PMID- 26849906
OWN - NLM
STAT- MEDLINE
DCOM- 20170117
LR  - 20211203
IS  - 1096-3634 (Electronic)
IS  - 1084-9521 (Print)
IS  - 1084-9521 (Linking)
VI  - 52
DP  - 2016 Apr
TI  - The role of mTOR signalling in neurogenesis, insights from tuberous sclerosis 
      complex.
PG  - 12-20
LID - S1084-9521(16)30038-6 [pii]
LID - 10.1016/j.semcdb.2016.01.040 [doi]
AB  - Understanding the development and function of the nervous system is one of the 
      foremost aims of current biomedical research. The nervous system is generated 
      during a relatively short period of intense neurogenesis that is orchestrated by 
      a number of key molecular signalling pathways. Even subtle defects in the 
      activity of these molecules can have serious repercussions resulting in 
      neurological, neurodevelopmental and neurocognitive problems including epilepsy, 
      intellectual disability and autism. Tuberous sclerosis complex (TSC) is a 
      monogenic disease characterised by these problems and by the formation of benign 
      tumours in multiple organs, including the brain. TSC is caused by mutations in 
      the TSC1 or TSC2 gene leading to activation of the mechanistic target of 
      rapamycin (mTOR) signalling pathway. A desire to understand the neurological 
      manifestations of TSC has stimulated research into the role of the mTOR pathway 
      in neurogenesis. In this review we describe TSC neurobiology and how the use of 
      animal model systems has provided insights into the roles of mTOR signalling in 
      neuronal differentiation and migration. Recent progress in this field has 
      identified novel mTOR pathway components regulating neuronal differentiation. The 
      roles of mTOR signalling and aberrant neurogenesis in epilepsy are also 
      discussed. Continuing efforts to understand mTOR neurobiology will help to 
      identify new therapeutic targets for TSC and other neurological diseases.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Tee, Andrew R
AU  - Tee AR
AD  - Institute of Cancer & Genetics, Cardiff University School of Medicine, Institute 
      of Medical Genetics Building, Heath Park, Cardiff CF14 4XN UK.
FAU - Sampson, Julian R
AU  - Sampson JR
AD  - Institute of Cancer & Genetics, Cardiff University School of Medicine, Institute 
      of Medical Genetics Building, Heath Park, Cardiff CF14 4XN UK.
FAU - Pal, Deb K
AU  - Pal DK
AD  - Department of Basic & Clinical Neurosciences, Institute of Psychiatry, Psychology 
      & Neuroscience, King's College, London SE5 8RX UK.
FAU - Bateman, Joseph M
AU  - Bateman JM
AD  - Wolfson Centre for Age-Related Diseases, King's College London, Guy's Campus, 
      London SE1 1UL UK. Electronic address: joseph_matthew.bateman@kcl.ac.uk.
LA  - eng
GR  - 200668/Wellcome Trust/United Kingdom
GR  - 201503MOP-342469/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20160202
PL  - England
TA  - Semin Cell Dev Biol
JT  - Seminars in cell & developmental biology
JID - 9607332
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Humans
MH  - *Neurogenesis
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases/*metabolism
MH  - Tuberous Sclerosis/enzymology/genetics/*metabolism/*pathology
PMC - PMC6379054
MID - EMS81729
OTO - NOTNLM
OT  - Epilepsy
OT  - Neural stem cell
OT  - Neuronal differentiation
OT  - Neuronal migration
OT  - TSC
OT  - mTOR
EDAT- 2016/02/07 06:00
MHDA- 2017/01/18 06:00
PMCR- 2019/02/18
CRDT- 2016/02/07 06:00
PHST- 2015/10/26 00:00 [received]
PHST- 2016/01/05 00:00 [revised]
PHST- 2016/01/25 00:00 [accepted]
PHST- 2016/02/07 06:00 [entrez]
PHST- 2016/02/07 06:00 [pubmed]
PHST- 2017/01/18 06:00 [medline]
PHST- 2019/02/18 00:00 [pmc-release]
AID - S1084-9521(16)30038-6 [pii]
AID - 10.1016/j.semcdb.2016.01.040 [doi]
PST - ppublish
SO  - Semin Cell Dev Biol. 2016 Apr;52:12-20. doi: 10.1016/j.semcdb.2016.01.040. Epub 
      2016 Feb 2.