PMID- 26848682
OWN - NLM
STAT- MEDLINE
DCOM- 20161018
LR  - 20181113
IS  - 1999-4915 (Electronic)
IS  - 1999-4915 (Linking)
VI  - 8
IP  - 2
DP  - 2016 Feb 3
TI  - Genetic Markers of the Host in Persons Living with HTLV-1, HIV and HCV 
      Infections.
LID - 10.3390/v8020038 [doi]
LID - 38
AB  - Human T-cell leukemia virus type 1 (HTLV-1), hepatitis C virus (HCV) and human 
      immunodeficiency virus type 1 (HIV-1) are prevalent worldwide, and share similar 
      means of transmission. These infections may influence each other in evolution and 
      outcome, including cancer or immunodeficiency. Many studies have reported the 
      influence of genetic markers on the host immune response against different 
      persistent viral infections, such as HTLV-1 infection, pointing to the importance 
      of the individual genetic background on their outcomes. However, despite recent 
      advances on the knowledge of the pathogenesis of HTLV-1 infection, gaps in the 
      understanding of the role of the individual genetic background on the progress to 
      disease clinically manifested still remain. In this scenario, much less is known 
      regarding the influence of genetic factors in the context of dual or triple 
      infections or their influence on the underlying mechanisms that lead to outcomes 
      that differ from those observed in monoinfection. This review describes the main 
      factors involved in the virus-host balance, especially for some particular human 
      leukocyte antigen (HLA) haplotypes, and other important genetic markers in the 
      development of HTLV-1-associated myelopathy/tropical spastic paraparesis 
      (HAM/TSP) and other persistent viruses, such as HIV and HCV.
FAU - Assone, Tatiane
AU  - Assone T
AD  - Laboratory of Dermatology and Immune deficiencies, Department of Dermatology, 
      University of Sao Paulo Medical School, LIM56, Av. Dr. Eneas de Carvalho Aguiar 
      500, 3rd Floor, Building II, Sao Paulo, SP, Brazil. tatianeassone@usp.br.
AD  - Institute of Tropical Medicine of Sao Paulo, Sao Paulo, Brazil. 
      tatianeassone@usp.br.
FAU - Paiva, Arthur
AU  - Paiva A
AD  - Institute of Tropical Medicine of Sao Paulo, Sao Paulo, Brazil. 
      arthurmpaiva@usp.br.
FAU - Fonseca, Luiz Augusto M
AU  - Fonseca LA
AD  - Department of Preventive Medicine, University of Sao Paulo Medical School, Sao 
      Paulo, Brazil. augustom@hcnet.usp.br.
FAU - Casseb, Jorge
AU  - Casseb J
AD  - Laboratory of Dermatology and Immune deficiencies, Department of Dermatology, 
      University of Sao Paulo Medical School, LIM56, Av. Dr. Eneas de Carvalho Aguiar 
      500, 3rd Floor, Building II, Sao Paulo, SP, Brazil. jcasseb@usp.br.
AD  - Institute of Tropical Medicine of Sao Paulo, Sao Paulo, Brazil. jcasseb@usp.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20160203
PL  - Switzerland
TA  - Viruses
JT  - Viruses
JID - 101509722
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Genetic Markers
MH  - HIV Infections/*genetics/virology
MH  - HIV-1/*physiology
MH  - HTLV-I Infections/*genetics/virology
MH  - Human T-lymphotropic virus 1/*physiology
MH  - Humans
PMC - PMC4776193
OTO - NOTNLM
OT  - HCV
OT  - HIV-1
OT  - HTLV-1
OT  - genetic factors
EDAT- 2016/02/06 06:00
MHDA- 2016/10/19 06:00
PMCR- 2016/02/01
CRDT- 2016/02/06 06:00
PHST- 2015/09/24 00:00 [received]
PHST- 2016/01/11 00:00 [revised]
PHST- 2016/01/15 00:00 [accepted]
PHST- 2016/02/06 06:00 [entrez]
PHST- 2016/02/06 06:00 [pubmed]
PHST- 2016/10/19 06:00 [medline]
PHST- 2016/02/01 00:00 [pmc-release]
AID - v8020038 [pii]
AID - viruses-08-00038 [pii]
AID - 10.3390/v8020038 [doi]
PST - epublish
SO  - Viruses. 2016 Feb 3;8(2):38. doi: 10.3390/v8020038.