PMID- 26850117
OWN - NLM
STAT- MEDLINE
DCOM- 20170510
LR  - 20220331
IS  - 1473-0766 (Electronic)
IS  - 0951-3590 (Linking)
VI  - 32
IP  - 7
DP  - 2016 Jul
TI  - The association between a novel polymorphism (rs1062577) in ESR1 and breast 
      cancer susceptibility in the Han Chinese women.
PG  - 553-6
LID - 10.3109/09513590.2016.1138462 [doi]
AB  - OBJECTIVE: The aim of the present study was to analyze the genetic association 
      between the three estrogen receptor 1 (ESR1) single nucleotide polymorphisms 
      (SNPs; rs1062577, rs2881766, and rs9479118) and breast cancer risk in Han Chinese 
      women. METHODS/MATERIALS: To investigate the possible association of genetic 
      polymorphisms of any of the three ESR1 SNPs in breast cancer patients (n = 198) 
      and healthy controls (n = 218) collected from the college hospital, peripheral 
      blood mononuclear cells samples were analyzed by high-resolution melt-polymerase 
      chain reaction. Odds ratios and 95% confidence intervals were used to evaluate 
      the association between the ESR1 SNPs and breast cancer. RESULTS: Patients 
      genotyped AA for ESR1 rs1062577 showed increased breast cancer risk (p = 0.005). 
      In the menarche at </= 13-year-old group, there were significant differences in 
      alleles A versus T at rs1062577 and alleles G versus T at rs2881766 between the 
      breast cancer group and the control group. In the > 13-year-old group, the AA 
      genotype at rs1062577, the GG genotype at rs2881766, and the CC genotype at 
      rs9479118 increased breast cancer susceptibility. CONCLUSIONS: These results 
      showed that the ESR1 rs1062577 polymorphism increased breast cancer risk in Han 
      Chinese women, which might be used as a new SNP marker.
FAU - Chen, Li
AU  - Chen L
AD  - a Department of Laboratory Medicine , The First Affiliated Hospital of China 
      Medical University , Shenyang , Liaoning Province , China.
FAU - Kang, Hui
AU  - Kang H
AD  - a Department of Laboratory Medicine , The First Affiliated Hospital of China 
      Medical University , Shenyang , Liaoning Province , China.
FAU - Jin, Guo-Jiang
AU  - Jin GJ
AD  - a Department of Laboratory Medicine , The First Affiliated Hospital of China 
      Medical University , Shenyang , Liaoning Province , China.
FAU - Chen, Xin
AU  - Chen X
AD  - a Department of Laboratory Medicine , The First Affiliated Hospital of China 
      Medical University , Shenyang , Liaoning Province , China.
FAU - Zhang, Qing-Yang
AU  - Zhang QY
AD  - a Department of Laboratory Medicine , The First Affiliated Hospital of China 
      Medical University , Shenyang , Liaoning Province , China.
FAU - Lao, Wen-Ting
AU  - Lao WT
AD  - a Department of Laboratory Medicine , The First Affiliated Hospital of China 
      Medical University , Shenyang , Liaoning Province , China.
FAU - Li, Rui
AU  - Li R
AD  - a Department of Laboratory Medicine , The First Affiliated Hospital of China 
      Medical University , Shenyang , Liaoning Province , China.
LA  - eng
PT  - Journal Article
DEP - 20160205
PL  - England
TA  - Gynecol Endocrinol
JT  - Gynecological endocrinology : the official journal of the International Society 
      of Gynecological Endocrinology
JID - 8807913
RN  - 0 (ESR1 protein, human)
RN  - 0 (Estrogen Receptor alpha)
SB  - IM
MH  - Adult
MH  - Breast Neoplasms/*genetics
MH  - China
MH  - Estrogen Receptor alpha/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Menarche/*genetics
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - Breast cancer
OT  - Chinese women
OT  - estrogen receptor 1
OT  - rs1062577
OT  - single nucleotide polymorphisms
EDAT- 2016/02/07 06:00
MHDA- 2017/05/11 06:00
CRDT- 2016/02/07 06:00
PHST- 2016/02/07 06:00 [entrez]
PHST- 2016/02/07 06:00 [pubmed]
PHST- 2017/05/11 06:00 [medline]
AID - 10.3109/09513590.2016.1138462 [doi]
PST - ppublish
SO  - Gynecol Endocrinol. 2016 Jul;32(7):553-6. doi: 10.3109/09513590.2016.1138462. 
      Epub 2016 Feb 5.