PMID- 26849883
OWN - NLM
STAT- MEDLINE
DCOM- 20170102
LR  - 20170104
IS  - 1477-0962 (Electronic)
IS  - 0961-2033 (Linking)
VI  - 25
IP  - 6
DP  - 2016 May
TI  - Subclinical pulmonary abnormalities in childhood-onset systemic lupus 
      erythematosus patients.
PG  - 645-51
LID - 10.1177/0961203316629554 [doi]
AB  - OBJECTIVE: The aims of this study were to analyze the pulmonary function of 
      childhood-onset systemic lupus erythematosus (cSLE) patients and to identify 
      possible correlations between the high-resolution computed chest tomography 
      (HRCT) score, disease activity, disease cumulative damage, and the participants' 
      quality of life. METHODS: Forty cSLE patients, median age: 14.1 years (range: 
      7.4-17.9), underwent spirometry and plethysmography. Carbon monoxide diffusing 
      capacity (DLCO), HRCT, disease activity, disease cumulative damage, and quality 
      of life were assessed. RESULTS: Pulmonary abnormalities were evident in 19/40 
      (47.5%) cSLE patients according to spirometry/DLCO. Forced expired volume in one 
      second (FEV1%) was the parameter most affected (30%). The HRCT showed some 
      abnormality in 22/30 patients (73%), which were minimal in 43%. Signs of airway 
      affects were found in 50%. Twelve patients were hospitalized due to cSLE-related 
      pulmonary complications before the study began (median discharge: 2.1 years 
      earlier). Total lung capacity (TLC%), vital capacity (VC%), forced vital capacity 
      (FVC%), and FEV1% were significantly lower in the group with hospitalization 
      compared to the group without hospitalization (p = 0.0025, p = 0.0022, 
      p = 0.0032, and p = 0.0004, respectively). Of note, DLCO was positively 
      correlated with disease duration (r = +0.4; p = 0.01). The HRCT-score was 
      negatively correlated with FEV1/VC (r = -0.63; p = 0.0002), FEV1 (r = -0.54; 
      p = 0.018), FEF25%-75% (r = -0.67; p < 0.0001), and HRCT-score was positively 
      correlated with resistance (r = +0.49; p = 0.0056). CONCLUSIONS: Almost half of 
      patients with cSLE had subclinical pulmonary abnormalities, especially airway 
      abnormalities. The cSLE-related pulmonary complications seem to determine 
      long-term functional damage.
CI  - (c) The Author(s) 2016.
FAU - Veiga, C S
AU  - Veiga CS
AD  - Pediatric Pulmonology Unit, Instituto da Crianca do Hospital das Clinicas, 
      University of Sao Paulo Medical School, Sao Paulo, Brazil csveiga1@gmail.com.
FAU - Coutinho, D S
AU  - Coutinho DS
AD  - Pediatric Pulmonology Unit, Instituto da Crianca do Hospital das Clinicas, 
      University of Sao Paulo Medical School, Sao Paulo, Brazil.
FAU - Nakaie, C M A
AU  - Nakaie CM
AD  - Pediatric Pulmonology Unit, Instituto da Crianca do Hospital das Clinicas, 
      University of Sao Paulo Medical School, Sao Paulo, Brazil.
FAU - Campos, L M A
AU  - Campos LM
AD  - Pediatric Rheumatology Unit, Instituto da Crianca do Hospital das Clinicas, 
      University of Sao Paulo Medical School, Sao Paulo, Brazil.
FAU - Suzuki, L
AU  - Suzuki L
AD  - Department of Radiology, Instituto da Crianca do Hospital das Clinicas, 
      University of Sao Paulo Medical School, Sao Paulo, Brazil.
FAU - Cunha, M T
AU  - Cunha MT
AD  - Physical Therapy Service, Instituto da Crianca do Hospital das Clinicas, 
      University of Sao Paulo Medical School, Sao Paulo, Brazil.
FAU - Leone, C
AU  - Leone C
AD  - Department of Maternal and Child Health, College of Public Health, University of 
      Sao Paulo, Brazil.
FAU - Silva, C A
AU  - Silva CA
AD  - Pediatric Rheumatology Unit, Instituto da Crianca do Hospital das Clinicas, 
      University of Sao Paulo Medical School, Sao Paulo, Brazil.
FAU - Rodrigues, J C
AU  - Rodrigues JC
AD  - Pediatric Pulmonology Unit, Instituto da Crianca do Hospital das Clinicas, 
      University of Sao Paulo Medical School, Sao Paulo, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20160204
PL  - England
TA  - Lupus
JT  - Lupus
JID - 9204265
RN  - 7U1EE4V452 (Carbon Monoxide)
SB  - IM
MH  - Adolescent
MH  - Age of Onset
MH  - Carbon Monoxide/metabolism
MH  - Child
MH  - Female
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - Lung Diseases/*etiology/physiopathology
MH  - Lupus Erythematosus, Systemic/*complications/physiopathology
MH  - Male
MH  - Plethysmography
MH  - *Quality of Life
MH  - Respiratory Function Tests
MH  - Spirometry
MH  - Tomography, X-Ray Computed/methods
MH  - Vital Capacity
OTO - NOTNLM
OT  - Systemic lupus erythematosus
OT  - anti-DNA antibodies
OT  - vasculitis
EDAT- 2016/02/07 06:00
MHDA- 2017/01/04 06:00
CRDT- 2016/02/07 06:00
PHST- 2015/07/26 00:00 [received]
PHST- 2016/01/07 00:00 [accepted]
PHST- 2016/02/07 06:00 [entrez]
PHST- 2016/02/07 06:00 [pubmed]
PHST- 2017/01/04 06:00 [medline]
AID - 0961203316629554 [pii]
AID - 10.1177/0961203316629554 [doi]
PST - ppublish
SO  - Lupus. 2016 May;25(6):645-51. doi: 10.1177/0961203316629554. Epub 2016 Feb 4.