PMID- 26845127
OWN - NLM
STAT- MEDLINE
DCOM- 20171116
LR  - 20190728
IS  - 1873-4286 (Electronic)
IS  - 1381-6128 (Linking)
VI  - 22
IP  - 16
DP  - 2016
TI  - Dendritic Cells in Colorectal Cancer and a Potential for their Use in Therapeutic 
      Approaches.
PG  - 2431-8
AB  - Multiple pathogenic mechanisms contribute to the development of colorectal 
      cancer. This tumor is characterized by high chemoresistance and low 
      immunogenicity due to the effective mechanisms of immunosuppression. Dendritic 
      cells (DCs) play a key role in recognition of tumor antigens and induction of 
      T-cell-primed anticancer response. However, in cancer microenvironment, the 
      function of tumor-infiltrating DCs becomes impaired and switched from the 
      immunostimulation to the immunosuppression. Colorectal cancer cells express 
      anti-inflammatory cytokines such as IL-10 and TGF-beta that could affect DC 
      phenotype and support tumor escape from the immune surveillance. As a result, 
      tumor-associated DCs display numerous defects in antigen-presenting capacity and 
      have an altered pattern of expression of immune costimulatory molecules towards 
      the immunoregulatory phenotype. Indeed, understanding of mechanisms, such as how 
      tumor could impair activity of DCs, would help in the development of new DC-based 
      vaccines against colorectal cancer.
FAU - Chistiakov, Dimitry A
AU  - Chistiakov DA
FAU - Orekhov, Alexander N
AU  - Orekhov AN
FAU - Bobryshev, Yuri V
AU  - Bobryshev YV
AD  - Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia. 
      y.bobryshev@unsw.edu.au.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Pharm Des
JT  - Current pharmaceutical design
JID - 9602487
RN  - 0 (Cancer Vaccines)
SB  - IM
MH  - Animals
MH  - Cancer Vaccines/*immunology
MH  - Colorectal Neoplasms/immunology/*therapy
MH  - Dendritic Cells/*immunology
MH  - Humans
EDAT- 2016/02/05 06:00
MHDA- 2017/11/29 06:00
CRDT- 2016/02/05 06:00
PHST- 2015/11/25 00:00 [received]
PHST- 2016/02/02 00:00 [accepted]
PHST- 2016/02/05 06:00 [entrez]
PHST- 2016/02/05 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
AID - CPD-EPUB-73458 [pii]
AID - 10.2174/1381612822666160203141740 [doi]
PST - ppublish
SO  - Curr Pharm Des. 2016;22(16):2431-8. doi: 10.2174/1381612822666160203141740.