PMID- 2684855
OWN - NLM
STAT- MEDLINE
DCOM- 19900109
LR  - 20221207
IS  - 0194-911X (Print)
IS  - 0194-911X (Linking)
VI  - 14
IP  - 6
DP  - 1989 Dec
TI  - Essential hypertension and histocompatibility antigens. A linkage study.
PG  - 604-9
AB  - It is well established that genetic and environmental factors are involved in the 
      etiology of essential hypertension. The presence of genes predisposing to 
      essential hypertension in the human leukocyte antigen (HLA) complex is 
      controversial because studies of an association between HLA antigens and 
      essential hypertension have failed to yield consistent results. Our aim in the 
      present study was to further investigate this issue through the method of linkage 
      analysis. Analysis of 96 hypertensive siblings distributed in 31 families 
      indicated a significant distortion (p = 0.0009) of the normal segregation pattern 
      of inheritance of HLA haplotypes. Thus, our data indicate that at least one of 
      the genes responsible for genetic predisposition to essential hypertension is 
      located very near or within the HLA complex.
FAU - Gerbase-DeLima, M
AU  - Gerbase-DeLima M
AD  - Escola Paulista de Medicina, Universidade de Sao Paulo, Brazil.
FAU - DeLima, J J
AU  - DeLima JJ
FAU - Persoli, L B
AU  - Persoli LB
FAU - Silva, H B
AU  - Silva HB
FAU - Marcondes, M
AU  - Marcondes M
FAU - Bellotti, G
AU  - Bellotti G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Hypertension
JT  - Hypertension (Dallas, Tex. : 1979)
JID - 7906255
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Black People
MH  - *Family
MH  - *Family Health
MH  - Female
MH  - Gene Frequency
MH  - HLA Antigens/*genetics
MH  - Haplotypes/*genetics
MH  - Humans
MH  - Hypertension/*genetics/immunology
MH  - Male
MH  - Middle Aged
MH  - Pedigree
MH  - *White People
RF  - 37
EDAT- 1989/12/01 00:00
MHDA- 1989/12/01 00:01
CRDT- 1989/12/01 00:00
PHST- 1989/12/01 00:00 [pubmed]
PHST- 1989/12/01 00:01 [medline]
PHST- 1989/12/01 00:00 [entrez]
AID - 10.1161/01.hyp.14.6.604 [doi]
PST - ppublish
SO  - Hypertension. 1989 Dec;14(6):604-9. doi: 10.1161/01.hyp.14.6.604.