PMID- 26852388
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20220408
IS  - 1872-7603 (Electronic)
IS  - 0165-0378 (Linking)
VI  - 114
DP  - 2016 Apr
TI  - Decidual soluble factors, through modulation of dendritic cells functions, 
      determine the immune response patterns at the feto-maternal interface.
PG  - 10-7
LID - S0165-0378(16)30003-1 [pii]
LID - 10.1016/j.jri.2016.01.001 [doi]
AB  - Dendritic cells (DCs) can acquire immunogenic or tolerogenic properties depending 
      on intrinsic and tissue environmental factors. We aimed to determine the 
      immunomodulatory effects of decidual soluble factors from abortion- and 
      non-abortion-prone mice on DC functions. The decidual cell supernatants (DS) were 
      obtained from abortion-prone and non-abortion-prone mice. Splenic DCs were 
      treated with DS and conalbumin (as an antigen) and injected into the palms of the 
      mice. After five days, regional lymph node cells were collected and cultured in 
      the presence and absence of conalbumin. The proliferation of lymphocyte cells, 
      the frequency of regulatory T cells (Tregs), and the production of IL-4 and IFN-gamma 
      were measured by [(3)H]thymidine incorporation, flow cytometry, and ELISA 
      respectively. Our results indicated that DS from both abortion- and 
      non-abortion-prone mice decreased the ability of DCs to induce lymphocyte 
      proliferation and IFN-gamma production, while enhanced their capacity to induce Tregs 
      compared with non-treated DCs. Another important finding was that the 
      immunosuppressive effects of DS from abortion-prone mice on DCs for inducing 
      proliferative responses, developing Tregs, and producing IFN-gamma by primed 
      lymphocytes was less than DS from non-abortion-prone mice. We also found that 
      only DS from non-abortion-prone mice could enhance the capacity of DCs to induce 
      IL-4 production by primed lymphocytes. It can be concluded that decidua-secreted 
      factors, by altering DC functions, can determine the pattern of immune responses 
      at the fetomaternal interface and, subsequently, pregnancy outcome.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Ahmadabad, Hasan Namdar
AU  - Ahmadabad HN
AD  - Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares 
      University, Tehran, Iran; Department of Pathobiology and Medical Laboratory 
      Science, School of Medicine, North Khorasan University of Medical Sciences, 
      Bojnurd, Iran.
FAU - Salehnia, Mojdeh
AU  - Salehnia M
AD  - Department of Anatomy, Faculty of Medical Sciences, Tehran, Iran.
FAU - Saito, Shigeru
AU  - Saito S
AD  - Department of Obstetrics and Gynecology, Graduate School of Medicine and 
      Pharmaceutical Science for Research, University of Toyama,Toyama, Japan.
FAU - Moazzeni, Seyed Mohammad
AU  - Moazzeni SM
AD  - Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares 
      University, Tehran, Iran. Electronic address: moazzeni@modares.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160107
PL  - Ireland
TA  - J Reprod Immunol
JT  - Journal of reproductive immunology
JID - 8001906
RN  - 0 (IFNG protein, mouse)
RN  - 207137-56-2 (Interleukin-4)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Decidua/cytology/*immunology
MH  - Dendritic Cells/cytology/*immunology
MH  - Female
MH  - Interferon-gamma/*immunology
MH  - Interleukin-4/*immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Placenta/cytology/*immunology
MH  - Pregnancy
MH  - T-Lymphocytes, Regulatory/cytology/*immunology
OTO - NOTNLM
OT  - Abortion
OT  - Decidua
OT  - Dendritic cell
OT  - Lymphocyte
EDAT- 2016/02/08 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/02/08 06:00
PHST- 2015/11/13 00:00 [received]
PHST- 2016/01/04 00:00 [accepted]
PHST- 2016/02/08 06:00 [entrez]
PHST- 2016/02/08 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S0165-0378(16)30003-1 [pii]
AID - 10.1016/j.jri.2016.01.001 [doi]
PST - ppublish
SO  - J Reprod Immunol. 2016 Apr;114:10-7. doi: 10.1016/j.jri.2016.01.001. Epub 2016 
      Jan 7.