PMID- 26851156 OWN - NLM STAT- MEDLINE DCOM- 20170214 LR - 20220408 IS - 1873-2933 (Electronic) IS - 0009-9120 (Linking) VI - 49 IP - 9 DP - 2016 Jun TI - Relationship of N-Terminal fragment of Pro-B-Type Natriuretic Peptide and copeptin with erythrocytes-related parameters: A population-based study. PG - 651-656 LID - S0009-9120(16)00048-5 [pii] LID - 10.1016/j.clinbiochem.2016.01.021 [doi] AB - BACKGROUND: Plasma levels of natriuretic peptides (NP) have been inversely related to hemoglobin (Hb) concentration in prior studies. However, the mechanism underlying this association remains unclear. We aimed to obtain further insights into potential mechanisms for this correlation in a cohort of healthy adults. METHODS: A population-based study was performed among 2113 healthy adults aged 25-41years. Relationships of N-Terminal fragment of Pro-B-Type Natriuretic Peptide (NT-proBNP) or copeptin with volume-dependent (Hb, hematocrit (Hct), erythrocyte count (EC), mean corpuscular Hb concentration (MCHC)) and volume-independent (mean corpuscular volume (MCV), mean corpuscular Hb (MCH)) erythrocyte-related parameters were assessed using sex-specific multivariable linear regression analyses. RESULTS: The median age was 36.7years. Median NT-proBNP (ng/L) levels were 49.5 and 20 among women and men, respectively (p<0.0001). Mean (standard deviation) Hb (g/L) levels were 130.1(9.1) and 149.7(8.6) among women and men, respectively (p<0.0001). Among men, multivariable adjusted beta-coefficients (95% confidence interval) for NT-proBNP were -1.68 (-2.36; -1.01), p<0.0001 for Hb; -0.38 (-0.57; -0.20), p<0.0001 for Hct; -0.06 (-0.09; -0.04), p<0.0001 for EC; -0.78 (-1.50; -0.07), p=0.03 for MCHC; 0.26 (-0.04; 0.56), p=0.09 for MCV; and 0.03 (-0.08; 0.14), p=0.61 for MCH. For copeptin, these relationships were 1.36 (0.39; 2.32), p=0.006; 0.41 (0.15; 0.68), p=0.002; 0.06 (0.02; 0.09), p=0.002; -0.17 (-1.19; 0.86), p=0.75; -0.12 (-0.55; 0.31), p=0.58 and -0.05 (-0.21; 0.10), p=0.52. Similar results were observed among women. CONCLUSIONS: We found significant relationships of NT-proBNP and copeptin with volume-dependent but not volume-independent erythrocyte-related parameters, suggesting that hemodilution may at least in part explain these associations. CI - Copyright (c) 2016 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. FAU - Ruperti Repilado, Francisco Javier AU - Ruperti Repilado FJ AD - Internal Medicine Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Cardiovascular Research Institute Basel, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland. FAU - Aeschbacher, Stefanie AU - Aeschbacher S AD - Internal Medicine Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Cardiovascular Research Institute Basel, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland. FAU - Bossard, Matthias AU - Bossard M AD - Cardiovascular Research Institute Basel, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Cardiology Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland. FAU - Schoen, Tobias AU - Schoen T AD - Internal Medicine Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Cardiovascular Research Institute Basel, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland. FAU - Gugganig, Rebecca AU - Gugganig R AD - Cardiovascular Research Institute Basel, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland. FAU - van der Stouwe, Jan Gerrit AU - van der Stouwe JG AD - Internal Medicine Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Cardiovascular Research Institute Basel, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland. FAU - Krisai, Philipp AU - Krisai P AD - Internal Medicine Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Cardiovascular Research Institute Basel, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland. FAU - Kofler, Thomas AU - Kofler T AD - Internal Medicine Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Cardiovascular Research Institute Basel, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland. FAU - Buser, Andreas AU - Buser A AD - Hematology Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland. FAU - Risch, Martin AU - Risch M AD - Labormedizinisches Zentrum Dr. Risch, Schaan, FL, Liechtenstein; Division of Laboratory Medicine, Kantonsspital Graubunden, Chur, Switzerland. FAU - Risch, Lorenz AU - Risch L AD - Labormedizinisches Zentrum Dr. Risch, Schaan, FL, Liechtenstein; Division of Clinical Biochemistry, Medical University Innsbruck, Innsbruck, Austria; UFL Private University, Furstentum, Liechtenstein. FAU - Mueller, Christian AU - Mueller C AD - Internal Medicine Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Cardiovascular Research Institute Basel, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Cardiology Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland. FAU - Conen, David AU - Conen D AD - Internal Medicine Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Cardiovascular Research Institute Basel, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; Cardiology Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland. Electronic address: david.conen@usb.ch. LA - eng PT - Journal Article DEP - 20160202 PL - United States TA - Clin Biochem JT - Clinical biochemistry JID - 0133660 RN - 0 (Biomarkers) RN - 0 (Glycopeptides) RN - 0 (Peptide Fragments) RN - 0 (copeptins) RN - 0 (pro-brain natriuretic peptide (1-76)) RN - 114471-18-0 (Natriuretic Peptide, Brain) SB - IM MH - Adult MH - Biomarkers/*blood MH - Erythrocyte Indices MH - Erythrocytes/*pathology MH - Female MH - Follow-Up Studies MH - Glycopeptides/*blood MH - Heart Failure/blood/*epidemiology/pathology MH - Humans MH - Male MH - Natriuretic Peptide, Brain/*blood MH - Peptide Fragments/*blood MH - Prognosis MH - Prospective Studies MH - Switzerland/epidemiology OTO - NOTNLM OT - Copeptin OT - Epidemiology OT - Hemodilution OT - Hemoglobin OT - Natriuretic peptides OT - Population-based EDAT- 2016/02/07 06:00 MHDA- 2017/02/15 06:00 CRDT- 2016/02/07 06:00 PHST- 2015/11/13 00:00 [received] PHST- 2016/01/28 00:00 [revised] PHST- 2016/01/29 00:00 [accepted] PHST- 2016/02/07 06:00 [entrez] PHST- 2016/02/07 06:00 [pubmed] PHST- 2017/02/15 06:00 [medline] AID - S0009-9120(16)00048-5 [pii] AID - 10.1016/j.clinbiochem.2016.01.021 [doi] PST - ppublish SO - Clin Biochem. 2016 Jun;49(9):651-656. doi: 10.1016/j.clinbiochem.2016.01.021. Epub 2016 Feb 2.