PMID- 26845016
OWN - NLM
STAT- MEDLINE
DCOM- 20160609
LR  - 20191210
IS  - 1533-7294 (Electronic)
IS  - 0094-3509 (Linking)
VI  - 64
IP  - 12 Suppl
DP  - 2015 Dec
TI  - Hot Topics in Primary Care: Considerations in the Selection of Antihyperglycemic 
      Therapy for Older Patients With Type 2 Diabetes Mellitus: A Focus on Newer 
      Therapies.
PG  - S59-66
LID - jfp_6412x [pii]
AB  - Treatment of type 2 diabetes mellitus (T2DM) in older patients is complicated by 
      a variety of factors and requires an individualized approach. Benefits of 
      intensive glycemic control must be weighed against associated risks. Dipeptidyl 
      peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists, and 
      sodium-glucose cotransporter-2 inhibitors are newer antihyperglycemic agents that 
      effectively lower glycated hemoglobin levels, with a low risk of hypoglycemia, 
      and have a neutral or beneficial effect on weight. The purpose of this review is 
      to discuss challenges in treating older patients with T2DM, and the efficacy and 
      safety of these newer classes based on clinical trials in older populations.
FAU - Freeman, Jeffrey
AU  - Freeman J
AD  - Professor of Internal Medicine, Chairman, Division of Endocrinology and 
      Metabolism, Department of Internal Medicine, Philadelphia College of Osteopathic 
      Medicine, Philadelphia, PA, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Fam Pract
JT  - The Journal of family practice
JID - 7502590
RN  - 0 (Dipeptidyl-Peptidase IV Inhibitors)
RN  - 0 (GLP1R protein, human)
RN  - 0 (Glucagon-Like Peptide-1 Receptor)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (SLC5A2 protein, human)
RN  - 0 (Sodium-Glucose Transporter 2)
RN  - 0 (Sodium-Glucose Transporter 2 Inhibitors)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Diabetes Mellitus, Type 2/*drug therapy
MH  - Dipeptidyl-Peptidase IV Inhibitors/therapeutic use
MH  - Drug Interactions
MH  - Glucagon-Like Peptide-1 Receptor/antagonists & inhibitors
MH  - Humans
MH  - Hypoglycemia/chemically induced/prevention & control
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Polypharmacy
MH  - Sodium-Glucose Transporter 2
MH  - Sodium-Glucose Transporter 2 Inhibitors
EDAT- 2016/02/06 06:00
MHDA- 2016/06/10 06:00
CRDT- 2016/02/05 06:00
PHST- 2016/02/05 06:00 [entrez]
PHST- 2016/02/06 06:00 [pubmed]
PHST- 2016/06/10 06:00 [medline]
AID - jfp_6412x [pii]
PST - ppublish
SO  - J Fam Pract. 2015 Dec;64(12 Suppl):S59-66.