PMID- 26843318
OWN - NLM
STAT- MEDLINE
DCOM- 20170221
LR  - 20170817
IS  - 1524-4741 (Electronic)
IS  - 1075-122X (Linking)
VI  - 22
IP  - 3
DP  - 2016 May
TI  - Heterologous Liposarcomatous Differentiation in Malignant Phyllodes Tumor is 
      Histologically Similar but Immunohistochemically and Molecularly Distinct from 
      Well-differentiated Liposarcoma of Soft Tissue.
PG  - 282-6
LID - 10.1111/tbj.12567 [doi]
AB  - Malignant phyllodes tumor (PT) infrequently displays heterologous 
      differentiation, and when present is most often liposarcomatous. We identified 
      five cases of malignant PT with regions identical to well-differentiated 
      liposarcoma (WDLS) of soft tissue and evaluated them for MDM2 and CDK4 gene 
      expression and amplification using immunohistochemistry (IHC) and fluorescence in 
      situ hybridization (FISH), respectively. Despite indistinguishable morphology all 
      cases of malignant PT with WDLS-like liposarcomatous differentiation were 
      negative for MDM2 and CDK4 IHC and FISH, supporting different underlying 
      pathogenesis.
CI  - (c) 2016 Wiley Periodicals, Inc.
FAU - Inyang, Alero
AU  - Inyang A
AD  - University of Michigan, Ann Arbor, Michigan.
FAU - Thomas, Dafydd G
AU  - Thomas DG
AD  - University of Michigan, Ann Arbor, Michigan.
FAU - Jorns, Julie
AU  - Jorns J
AD  - University of Michigan, Ann Arbor, Michigan.
LA  - eng
PT  - Journal Article
DEP - 20160204
PL  - United States
TA  - Breast J
JT  - The breast journal
JID - 9505539
RN  - 0 (Biomarkers, Tumor)
RN  - EC 2.3.2.27 (MDM2 protein, human)
RN  - EC 2.3.2.27 (Proto-Oncogene Proteins c-mdm2)
RN  - EC 2.7.11.22 (CDK4 protein, human)
RN  - EC 2.7.11.22 (Cyclin-Dependent Kinase 4)
SB  - IM
MH  - Adult
MH  - Biomarkers, Tumor/genetics/metabolism
MH  - Breast Neoplasms/genetics/metabolism/*pathology
MH  - Cyclin-Dependent Kinase 4/genetics/metabolism
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Liposarcoma/genetics/metabolism/*pathology
MH  - Middle Aged
MH  - Phyllodes Tumor/genetics/metabolism/*pathology
MH  - Proto-Oncogene Proteins c-mdm2/genetics/metabolism
MH  - Soft Tissue Neoplasms/genetics/metabolism/pathology
OTO - NOTNLM
OT  - CDK4
OT  - MDM2
OT  - liposarcoma
OT  - phyllodes tumor
EDAT- 2016/02/05 06:00
MHDA- 2017/02/22 06:00
CRDT- 2016/02/05 06:00
PHST- 2016/02/05 06:00 [entrez]
PHST- 2016/02/05 06:00 [pubmed]
PHST- 2017/02/22 06:00 [medline]
AID - 10.1111/tbj.12567 [doi]
PST - ppublish
SO  - Breast J. 2016 May;22(3):282-6. doi: 10.1111/tbj.12567. Epub 2016 Feb 4.