PMID- 26843618
OWN - NLM
STAT- MEDLINE
DCOM- 20161223
LR  - 20220310
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 7
IP  - 6
DP  - 2016 Feb 9
TI  - Extracorporeal Shock Wave Treatment (ESWT) enhances the in vitro-induced 
      differentiation of human tendon-derived stem/progenitor cells (hTSPCs).
PG  - 6410-23
LID - 10.18632/oncotarget.7064 [doi]
AB  - Extracorporeal shock wave therapy (ESWT) is a non-invasive and innovative 
      technology for the management of specific tendinopathies. In order to elucidate 
      the ESWT-mediated clinical benefits, human Tendon-derived Stem/Progenitor cells 
      (hTSPCs) explanted from 5 healthy semitendinosus (ST) and 5 ruptured Achilles 
      (AT) tendons were established. While hTSPCs from the two groups showed similar 
      proliferation rates and stem cell surface marker profiles, we found that the 
      clonogenic potential was maintained only in cells derived from healthy donors. 
      Interestingly, ESWT significantly accelerated hTSPCs differentiation, suggesting 
      that the clinical benefits of ESWT may be ascribed to increased efficiency of 
      tendon repair after injury.
FAU - Leone, Laura
AU  - Leone L
AD  - Department of Clinical and Molecular Medicine, Faculty of Medicine and 
      Psychology, "Sapienza" University of Rome, Rome, Italy.
FAU - Raffa, Salvatore
AU  - Raffa S
AD  - Department of Clinical and Molecular Medicine, Faculty of Medicine and 
      Psychology, "Sapienza" University of Rome, Rome, Italy.
AD  - Cellular Diagnostics Unit, Sant'Andrea Hospital, Rome, Italy.
FAU - Vetrano, Mario
AU  - Vetrano M
AD  - Department of Orthopedics and Traumatology, Sant'Andrea Hospital, Faculty of 
      Medicine and Psychology, "Sapienza" University of Rome, Rome, Italy.
FAU - Ranieri, Danilo
AU  - Ranieri D
AD  - Department of Clinical and Molecular Medicine, Faculty of Medicine and 
      Psychology, "Sapienza" University of Rome, Rome, Italy.
FAU - Malisan, Florence
AU  - Malisan F
AD  - Department of Biomedicine and Prevention, Laboratory of Signal Transduction, "Tor 
      Vergata" University of Rome, Rome, Italy.
FAU - Scrofani, Cristina
AU  - Scrofani C
AD  - Department of Clinical and Molecular Medicine, Faculty of Medicine and 
      Psychology, "Sapienza" University of Rome, Rome, Italy.
FAU - Vulpiani, Maria Chiara
AU  - Vulpiani MC
AD  - Department of Orthopedics and Traumatology, Sant'Andrea Hospital, Faculty of 
      Medicine and Psychology, "Sapienza" University of Rome, Rome, Italy.
FAU - Ferretti, Andrea
AU  - Ferretti A
AD  - Department of Orthopedics and Traumatology, Sant'Andrea Hospital, Faculty of 
      Medicine and Psychology, "Sapienza" University of Rome, Rome, Italy.
FAU - Torrisi, Maria Rosaria
AU  - Torrisi MR
AD  - Department of Clinical and Molecular Medicine, Faculty of Medicine and 
      Psychology, "Sapienza" University of Rome, Rome, Italy.
AD  - Cellular Diagnostics Unit, Sant'Andrea Hospital, Rome, Italy.
FAU - Visco, Vincenzo
AU  - Visco V
AD  - Department of Clinical and Molecular Medicine, Faculty of Medicine and 
      Psychology, "Sapienza" University of Rome, Rome, Italy.
AD  - Cellular Diagnostics Unit, Sant'Andrea Hospital, Rome, Italy.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
SB  - IM
MH  - Adipogenesis/radiation effects
MH  - Cell Differentiation/*physiology/radiation effects
MH  - Cell Proliferation/*physiology/radiation effects
MH  - Cells, Cultured
MH  - Fluorescent Antibody Technique
MH  - *High-Energy Shock Waves
MH  - Humans
MH  - In Vitro Techniques
MH  - Osteogenesis/radiation effects
MH  - Stem Cells/*cytology/physiology/radiation effects
MH  - Tendon Injuries/*pathology/radiotherapy
MH  - Tendons/*cytology/physiology/radiation effects
PMC - PMC4872723
OTO - NOTNLM
OT  - ESWT
OT  - Pathology Section
OT  - differentiation
OT  - healing
OT  - stem cells
OT  - tendon
COIS- CONFLICTS OF INTEREST The authors declare that there is no conflict of interests.
EDAT- 2016/02/05 06:00
MHDA- 2016/12/24 06:00
PMCR- 2016/02/09
CRDT- 2016/02/05 06:00
PHST- 2015/08/03 00:00 [received]
PHST- 2016/01/13 00:00 [accepted]
PHST- 2016/02/05 06:00 [entrez]
PHST- 2016/02/05 06:00 [pubmed]
PHST- 2016/12/24 06:00 [medline]
PHST- 2016/02/09 00:00 [pmc-release]
AID - 7064 [pii]
AID - 10.18632/oncotarget.7064 [doi]
PST - ppublish
SO  - Oncotarget. 2016 Feb 9;7(6):6410-23. doi: 10.18632/oncotarget.7064.