PMID- 26847674
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160205
LR  - 20200930
IS  - 2193-8253 (Print)
IS  - 2193-6536 (Electronic)
IS  - 2193-6536 (Linking)
VI  - 4
IP  - 1
DP  - 2015 Jun
TI  - Concurrent Use of Benzodiazepines and Antidepressants and the Risk of Motor 
      Vehicle Accident in Older Drivers: A Nested Case-Control Study.
PG  - 39-51
LID - 10.1007/s40120-015-0026-0 [doi]
AB  - INTRODUCTION: Aging of the population results in an increase in senior drivers. 
      Elderly are frequently treated with benzodiazepines and antidepressants. The 
      objective of this study was to determine whether the concurrent use of 
      benzodiazepines and antidepressants is associated with motor vehicle accidents 
      (MVAs) in the elderly. METHODS: This was a nested case-control study within a 
      cohort of drivers aged 67-84 years between 1990 and 2000, identified from the 
      Societe de l'Assurance Automobile du Quebec and the Regie de l'Assurance Maladie 
      du Quebec databases. First cases of MVAs during follow-up were matched with up to 
      ten controls from the cohort. Odds ratios (ORs) for the association between MVA 
      and the use of benzodiazepines and antidepressants were estimated using 
      conditional logistic regression. RESULTS: The cohort included 373,818 drivers, 
      with 74,503 MVA cases matched with 744,663 controls. The risk of MVA was higher 
      in current users of long-acting benzodiazepines [OR 1.23; 95% confidence interval 
      (CI) 1.16-1.29] than in current users of short-acting benzodiazepines (OR 1.05; 
      95% CI 1.02-1.08). The risk of MVA was increased in current users of selective 
      serotonin reuptake inhibitors (SSRIs; OR 1.13; 95% CI 1.04-1.22), while it was 
      not in current users of tricyclic antidepressants (TCAs; OR 1.04; 95% CI 
      0.96-1.14). The highest ORs of MVA were observed in long-acting benzodiazepines 
      users concurrently using SSRIs (OR 1.37; 95% CI 1.07-1.77, P value for 
      interaction = 0.964) or TCAs (OR 1.54; 95% CI 1.21-1.95, P value for 
      interaction = 0.077). CONCLUSION: Use of long-acting benzodiazepines is 
      associated with an increased risk of MVA in the elderly, particularly in those 
      concurrently using SSRIs or TCAs.
FAU - Fournier, Jean-Pascal
AU  - Fournier JP
AD  - Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, 
      Montreal, Canada.
AD  - Department of Epidemiology, Biostatistics and Occupational Health, McGill 
      University, Montreal, Canada.
FAU - Wilchesky, Machelle
AU  - Wilchesky M
AD  - Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, 
      Montreal, Canada.
AD  - Donald Berman Maimonides Geriatric Center, McGill University, Montreal, QC, 
      Canada.
AD  - Department of Medicine, McGill University, Montreal, QC, Canada.
FAU - Patenaude, Valerie
AU  - Patenaude V
AD  - Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, 
      Montreal, Canada.
FAU - Suissa, Samy
AU  - Suissa S
AD  - Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, 
      Montreal, Canada. samy.suissa@mcgill.ca.
AD  - Department of Epidemiology, Biostatistics and Occupational Health, McGill 
      University, Montreal, Canada. samy.suissa@mcgill.ca.
LA  - eng
PT  - Journal Article
DEP - 20150306
PL  - New Zealand
TA  - Neurol Ther
JT  - Neurology and therapy
JID - 101637818
PMC - PMC4470976
OTO - NOTNLM
OT  - Aged
OT  - Antidepressants
OT  - Automobile driving
OT  - Benzodiazepines
OT  - Drug interactions
EDAT- 2016/02/06 06:00
MHDA- 2016/02/06 06:01
PMCR- 2015/03/06
CRDT- 2016/02/06 06:00
PHST- 2014/12/12 00:00 [received]
PHST- 2016/02/06 06:00 [entrez]
PHST- 2016/02/06 06:00 [pubmed]
PHST- 2016/02/06 06:01 [medline]
PHST- 2015/03/06 00:00 [pmc-release]
AID - 10.1007/s40120-015-0026-0 [pii]
AID - 26 [pii]
AID - 10.1007/s40120-015-0026-0 [doi]
PST - ppublish
SO  - Neurol Ther. 2015 Jun;4(1):39-51. doi: 10.1007/s40120-015-0026-0. Epub 2015 Mar 
      6.