PMID- 26850876
OWN - NLM
STAT- MEDLINE
DCOM- 20161219
LR  - 20161230
IS  - 1531-5053 (Electronic)
IS  - 0278-2391 (Linking)
VI  - 74
IP  - 6
DP  - 2016 Jun
TI  - Effect of p38 Mitogen Activated Protein Kinase Inhibitor on Temporomandibular 
      Joint Synovitis Induced by Occlusal Alteration.
PG  - 1131-9
LID - S0278-2391(16)00012-4 [pii]
LID - 10.1016/j.joms.2015.12.020 [doi]
AB  - PURPOSE: To investigate the alteration in rat temporomandibular joint (TMJ) 
      synovial membrane induced by increased occlusal vertical dimension (iOVD) and to 
      determine whether the p38 mitogen activated protein kinase (MAPK) signaling 
      cascade is involved. MATERIALS AND METHODS: Thirty-six rats were randomly divided 
      into 3 groups: control + normal saline (NS; controls), iOVD + NS, and iOVD + 
      SB203580 (a potent p38 MAPK inhibitor). Morphologic changes of synovial tissues 
      were observed and scored. Activation levels of p38 MAPK and activating 
      transcription factor-2 (ATF2) were detected by immunohistochemistry. Expression 
      levels of interleukin-1beta (IL-1beta) and matrix metalloproteinase-3 (MMP-3) were 
      measured by quantitative real-time polymerase chain reaction and 
      immunohistochemistry. RESULTS: Obvious synovitis was found in the iOVD group. P38 
      and ATF2 were activated, and mRNA and protein expression levels of IL-1beta and 
      MMP-3 were upregulated after iOVD. However, decreased synovial tissue 
      inflammation and lower mRNA and protein levels of IL-1beta and MMP-3 were observed 
      in the iOVD + SB203580 group. CONCLUSION: iOVD can induce temporomandibular joint 
      synovitis, and the p38 MAPK signaling cascade might participate in and aggravate 
      the process of articular inflammation.
CI  - Copyright (c) 2016 The American Association of Oral and Maxillofacial Surgeons. 
      Published by Elsevier Inc. All rights reserved.
FAU - Jiang, Linhong
AU  - Jiang L
AD  - Dental student, Stomatological Hospital of Shandong University and the Shandong 
      Province Key Laboratory of Oral Tissue Regeneration, Jinan City, Shandong 
      Province, China.
FAU - Lin, Xuefen
AU  - Lin X
AD  - Resident, Stomatological Hospital of Shandong University and the Shandong 
      Province Key Laboratory of Oral Tissue Regeneration, Jinan City, Shandong 
      Province, China.
FAU - Ji, Ping
AU  - Ji P
AD  - Professor, Stomatological Hospital of Shandong University and the Shandong 
      Province Key Laboratory of Oral Tissue Regeneration, Jinan City, Shandong 
      Province, China. Electronic address: jiping@mail.sdu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20160107
PL  - United States
TA  - J Oral Maxillofac Surg
JT  - Journal of oral and maxillofacial surgery : official journal of the American 
      Association of Oral and Maxillofacial Surgeons
JID - 8206428
RN  - 0 (Imidazoles)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Pyridines)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - OU13V1EYWQ (SB 203580)
SB  - IM
MH  - Animals
MH  - Imidazoles/pharmacology
MH  - Interleukin-1beta/metabolism
MH  - Male
MH  - Malocclusion/*complications/physiopathology
MH  - Matrix Metalloproteinase 3/metabolism
MH  - Pyridines/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Real-Time Polymerase Chain Reaction
MH  - Synovitis/*etiology/pathology/physiopathology
MH  - Temporomandibular Joint Disorders/*etiology/pathology/physiopathology
MH  - p38 Mitogen-Activated Protein Kinases/*antagonists & inhibitors
EDAT- 2016/02/07 06:00
MHDA- 2016/12/20 06:00
CRDT- 2016/02/07 06:00
PHST- 2015/08/03 00:00 [received]
PHST- 2015/12/28 00:00 [revised]
PHST- 2015/12/30 00:00 [accepted]
PHST- 2016/02/07 06:00 [entrez]
PHST- 2016/02/07 06:00 [pubmed]
PHST- 2016/12/20 06:00 [medline]
AID - S0278-2391(16)00012-4 [pii]
AID - 10.1016/j.joms.2015.12.020 [doi]
PST - ppublish
SO  - J Oral Maxillofac Surg. 2016 Jun;74(6):1131-9. doi: 10.1016/j.joms.2015.12.020. 
      Epub 2016 Jan 7.