RN - 0 (Contrast Media) RN - 0 (Oxygen Radioisotopes) RN - 0 (Oxygen-15) RN - 0 (Radiopharmaceuticals) RN - 059QF0KO0R (Water) SB - IM CIN - J Nucl Cardiol. 2017 Apr;24(2):668-671. PMID: 26888373 MH - Contrast Media MH - Early Diagnosis MH - Feasibility Studies MH - Female MH - Humans MH - Magnetic Resonance Imaging, Cine/*methods MH - Male MH - Middle Aged MH - Myocardial Perfusion Imaging/*methods MH - Myocardial Stunning/*diagnostic imaging/*etiology MH - Oxygen Radioisotopes MH - Positron-Emission Tomography/*methods MH - Radiopharmaceuticals MH - Reproducibility of Results MH - ST Elevation Myocardial Infarction/*complications/*diagnostic imaging MH - Sensitivity and Specificity MH - Water PMC - PMC5413541 OTO - NOTNLM OT - Infarction OT - magnetic resonance imaging OT - myocardial OT - myocardial perfusion imaging: PET OT - myocardial viability OT - oxygen-15 water EDAT- 2016/02/05 06:00 MHDA- 2018/02/27 06:00 PMCR- 2016/02/02 CRDT- 2016/02/05 06:00 PHST- 2015/07/08 00:00 [received] PHST- 2015/10/13 00:00 [accepted] PHST- 2016/02/05 06:00 [pubmed] PHST- 2018/02/27 06:00 [medline] PHST- 2016/02/05 06:00 [entrez] PHST- 2016/02/02 00:00 [pmc-release] AID - S1071-3581(23)06476-0 [pii] AID - 329 [pii] AID - 10.1007/s12350-015-0329-7 [doi] PST - ppublish SO - J Nucl Cardiol. 2017 Apr;24(2):657-667. doi: 10.1007/s12350-015-0329-7. Epub 2016 Feb 2.