PMID- 26849031
OWN - NLM
STAT- MEDLINE
DCOM- 20171127
LR  - 20210929
IS  - 1878-0180 (Electronic)
IS  - 1878-0180 (Linking)
VI  - 61
DP  - 2016 Aug
TI  - Bioinspired polydimethylsiloxane-based composites with high shear resistance 
      against wet tissue.
PG  - 87-95
LID - S1751-6161(16)00017-5 [pii]
LID - 10.1016/j.jmbbm.2016.01.014 [doi]
AB  - Patterned microstructures represent a potential approach for improving current 
      wound closure strategies. Microstructures can be fabricated by multiple 
      techniques including replica molding of soft polymer-based materials. However, 
      polymeric microstructures often lack the required shear resistance with tissue 
      needed for wound closure. In this work, scalable microstructures made from 
      composites based on polydimethylsiloxane (PDMS) were explored to enhance the 
      shear resistance with wet tissue. To achieve suitable mechanical properties, PDMS 
      was reinforced by incorporation of polyethylene (PE) particles into the 
      pre-polymer and by coating PE particle reinforced substrates with parylene. The 
      reinforced microstructures showed a 6-fold enhancement, the coated structures 
      even a 13-fold enhancement in Young׳s modulus over pure PDMS. Shear tests of 
      mushroom-shaped microstructures (diameter 450microm, length 1mm) against chicken 
      muscle tissue demonstrate first correlations that will be useful for future 
      design of wound closure or stabilization implants.
CI  - Copyright (c) 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Fischer, Sarah C L
AU  - Fischer SCL
AD  - INM - Leibniz Institute for New Materials, Campus D2 2, 66123 Saarbrucken, 
      Germany; Department of Materials Science and Engineering, Saarland University, 
      Campus D2 2, 66123 Saarbrucken, Germany; Harvard-MIT Division of Health Science 
      and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; 
      Division of Biomedical Engineering, Department of Medicine, Brigham and Women׳s 
      Hospital, Harvard Medical School, Boston, MA 02139, USA.
FAU - Levy, Oren
AU  - Levy O
AD  - Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of 
      Technology, Cambridge, MA 02139, USA; Division of Biomedical Engineering, 
      Department of Medicine, Brigham and Women׳s Hospital, Harvard Medical School, 
      Boston, MA 02139, USA.
FAU - Kroner, Elmar
AU  - Kroner E
AD  - INM - Leibniz Institute for New Materials, Campus D2 2, 66123 Saarbrucken, 
      Germany.
FAU - Hensel, Rene
AU  - Hensel R
AD  - INM - Leibniz Institute for New Materials, Campus D2 2, 66123 Saarbrucken, 
      Germany.
FAU - Karp, Jeffrey M
AU  - Karp JM
AD  - Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of 
      Technology, Cambridge, MA 02139, USA; Division of Biomedical Engineering, 
      Department of Medicine, Brigham and Women׳s Hospital, Harvard Medical School, 
      Boston, MA 02139, USA. Electronic address: jeffkarp.bwh@gmail.com.
FAU - Arzt, Eduard
AU  - Arzt E
AD  - INM - Leibniz Institute for New Materials, Campus D2 2, 66123 Saarbrucken, 
      Germany; Department of Materials Science and Engineering, Saarland University, 
      Campus D2 2, 66123 Saarbrucken, Germany. Electronic address: 
      eduard.arzt@leibniz-inm.de.
LA  - eng
GR  - 340929/ERC_/European Research Council/International
GR  - R01 GM086433/GM/NIGMS NIH HHS/United States
PT  - Journal Article
DEP - 20160125
PL  - Netherlands
TA  - J Mech Behav Biomed Mater
JT  - Journal of the mechanical behavior of biomedical materials
JID - 101322406
RN  - 0 (Dimethylpolysiloxanes)
RN  - 0 (Tissue Adhesives)
SB  - IM
MH  - Animals
MH  - Biomechanical Phenomena
MH  - Chickens
MH  - Dimethylpolysiloxanes/*chemistry
MH  - Materials Testing
MH  - *Shear Strength
MH  - *Stress, Mechanical
MH  - Tissue Adhesives/*chemistry
MH  - *Wound Healing
OTO - NOTNLM
OT  - Bioinspired
OT  - Composite
OT  - Polydimethylsiloxan (PDMS)
OT  - Shear resistance
OT  - Wound closure
EDAT- 2016/02/06 06:00
MHDA- 2017/11/29 06:00
CRDT- 2016/02/06 06:00
PHST- 2015/10/15 00:00 [received]
PHST- 2016/01/18 00:00 [accepted]
PHST- 2016/02/06 06:00 [entrez]
PHST- 2016/02/06 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
AID - S1751-6161(16)00017-5 [pii]
AID - 10.1016/j.jmbbm.2016.01.014 [doi]
PST - ppublish
SO  - J Mech Behav Biomed Mater. 2016 Aug;61:87-95. doi: 10.1016/j.jmbbm.2016.01.014. 
      Epub 2016 Jan 25.