PMID- 26845545
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160205
LR  - 20200930
IS  - 1942-0889 (Print)
IS  - 1942-0889 (Electronic)
IS  - 1942-0889 (Linking)
VI  - 8
IP  - 1
DP  - 2015 Jan-Feb
TI  - Brain size is controlled by the mammalian target of rapamycin (mTOR) in mice.
PG  - e994377
LID - 10.4161/19420889.2014.994377 [doi]
LID - e994377
AB  - The number of neurons in the brain is mostly determined by neural progenitor 
      proliferation and neurogenesis during embryonic development. Increase in 
      postnatal brain size is largely dependent on cellular volume changes. The 
      mammalian target of rapamycin (mTOR) signaling has been associated with cell 
      proliferation and size determination in a variety of cell types. The role of mTOR 
      signaling in neural development has been increasingly pursued due to its 
      association with neurodevelopmental disorders and cancers. Surprisingly, however, 
      there has been lack of in vivo genetic evidence that defines mTOR functions in 
      neural progenitors during progenitor self-renewal and subsequent brain formation. 
      Here, we discuss our recent evidence that mTOR signaling is required for the 
      establishment of normal brain size during development. Mice lacking mTOR show 
      smaller brain and reduced numbers of neural progenitors and neurons. 
      Additionally, mTOR interacts with the Wnt signaling pathway in the control of 
      neural progenitors. Our study establishes the mTOR signal as a key regulator of 
      an evolutionarily conserved cascade that is responsible for vertebrate brain 
      size.
FAU - Kim, Woo-Yang
AU  - Kim WY
AD  - Developmental Neuroscience; Munroe-Meyer Institute; University of Nebraska 
      Medical Center ; Omaha, NE USA.
LA  - eng
PT  - Journal Article
DEP - 20150304
PL  - United States
TA  - Commun Integr Biol
JT  - Communicative & integrative biology
JID - 101478473
PMC - PMC4594332
OTO - NOTNLM
OT  - GSK-3
OT  - brain size
OT  - mTOR
OT  - neural progenitor
OT  - neurogenesis
EDAT- 2016/02/06 06:00
MHDA- 2016/02/06 06:01
PMCR- 2015/03/04
CRDT- 2016/02/05 06:00
PHST- 2014/10/17 00:00 [received]
PHST- 2014/10/20 00:00 [revised]
PHST- 2014/10/24 00:00 [accepted]
PHST- 2016/02/05 06:00 [entrez]
PHST- 2016/02/06 06:00 [pubmed]
PHST- 2016/02/06 06:01 [medline]
PHST- 2015/03/04 00:00 [pmc-release]
AID - 994377 [pii]
AID - 10.4161/19420889.2014.994377 [doi]
PST - epublish
SO  - Commun Integr Biol. 2015 Mar 4;8(1):e994377. doi: 10.4161/19420889.2014.994377. 
      eCollection 2015 Jan-Feb.